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Analgesic Efficacy of Quick-Release versus Standard Lornoxicam for Pain after Third Molar Surgery

A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Trial

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Abstract

Objective: The aim of this study was to evaluate the analgesic efficacy and time to onset of effect of the lornoxicam quick-release (LNX-QR) tablet compared with the standard-release tablet (LNX-ST).

Methods: In this randomized, double-blind, single-dose trial, 200 patients with moderate pain after surgical removal of an impacted third molar were randomized to treatment with an LNX-QR 8 mg tablet (80 patients), an LNX-ST 8 mg tablet (80 patients) or placebo (40 patients). Pain intensity (PI) and pain relief (PAR) were assessed (numerical and verbal rating scales) for 6 hours, and time to onset of PAR was recorded. The cumulated sum of PI differences (SPID) and PAR (TOTPAR) were calculated. Tolerability was evaluated by occurrence of adverse events.

Results: Kaplan-Meier analysis of time to onset of analgesic efficacy demonstrated a significantly faster onset with LNX-QR than placebo or LNX-ST (p < 0.0001). Median time of onset was 32 minutes (range 29–37) for LNX-QR and 46 minutes (range 37–59) for LNX-ST. The analgesic efficacy of LNX-QR and LNX-ST were superior to that of placebo, whereas paired comparisons of TOTPAR and SPID showed LNX-QR to be superior to LNX-ST (p < 0.05).

Conclusion: LNX-QR provided a faster onset and superior analgesic effect against pain following third molar surgery than LNX-ST.

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Acknowledgements

The conduct of this study and the preparation of the manuscript were supported by an unrestricted grant from Nycomed. The authors have no conflicts of interest that are directly relevant to the content of this study.

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  1. Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark

    Philip L. Móller & Sven E. Nórholt

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  1. Philip L. Móller
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  2. Sven E. Nórholt
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Móller, P.L., Nórholt, S.E. Analgesic Efficacy of Quick-Release versus Standard Lornoxicam for Pain after Third Molar Surgery. Clin. Drug Investig. 28, 757–766 (2008). https://doi.org/10.2165/0044011-200828120-00003

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