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Penetration of Antibacterials into Bone

What Do We Really Need to Know for Optimal Prophylaxis and Treatment of Bone and Joint Infections?

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References

  1. Pea F, Viale P. The antimicrobial therapy puzzle: could pharmacokineticpharmacodynamic relationships be helpful in addressing the issue of appropriate pneumonia treatment in critically ill patients? Clin Infect Dis 2006 Jun 15; 42(12): 1764–71

    Article  PubMed  CAS  Google Scholar 

  2. Pea F, Viale P, Furlanut M. Antimicrobial therapy in critically ill patients: a review of pathophysiological conditions responsible for altered disposition and pharmacokinetic variability. Clin Pharmacokinet 2005; 44(10): 1009–34

    Article  PubMed  CAS  Google Scholar 

  3. Craig WA. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis 1998; 26(1): 1–10

    Article  PubMed  CAS  Google Scholar 

  4. Tegeder I, Schmidtko A, Brautigam L, et al. Tissue distribution of imipenem in critically ill patients. Clin Pharmacol Ther 2002; 71(5): 325–33

    Article  PubMed  CAS  Google Scholar 

  5. Joukhadar C, Frossard M, Mayer BX, et al. Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock. Crit Care Med 2001; 29(2): 385–91

    Article  PubMed  CAS  Google Scholar 

  6. Joukhadar C, Muller M. Microdialysis: current applications in clinical pharmacokinetic studies and its potential role in the future. Clin Pharmacokinet 2005; 44(9): 895–913

    Article  PubMed  CAS  Google Scholar 

  7. Mouton JW, Theuretzbacher U, Craig WA, et al. Tissue concentrations: do we ever learn? J Antimicrob Chemother 2008 Feb; 61(2): 235–7

    Article  PubMed  CAS  Google Scholar 

  8. Landersdorfer CB, Bulitta JB, Kinzig M, et al. Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations. Clin Pharmacokinet 2009; 48(2): 89–124

    Article  PubMed  CAS  Google Scholar 

  9. Drusano GL. Pharmacokinetics and pharmacodynamics of antimicrobials. Clin Infect Dis 2007 Jul 15; 45 Suppl. 1: S89–S95

    Article  PubMed  CAS  Google Scholar 

  10. Ette EI, Williams PJ, Lane JR. Population pharmacokinetics III: design, analysis, and application of population pharmacokinetic studies. Ann Phar-macother 2004 Dec; 38(12): 2136–44

    Article  Google Scholar 

  11. Plock N, Buerger C, Joukhadar C, et al. Does linezolid inhibit its own metabolism? Population pharmacokinetics as a tool to explain the observed nonlinearity in both healthy volunteers and septic patients. Drug Metab Dispos 2007 Oct; 35(10): 1816–23

    Article  PubMed  CAS  Google Scholar 

  12. Al-Nawas B, Kinzig-Schippers M, Soergel F, et al. Concentrations of piperacillin-tazobactam in human jaw and hip bone. J Craniomaxillofac Surg 2008 Dec; 36(8): 468–72

    Article  PubMed  Google Scholar 

  13. American Thoracic Society, Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005 Feb 15; 171(4): 388–416

    Article  Google Scholar 

  14. Tanaka A, Takada T, Kawarada Y, et al. Antimicrobial therapy for acute cholangitis: Tokyo guidelines. J Hepatobiliary Pancreat Surg 2007; 14(1): 59–67

    Article  PubMed  Google Scholar 

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Acknowledgements

No sources of funding were used to assist in the preparation of this commentary. The author has no conflicts of interest that are directly relevant to the content of this commentary.

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  1. Institute of Clinical Pharmacology & Toxicology, Department of Experimental and Clinical Pathology and Medicine, Medical School, University of Udine, Udine, Italy

    Federico Pea

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  1. Federico Pea
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Correspondence to Federico Pea.

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Pea, F. Penetration of Antibacterials into Bone. Clin Pharmacokinet 48, 125–127 (2009). https://doi.org/10.2165/00003088-200948020-00003

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