Abstract
Several meta-analyses examining the effects of exercise on depression have been criticized for including studies of poor methodological integrity. More recent meta-analyses addressed the most common criticism by including only randomized control trials; however, these analyses suffer from incomplete literature searches and lack of moderating variable analyses. Using a more extensive search procedure, the current meta-analysis examines the effects of exercise on depressive symptoms in 58 randomized trials (n = 2982). An overall effect size of −0.80 indicates participants in the exercise treatment had significantly lower depression scores than those receiving the control treatment. This 3/4 SD advantage represents level 1, Grade A evidence for the effects of exercise upon depression. Analysis of moderating variables examined the influence of population characteristics, exercise characteristics and methodological characteristics. Examination of clinical significance in 16 trials with clinically depressed patients found 9 of 16 exercise treatment groups were classified as ‘recovered’ at post-treatment, with another three groups classified as ‘improved’. Analysis showed dropout rates for the exercise treatment were similar to those found in psychotherapeutic and drug interventions.
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References
Murray CJL, Lopez AD, editors. The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Global Burden of Disease and Injury Series, Vol. 1. Cambridge (MA): Harvard University Press, 1996
Ustun T, Satorisus N. Mental illness in general health care: an international study. New York: John Wiley, 1995: 323–34
Andrews G, Sanderson K, Corry J, et al. Using epidemiological data to model efficiency in reducing the burden of depression. J Mental Health Pol Econ 2000; 3 (4): 175–86
Trivedi M, Rush A, Wisniewski S, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STARD: implications for clinical practice. Am J Psychiatr 2000; 163: 28–40
Rush A, Trivedia M, Wisniewski S, et al. Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression. New Engl J Med 2006; 354: 1231–42
Trivedi M, Fava M, Wisniewski M, et al. Medication augmentation after the failure of SSRIs for depression. New Engl J Med 2006; 354: 1243–52
Minister for Health and Ageing. Exercise physiologists eligible to provide services under Medicare (ABB106/05) 2005, September 6 [online]. Available from URL: http://www.sport.gov.au/internet/ministers/publishing.nsf/con tent/ [Accessed 2009 Apr 1]
Mental Health Foundation. Up and running? Exercise therapy and the treatment of mild or moderate depression in primary care [online]. Available from URL: http://www.mentalhealth.org.uk/EasysiteWeb/getresource.axd?AssetID = 38660&type = Full&servicetype = Attachment [Accessed 2006 Nov 1]
Craft L, Landers D. The effect of exercise on clinical depression and depression resulting from mental illness: a meta-analysis. J Sport Exerc Psychol 1998; 20 (4): 339–57
Stich F. A meta-analysis of physical exercise as a treatment for symptoms of anxiety and depression [dissertation]. Madison (WI): University of Wisconsin-Madison, 1999
North T, McCullagh P, Tran Z. The effect of exercise on depression. Exerc Sport Sci Rev 1990; 18: 379–415
Guyatt G, Gutterman D, Baumann M, et al. Grading strength of recommendations and quality of evidence in clinical guidelines: report from an American College of Chest Physicians Task Force. Chest 2006; 129 (1): 174–81
Lawlor DA, Hopker SW. The effectiveness of exercise as an intervention in the management of depression: a systematic review and meta-regression analysis of randomized controlled trials [unabridged electronic version]. BMJ 2001; 322: 1–8 [online]. Available from URL: http://www.bmj.com/cgi/content/full/322/7289/
Schulz KF, Chalmers I, Hayes RJ, et al. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995; 273 (5): 408–12
Brosse A, Sheets E, Lett H, et al. Exercise and the treatment of clinical depression in adults: recent findings and future directions. Sport Med 2002; 32 (12): 741–60
Biddle S. The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials [online]. Available from URL: http://bmj.bmjjournals.com/cgi/eletters/322/7289/763 [Accessed 2006 Jul 13]
Mutrie N. The relationship between physical activity and clinically defined depression. In: Biddle S, Fox K, Boutcher S, editors. Physical activity and psychological well-being. London: Routledge, 2001: 46–63
Mutrie N. Healthy body, healthy mind? Psychologist 2002; 15 (8): 412–3
Callaghan P. Exercise: a neglected intervention in mental health care? J Psychiatr Mental Health Nurs 2004; 11 (4): 476–783
Stathopoulou G, Power M, Berry A, et al. Exercise interventions for mental health: a quantitative and qualitative review. Clin Psychol: Sci Pract 2006; 13 (2): 179–93
Hedges LV, Olkin I. Statistical methods for meta-analysis. Orlando (FL): Academic Press, 1985
Hunter JE, Schmidt FE. Methods of meta-analysis: correcting error and bias in research findings. Thousand Oaks (CA): Sage, 2004
Shadish WR, Haddock CK. Combining estimates of effect size. In: Cooper H, Hedges LV, editors. The handbook of research synthesis. New York: Russell Sage Foundation, 2004: 231–44
Higgins JPT, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analysis. BMJ 2003; 327: 557–60
Hedges LV. Fixed effects models. In: Cooper H, Hedges LV, editors. The handbook of research synthesis. New York: Russell Sage Foundation, 1994: 285–99
Powers SK, Howley ET. Exercise physiology: theory and applications to fitness and performance. New York: McGraw-Hill, 2003
Cohen J, Cohen P, West S, et al. Applied multiple regression/correlation analysis for the behavioral sciences. Mahwah (NJ): Lawrence Erlbaum Associates, 2003
Antunes HKM, Stella SG, Santos RF, et al. Depression, anxiety, and quality of life scores in seniors after an endurance exercise program. Rev Brasil Psiquiatr 2005; 27 (4): 266–71
Bartholomew J, Morrison D, Ciccolo J. Effects of acute exercise on mood and well-being in patients with major depressive disorder. Med Sci Sport Exerc 2005; 37 (12): 2032–7
Berger B, Friedmann E, Eaton M. Comparison of jogging, the relaxation response, and group interaction for stress reduction. J Sport Exerc Psychol 1988; 10 (4): 431–47
Blumenthal J, Emery C, Madden D, et al. Long-term effects of exercise on psychological functioning in older men and women. J Gerontol 1991; 46 (6): 352–61
Blumenthal J, Sherwood A, Babyak M, et al. Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial. JAMA 2005; 293 (13): 1626–34
Broocks A, Bandelow B, Pekrun G, et al. Comparison of aerobic exercise, clomipramine, and placebo in the treat ment of panic disorder. Am J Psychiatr 1998; 155 (5): 603–9
Brown MA, Goldstein-Shirley J, Robinson J, et al. The effects of a multi-modal intervention trial of light exercise and vitamins on women’s mood. Women Health 2001; 34 (3): 93–112
Burrus M. The effects of a running treatment program on depressed adolescents [dissertation]. Miami (FL): University of Miami, 1984
Castro CM, Wilcox S, O’Sullivan P, et al. An exercise program for women who are caring for relatives with dementia. Psychosom Med 2002; 64 (13): 458–68
Chin A Paw M, van Poppel NMN, et al. Effects of anaerobic exercise and all-around, functional training on quality of life, vitality, and depression of older adults living in long-term care facilities: a randomized controlled trial [abstract]. Biomed Central Geriatr 2004; 4: 5
Cramer SR, Nieman DC, Lee JW. The effects of moderate exercise training on psychological well-being and mood state in women. J Psychosom Res 1991; 35 (4–5): 437–49
Crews DJ, Lochbaum MR, Landers DM. Aerobic physical activity effects on psychological well-being in low-income Hispanic children. Percept Motor Skills 2004; 98 (1): 319–24
Deivert RG. Efficacy of an aerobic exercise program as treatment for depression and anxiety in alcohol and chemically dependent adults [dissertation]. State College (PA): Pennsylvania State University, 1990
DePalma MT. The effects of exercise on anxiety, depression, and type A behavior [dissertation]. Ithaca (NY): Cornell University, 1989
DiLorenzo TM, Bargman EP, Stucky-Ropp R, et al. Long-term effects of aerobic exercise on psychological outcomes. Prevent Med 1999; 28 (1): 75–85
Dugmore LD, Tipson RJ, Phillips MH, et al. Changes in cardiorespiratory fitness, psychological wellbeing, quality of life, and vocational status following a 12 month cardiac exercise rehabilitation programme. Heart 1999; 81 (4): 359–66
Dunn AL, Trivedi MH, Kampert JB, et al. Exercise treatment for depression: efficacy and dose response. Am J Prevent Med 2005; 28 (1): 1–8
Eby JM. An investigation into the effects of aerobic exercise on anxiety and depression [dissertation]. Toronto (ON): University of Toronto, 1984
Emery CF, Schein RL, Hauck ER, et al. Psychological and cognitive outcomes of a randomized trial of exercise among patients with chronic obstructive pulmonary Disease. Health Psychol 1998; 17 (3): 232–40
Epstein D. Aerobic activity versus group cognitive therapy: an evaluative study of contrasting interventions for the alleviation of clinical depression [dissertation]. Reno (NV): University of Nevada, 1986
Favilla G. The role of self-efficacy as a mediator in the relationship between muscle strength training and mood in the elderly [dissertation]. San Diego (CA): California School of Professional Psychology-San Diego, 1992
Gowans S, DeHueck A, Abbey S. Measuring exercise-induced mood changes in fibromyalgia: a comparison of several measures. Arthritis Rheum 2002; 47 (6): 603–9
Gowans SE, DeHueck A, Voss S, et al. Effects of a randomized, controlled trial of exercise on mood and physical function in individuals with fibromyalgia. Arthritis Care Res 2001; 45 (6): 519–29
Hembree L. Exercise and its effect on hopelessness and depression in an aging female population in Eastern Oklahoma [dissertation]. Fayetteville (AR): University of Arkansas, 2000
Hilyer JC, Wilson DG, Cillon C, et al. Physical fitness training and counseling as treatment for youthful offenders. J Counsel Psychol 1982; 29 (3): 292–303
Jorgensen C. Aerobic conditioning in the therapeutic treatment of chronic schizophrenia [dissertation]. Flagstaff (AZ): Northern Arizona University, 1986
Kanner KD. High versus low intensity exercise as part of an inpatient treatment program for childhood and adolescent depression [dissertation]. San Diego (CA): California School of Professional Psychology, 1990
King A, Taylor C, Haskell W. Effects of differing intensities and formats of 12 months of exercise training on psychological outcomes in older adults. Health Psychol 1993; 12 (4): 292–300
King AC, Taylor C, Haskell WL, et al. Influence of regular aerobic exercise on psychological health: a randomized, controlled trial of healthy middle-aged adults. Health Psychol 1989; 8 (3): 305–24
Klein MH, Greist JH, Gurman AS, et al. A comparative outcome study of group psychotherapy vs exercise treatments for depression. Int J Mental Health 1985; 13 (3–4): 148–76
Koukouvou G, Kouidi E, Iacovides A, et al. Quality of life, psychological, and physiological changes following exercise training in patients with chronic heart failure. J Rehabili Med 2004; 36 (1): 36–41
Lennox S, Bedell J, Stone A. The effect of exercise on normal mood. J Psychosom Res 1990; 34 (6): 629–36
Levin S. The effects of a ten-week jogging program as an adjunctive treatment for patients in a social rehabilitation clinic [dissertation]. Garden City (NY): Adelphi University, 1983
Martinsen E, Medhus A, Danvik L. Effects of aerobic exercise on depression: a controlled study [abstract]. BMJ 1985; 291 (6488): 109
McCann IL, Holmes DS. Influence of aerobic exercise on depression. J Personality Soc Psychol 1984; 46 (5): 1142–7
McNeil JK, LeBlanc EM, Joyner M. The effect of exercise on depressive symptoms in the moderately depressed elderly. Psychol Aging 1991; 6 (3): 487–8
Mutrie N. Exercise as a treatment for depression within the UK Health Service. Paper presented at Proceedings of the Sport, Health, Psychology and Exercise Symposium. London: The Sports Council, 1988
Neidig JL, Smith BA, Brashers DE. Aerobic exercise training for depressive symptom management in adults living with HIV infection. J Assoc Nurse AIDS Care 2003; 14 (2): 30–40
Newton M, Mutrie N, McArthur JD. The effects of exercise in a coronary rehabilitation programme. Scot Med J 1991; 38 (2): 38–41
Norris R, Carrol D, Cochrane R. The effects of physical activity and exercise training on psychological stress and well-being in an adolescent population. J Psychosom Res 1992; 36 (1): 55–65
Norvell N, Belles D. Psychological and physical benefits of circuit weight training in law enforcement personnel. J Consult Clin Psychol 1993; 61 (3): 520–7
Petajan JH, Gappmaier E, White AT, et al. Impact of aerobic training on fitness and quality of life in multiple sclerosis. Ann Neurol 1996; 39 (4): 432–41
Pierce TW, Madden DJ, Siegel WC, et al. Effects of aerobic exercise on cognitive and psychosocial functioning in patients with mild hypertension. Health Psychol 1993; 12 (4): 286–91
Pinchasov BB, Shurgaja AM, Grischin OV, et al. Mood and energy regulation in seasonal and non-seasonal depression before and after midday treatment with physical exercise or bright light. Psychiatr Res 2000; 94 (1): 29–42
Roth D, Homes D. Influence of aerobic exercise training and relaxation training on physical and psychologic health following stressful life events. Psychosom Med 1987; 49 (4): 355–65
Roth DL. Acute emotional and psychophysiological effects of aerobic exercise. Psychophysiology 1989; 25 (5): 593–602
Setaro JL. Aerobic exercise and group counseling in the treatment of anxiety and depression [dissertation]. College Park (MD): University of Maryland, 1985
Simons CW, Birkimer JC. An exploration of factors predicting the effects of aerobic conditioning on mood state. J Psychosom Res 1988; 32 (1): 63–75
Singh NA, Clements KM, Fiatarone MA. A randomized controlled trial of progressive resistance training in depressed elders. J Gerontol 1997; 52A(1): M27–35
Singh N, Clements KM, Fiatrone-Singh MA. The efficacy of exercise as a long-term antidepressant in elderly subjects: a randomized controlled trial. J Gerontol 2001; 56A(8): M497–504
Singh NA, Stavrinos TM, Scarbek Y, et al. A randomized controlled trial of high versus low intensity weight training versus general practitioner care for clinical depression in older adults. J Gerontol 2005; 60A(6): 768–76
Sorenson M, Anderssen S, Hjerman I, et al. The effect of exercise and diet on mental health and quality of life in middle-aged individuals with elevated risk factors for cardiovascular disease. J Sports Sci 1999; 17 (5): 369–77
Taylor MW. Effects of initial stress level, social support, and participation in an exercise or music condition on the post-treatment stress, depression, and anxiety of nurses [dissertation]. New York: St. John’s University, 1991
van den Berg-Emons R, Balk A, Bussmann H, et al. Does aerobic training lead to a more active lifestyle and improved quality of life in patients with chronic heart failure? Eur J Heart Fail 2004; 6: 95–100
Veale D, LeFevre K, Pantelis C, et al. Aerobic exercise in the adjunctive treatment of depression: a randomized controlled trial. J Royal Soc Med 1992; 85 (9): 541–4
Wigers S, Stiles T, Vogel P. Effects of aerobic exercise versus stress management treatment in fibromyalgia. Scand J Rheum 1996; 25 (2): 77–86
Williams P, Lord S. Effects of group exercise on cognitive functioning and mood in older women. Aust N Z J Pub Health 1997; 21 (1): 45–52
Wilson LM. The effects of an exercise conditioning program on reducing the stress response in nurses [dissertation]. Detroit (MI): Wayne State University, 1985
Zentner R. Psychological effects of a running program [dissertation]. Eugene (OR): University of Oregon, 1981
VandenHoek D. Long slow distance running as a treatment for moderate depression of outpatients [master’s thesis]. Kalamazoo (MI): Western Michigan University, 1983
Blumenthal J, Babyak M, Moore K. Effects of exercise on training on older patients with major depression. Arch Intern Med 1999; 159 (19): 2349–56
Herman S, Blumenthal JA, Babyak M, et al. Exercise therapy for depression in middle-aged and older adults: predictors of early dropout and treatment failure. Health Psychol 2002; 21 (6): 553–63
Fremont J, Craighead LW. Aerobic exercise and cognitive therapy in the treatment of dysphoric moods. Cognit Ther Res 1987; 11 (2): 241–51
Partonen T, Leppamaki S, Hurme J, et al. Randomized trial of physical exercise alone or combined with bright light on mood and health-related quality of life. Psychol Med 1998; 28 (6): 1359–64
Duman R, Heninger G, Nestler E. A molecular and cellular theory of depression. Arch Gen Psychiatr 1997; 54: 597–606
Malberg J, Eish A, Nestler E, et al. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000; 20 (24): 9104–10
Ernst C, Olson A, Pinel J, et al. Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis? J Psychiatr Neurosci 2006; 31 (2): 84–92
Persson A, Thorlin T, Bull C, et al. Mu- and delta-opioid receptor antagonists decrease proliferation and increase neurogenesis in cultures of rat adult hippocampal progenitors. Eur J Neurosci 2003; 17: 1159–72
Colt E, Wardlaw S, Frantz A. The effect of running on plasma delta-endorphin. Life Sci 1981; 28 (14): 1637–40
Schobersberger W, Hobisch-Hagen P, Fries D, et al. Increase in immune activation, vascular endothelial growth factor and erythropoietin after an ultramarathon run at moderate altitude. Immunobiology 2000; 201 (5): 611–20
Pereira A, Huddleston D, Brickman A, et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A 2007; 104 (13): 5638–43
Jin K, Zhu Y, Sun Y, et al. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci 2003; 99 (18): 11946–50
Fabel K, Fabel K, Tam B, et al. VEGF is necessary for exercise-induced adult hippocampal neurogenesis. Eur J Neurosci 2003; 18 (10): 2803–12
Cotman C, Berchtold N. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci 2002; 25 (6): 295–301
Wozniak W. Brain-derived neurotrophic factor (BDNF): role in neuronal development and survival. Folia Morphol 1993; 52 (4): 173–81
Russo-Neustadt A, Ha R, Ramirez R. Physical activityantidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model. Behav Brain Res 2001; 120: 87–95
Jacobs B. Serotonin motor activity, and depression-related disorders. Am Sci 1994; 82: 456–63
Chaouloff F, Laude D, Elghozi J. Physical exercise: evidence for differential consequences of tryptophan on 5-HT synthesis and metabolism in central serotonergic cell bodies and terminals. J Neural Transmission 1989; 78 (2): 1435–63
Brezun J, Daszuta A. Serotonin may stimulate granule cell proliferation in adult hippocampus, as observed in rats grafted with foetal raphe neurons. Eur J Neurosci 2000; 12: 391–6
Kubitz K, Landers D, Petruzzello S, et al. The effects of acute and chronic exercise on sleep. Sports Med 1996; 21 (4): 277–91
Youngstedt S, O’Connor P, Dishman R. The effects of acute exercise on sleep: a quantitative synthesis. Sleep 1997; 20 (3): 203–14
McGinty D, Harper R. Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res 1976; 101 (3): 569–75
Dietrich A, McDaniel W. Endocannabinoids and exercise. Br J Sport Med 2004; 3 (8): 536–41
Meng I, Manning B, Martin W, et al. An analgesia circuit activated by cannabinoids. Nature 1998; 395: 381–3
Sparling P, Giuffrida A, Piomelli D. Exercise activates the endocannabinoid system. Cognit Neurosci Neuropsychol 2003; 14 (17): 2209–11
Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 2000; 23 (5): 477–501
Wittert G, Livesey J, Espiner E, et al. Adaptation of the hypothalamopituitary adrenal axis to chronic exercise stress in humans. Med Sci Sport Exerc 1996; 28 (8): 1015–9
Dienstbier RA. Behavioral correlates of sympathoadrenal reactivity: the toughness model. Med Sci Sport Exerc 1991; 23 (7): 846–52
Luger A, Deuster PA, Kyle SB, et al. Acute hypothalamicpituitary-adrenal responses to the stress of treadmill exercise: physiologic adaptations to physical training. New Engl J Med 1987; 316 (21): 1309–15
Wittert GA, Livesey JH, Espiner EA, et al. Adaptation of the hypothalamopituitary adrenal axis to chronic exercise stress in humans. Med Sci Sport Exerc 1996; 28 (8): 1015–9
Blumenthal JA, Fredrikson M, Matthews KA, et al. Stress reactivity and exercise training in premenopausal and postmenopausal women. Health Psychol 1991; 10 (6): 384–91
Beyer C, Boikess S, Luo B, et al. Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study. J Psychopharmacol 2002; 16 (4): 297–304
Dishman R. Brain monoamines, exercise, and behavioral stress: animal models. Med Sci Sport Exerc 1997; 29 (1): 63–74
Ossip-Klein DJ, Doyne EJ, Bowman ED, et al. Effects of running or weight lifting on self-concept in clinically depressed women. J Consult Clin Psychol 1989; 57 (1): 158–61
Jacobsen N, Follette W, Revenstorf D. Psychotherapy outcome research: methods for reporting variability and evaluating clinical significance. Behav Ther 1984; 15 (4): 336–52
Seggar L, Lambert M, Hansen N. Assessing clinical significance: application to the Beck Depression Inventory. Behav Ther 2002; 33 (2): 253–69
Grundy C, Lambert M, Grundy E. Assessing clinical significance: application to the Hamilton Rating Scale for Depression. J Mental Health 1996; 5 (1): 25–33
McGlinchey JB, Atkins DC, Jacobsen NS. Clinical significance methods: which one to use and how useful are they. Behav Ther 2002; 33 (4): 529–50
Zipf G. Human behavior and the principle of least effort:an introduction to human ecology. Cambridge (MA): Addison-Wesley, 1949
Anderson I, Tomenson B. Treatment discontinuation with selective serotonin reuptake inhibitors compared with tricyclic antidepressants: a meta-analysis. BMJ 1995; 310: 1433–8
Montgomery S, Kasper S. Comparison of compliance between serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis. Int Clin Psychopharmacol 1995; 9 (4): 33–40
Steffens D, Krishnan K, Helms M. Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: a meta-analysis. Depress Anxiety 1997; 6: 10–8
Anderson I. SSRIs versus tricyclic antidepressants in depressed inpatients: a meta-analysis of efficacy and tolerability. Depress Anxiety 1998; 7 Suppl. 1: 11–7
Gloaguen V, Cottraux J, Cucherat M, et al. A metaanalysis of the effects of cognitive therapy in depressed patients. J Affect Disord 1998; 49 (1): 59–72
Food and Drug Administration. Sertaline hydrochloride patient information sheet 2006 [online]. Available from URL: http://www.fda.gov/cder/drug/InfoSheets/patient/sertralinePT.pdf [Accessed 2007 Jan 25]
US Department of Health and Human Services. Physical activity and health: a report of the Surgeon General. Atlanta (GA): US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, 1996
Warburton D, Nicol C, Bredin S. Health benefits of physical activity: the evidence. CMAJ 2006; 174 (6): 801–9
Taylor A, Cable N, Faulkner G, et al. Physical activity and older adults: a review of health benefits and the effectiveness of interventions. J Sport Sci 2004; 22 (8): 703–25
Kelly G, Kelly K, Tran Z. Exercise and bone mineral density in men: a meta-analysis. J Appl Physiol 2000; 88 (5): 1730–60
Department of Health and Aging. Exercise physiologists eligible to provide services under Medicare, 2005 [online]. Available from URL: http://www.health.gov.au/internet/ministers/publishing.nsf/Content/healthmediarel-yr2005-taabb106.htm [Accessed 2007 Jan 27]
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Rethorst, C.D., Wipfli, B.M. & Landers, D.M. The Antidepressive Effects of Exercise. Sports Med 39, 491–511 (2009). https://doi.org/10.2165/00007256-200939060-00004
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DOI: https://doi.org/10.2165/00007256-200939060-00004