Skip to main content
Log in

Topiramate Therapy for Symptomatic Trigeminal Neuralgia

  • Case Report
  • Published:
Clinical Drug Investigation Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Crayton H, Heyman RA, Rosmann HS. A multimodal approach to managing the symptoms of multiple sclerosis. Neurology 2004; 63: S12–8

    Article  PubMed  Google Scholar 

  2. Tomson T, Tybring G, Bertilsson L, et al. Carbamazepine therapy in trigeminal neuralgia: clinical effects in relation to plasma concentration. Arch Neurol 1980; 37: 699–703

    Article  PubMed  CAS  Google Scholar 

  3. Tomson T, Bertilsson L. Potent therapeutic effect of carbamazepine-10,11-epoxide in trigeminal neuralgia. Arch Neurol 1984; 41: 588–601

    Google Scholar 

  4. Cheshire WP. Trigeminal neuralgia: a guide to drug choice. CNS Drugs 1997; 7: 98–110

    Article  CAS  Google Scholar 

  5. Sindrup SH, Jensen TS. Pharmacotherapy of trigeminal neuralgia. Clin J Pain 2002; 18: 22–7

    Article  PubMed  Google Scholar 

  6. Peiris JB, Perera GLS, Devendra SV, et al. Sodium valproate in trigeminal neuralgia [letter]. Med J Aust 1980; 2: 278

    PubMed  CAS  Google Scholar 

  7. Desai N, Shah K, Gandhi I. Baclofen sodium valproate combination in carbamazepine resistant trigeminal neuralgia: a double blind clinical trial. Cephalalgia 1991; 11Suppl. 11: 321–2

    Google Scholar 

  8. Zakrzewska JM, Chaudhry Z, Nurmikko TJ, et al. Lamotrigine (Lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial. Pain 1997; 73: 223–30

    Article  PubMed  CAS  Google Scholar 

  9. Khan OA. Gabapentin relieves trigeminal neuralgia in multiple sclerosis patients. Neurology 1998; 51: 611–4

    Article  PubMed  CAS  Google Scholar 

  10. Zvartau-Hind M, Din MU, Gilani A, et al. Topiramate relieves refractory trigeminal neuralgia in MS patients. Neurology 2000; 55: 1587–8

    Article  PubMed  CAS  Google Scholar 

  11. Spina E, Perugi G. Antiepileptic drugs: indications other than epilepsy. Epileptic Disord 2004; 6: 57–65

    PubMed  Google Scholar 

  12. Jensen MP, Turner JA, Romano JM. What is the maximum number of levels needed in pain intensity measurement? Pain 1994; 58: 387–92

    Article  PubMed  CAS  Google Scholar 

  13. Berthier F, Potel G, Leconte P, et al. Comparative study of methods of measuring acute pain intensity in an ED. Am J Emerg Med 1998; 16: 132–6

    Article  PubMed  CAS  Google Scholar 

  14. Perucca E. An introduction to antiepileptic drugs. Epilepsia 2005; 46: 31–7

    Article  PubMed  CAS  Google Scholar 

  15. Gilron I, Booher SL, Rowan JS, et al. Topiramate in trigeminal neuralgia: a randomized, placebo-controlled multiple crossover pilot study. Clin Neuropharmacol 2001; 24(2): 109–12

    Article  PubMed  CAS  Google Scholar 

  16. Burchiel KJ. Abnormal impulse generation in focally demyelinated trigeminal roots. J Neurosurg 1980; 53: 674–83

    Article  PubMed  CAS  Google Scholar 

  17. Sakurai M, Kanazawa I. Positive symptoms in multiple sclerosis: their treatment with sodium channel blockers, lidocaine and mexiletine. J Neurol Sci 1999; 15: 162–8

    Article  Google Scholar 

  18. Solaro C, Lunardi GL, Capello E, et al. An open-label trial of gabapentin treatment of paroxysmal symptoms in multiple sclerosis patients. Neurology 1998; 51: 609–11

    Article  PubMed  CAS  Google Scholar 

  19. Russo E, Constanti A, Ferreri G, et al. Nifedipine affects the anticonvulsant activity of topiramate in various animal models of epilepsy. Neuropharmacology 2004; 46: 865–78

    Article  PubMed  CAS  Google Scholar 

  20. Tidwell A, Swims M. Review of the newer antiepileptic drugs. Am J Manag Care 2003; 9: 253–76

    PubMed  Google Scholar 

  21. Nieto-Barrera M. Characteristics and indications of topiramate. Rev Neurol 2002; 35Suppl. 1: S88–95

    PubMed  Google Scholar 

  22. Bialer M, Doose DR, Murthy B, et al. Pharmacokinetic interactions of topiramate. Clin Pharmacokinet 2004; 43: 763–80

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

The authors acknowledge financial support for this study from the Ministero della Salute (Programma di Ricerca Finalizzata anno 2002; Farmaci e fitoterapici, impatto sulla salute, vigilanza e sviluppo di un modello organizzativo interregionale. Programmi Speciali ex Art. 12, D.Lgs 502/99). The authors have no conflicts of interest that are directly relevant to the contents of this case report.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to L. Gallelli.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Siniscalchi, A., Gallelli, L., Scornaienghi, D. et al. Topiramate Therapy for Symptomatic Trigeminal Neuralgia. Clin. Drug Investig. 26, 113–115 (2006). https://doi.org/10.2165/00044011-200626020-00006

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00044011-200626020-00006

Keywords

Navigation