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Clinical Pharmacokinetics of the Third Generation Cephalosporins

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Summary

At the present time, the third generation cephalosporins that are already on the market or close to this point include cefsulodin, cefotaxime, cefoperazone, latamoxef, ceftriaxone, ceftazidime, ceftizoxime and cefotetan. Other newer compounds are also under development but have not been included in this review.

None of the third generation compounds is suitable for oral administration and, accordingly, their pharmacokinetics have been studied only after intravenous and intramuscular administration. Microbiological assays and HPLC methods have been used for the measurement of plasma/serum, urine, bile and cerebrospinal fluid (CSF) concentrations. As found with cefotaxime, microbiological assays should only be used when the full metabolite spectrum of a particular drug is known, as otherwise, the presence of microbiologically active metabolites may lead to erroneous conclusions.

Under normal conditions, the major route of elimination is via the kidneys for cefsulodin, latamoxef, ceftazidime, ceftizoxime and cefotetan. In contrast, cefoperazone is mainly eliminated in the bile, whereas cefotaxime and ceftriaxone depend both on the liver and the kidneys for their elimination. With the exception of ceftriaxone, which has a longer elimination half-life (i.e. around 8 hours), all the other third generation cephalosporins have a t1/2 ranging between 1.5 and 2.5 hours.

Plasma protein binding is variable from one compound to another. However, the clinical relevance of this parameter is not clearly established since tissue penetration also depends on the relative affinity of the drug for tissue components. Third generation cephalosporins seem to penetrate adequately into the CSF and, thus pharmacokinetically appear to be appropriate agents for the treatment of meningitis.

The degree of modification of pharmacokinetic parameters by renal insufficiency or hepatic diseases depends, as for other drugs, on the extent to which the compound is excreted via the kidneys or the liver. The third generation cephalosporins have been extensively studied under these conditions and recommendations for dosage modification in special circumstances are available for most of them. The pharmacokinetics of some third generation cephalosporins may be modified in neonates and elderly patients. Accordingly, their use at the extremes of age must be accompanied by a closer than usual clinical monitoring of the patient.

From a clinical point of view, the third generation cephalosporins possess reliable pharmacokinetic properties. The only limitation to their use thus centres around their antibacterial activity which is clearly superior to that of the older compounds as far as Gram-negative micro-organisms are concerned, but somewhat inferior against Gram-positive micro-organisms.

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References

  • Acar, F.; Guibert, J. and Kitzis, M.D.: Cinétique du céfotaxime chez le sujet normal. La Nouvelle Presse Médicale 10: 559–563 (1981).

    PubMed  CAS  Google Scholar 

  • Ackerman, B.H.; Ross, J.; Tofte, R.W. and Rotschafer, J.C.: Effect of decreased renal function on the pharmacokinetics of ceftazidime. Antimicrobial Agents and Chemotherapy 25: 785–786 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Ackers, I.M.; Myers, C.M. and Blumer, J.L.: Determination of cefsulodin in biological fluids by high-pressure liquid chromatography. Therapeutic Drug Monitoring 6: 91–95 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Adam, D. and Timmler, R.: Pharmakokinetik von Ceftizoxim mit und ohne Probenecid. Arzneimittel-Forschung 32: 416–419 (1982).

    PubMed  CAS  Google Scholar 

  • Adam, D.; Wittke, R.R. and Eisenberger, F.: Tissue penetration of cefsulodin, a new antipseudomonas-cephalosporin antibiotic. Drugs under Experimental and Clinical Research 7: 227–231 (1981).

    Google Scholar 

  • Adam, H.K.; Houghton, H.L.; Yates, R.A.; Young, J. and Donnelly, R.J.: Pharmacokinetics and tolerance of a 24-h infusion of cefotetan disodium (with and without loading dose) in normal Caucasian volunteers. Journal of Antimicrobial Chemotherapy 11 (Suppl.A): 193–199 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Ahrens, T.; Vischer, W.; Lmhof, P.; Füllhaas, J.; Zak, O. and Kradolfer, F.: Human pharmacology of CGP 7174/E (SCE-129) and initial results of clinical trials in Europe. Drugs under Experimental and Clinical Research 5: 61–70 (1979).

    CAS  Google Scholar 

  • Allaz, A.-F.; Dayer, P.; Fabre, J.; Rudhardt, M. and Balant, L.: Pharmacocinétique d’une nouvelle céphalosporine, la céfopérazone. Schweizerische Medizinische Wochenschrift 109: 1999–2005 (1979).

    PubMed  CAS  Google Scholar 

  • Andritz, M.H.; Smith, R.P.; Baltch, A.L.; Griffin, P.E.; Conroy, J.V.; Sutphen, N. and Hammer, M.C.: Pharmacokinetics of moxalactam in elderly subjects. Antimicrobial Agents and Chemotherapy 25: 33–36 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Angehrn, P.; Probst, P.J.; Reiner, R.; Then, R.L.: Ro 13-9904, a long acting broad-spectrum cephalosporin. Antimicrobial Agents and Chemotherapy 18: 913–921 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Aronoff, G.R.; Sloan, R.S.; Mong, S.A.; Luft, F.C. and Kleit, S.A.: Moxalactam pharmacokinetics during hemodialysis. Antimicrobial Agents and Chemotherapy 19: 575–577 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Arvidson, A.; Alvan, G.; Angelin, B.; Borgå, O. and Nord, C.E.: Ceftriaxone: Renal and biliary excretion and effect on the colon microflora. Journal of Antimicrobial Chemotherapy 10: 207–215 (1982).

    Article  Google Scholar 

  • Ascalone, V. and Dal Bò, L.: Determination of ceftriaxone, a novel cephalosporin, in plasma, urine and saliva by high performance liquid chromatography on an NH2 bonded-phase column. Journal of Chromatography — Biomedical Applications 273: 357–366 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Auckenthaler, R. and Waldvogel, F.A.: Wieviele Cephalosporine braucht der Kliniker?. Schweizerische Medizinische Wochenschrift 111: 1554–1556 (1981).

    PubMed  CAS  Google Scholar 

  • Ayrton, J.: Assay of ceftazidime in biological fluids using high-pressure liquid chromatography. Journal of Antimicrobial Chemotherapy 8 (Suppl. B): 227–231 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Bailey, R.R.; Peddie, B. and Blake, E.: Serum and urine concentrations of cefoperazone in severe chronic renal failure. Drugs 22 (Suppl. 1): 46–51 (1981a).

    Article  PubMed  Google Scholar 

  • Bailey, R.R.; Peddie, B.; Blake, E.; Bishop, V. and Reddy, J.: Cefoperazone in the treatment of severe or complicated infections. Drugs 22 (Suppl.1): 76–86 (1981b).

    Article  PubMed  Google Scholar 

  • Baird-Lambert, J.; Doyle, P.E.; Cvejic, T.M. and Buchanan, N.: Pharmacokinetics of cefotaxime in neonates. Journal of Antimicrobial Chemotherapy 13: 471–477 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Baker, S.; Wise, R.; Gillett, A.P. and Andrews, J.M.: Tissue penetration, as measured by a blister technique, and pharmacokinetics of CGP 7174/E compared with carbenicillin; in Nelson and Grassi (Eds) Current Chemotherapy and Infectious Diseases, Vol. 1, pp.647–649 (American Society for Microbiology, Washington DC 1980).

    Google Scholar 

  • Balant, L.: La clairance hépatique des médicaments dans l’insuffisance rénale. Néphrologie 4: 45–47 (1983).

    PubMed  CAS  Google Scholar 

  • Balant, L.; Dayer, P.; Rudhardt, M.; Allaz, A.F. and Fabre, J.: Cefoperazone: Pharmacokinetics in humans with normal and impaired renal function and pharmacokinetics in rats. Clinical Therapeutics 3 (Special Issue): 50–59 (1980).

    PubMed  CAS  Google Scholar 

  • Bang, N.U.; Tessler, S.S.; Heidenreich, R.O.; Marks, L.A. and Mattler, L.E.: Effects of moxalactam on blood coagulation and platelet function. Reviews of Infectious Diseases 4 (Suppl): S546–S554 (1982).

    Article  PubMed  Google Scholar 

  • Bauernfeind, A.: An evaluation of the activity of cephalosporins against Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy 8 (Suppl.B): 111–117 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Bax, R.; White, L.; Reeves, D.; Ings, R.; Bywater, M. and Holt, H.: Pharmacokinetics of HR 756 and its desacetyl metabolite. Abstract No. 882, 19th International Congress of Antimicrobial Agents and Chemotherapy, Boston (1979).

    Google Scholar 

  • Belaieff, J.; Cochet, B.; Allaz, A.-F.; Rudhardt, M.; Balant, L. and Fabre, J.: Etude pharmacocinétique d’une céphalosporine, la céfopérazone, dans l’insuffisance hépatique. Schweizerische Medizinische Wochenschrift 111: 502–508 (1981).

    PubMed  CAS  Google Scholar 

  • Benoni, G.; Arosio, E.; Raimondi, M.G.; Apolloni, E.; Passarella, E.; Lechi, A. and Velo, G.P.: Distribution of ceftazidime in ascitic fluid. Antimicrobial Agents and Chemotherapy 25: 760–763 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Bircher, J.: Hepatic drug disposition in the liver: Consequences for dosage adjustments; in Csomos and Thaler (Eds) Clinical Hepatology, History, Present State, Outlook, pp.45–51 (Springer Verlag, Berlin 1983).

    Google Scholar 

  • Boccazzi, A.; Rizzo, M.; Caccamo, M.L. and Assael, B.M.: Comparison of the concentrations of ceftazidime in the serum of newborn infants after intravenous and intramuscular administration. Antimicrobial Agents and Chemotherapy 24: 955–956 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Bodey, G.P.; Fainstein, V.; Garcia, I.; Rosenbaum, B. and Wong, Y.: Effect of broad-spectrum cephalosporins on the microbial flora of recipients. Journal of Infectious Diseases 148: 892–897 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Bolton, W.K.; Michael, W.M. and Meile, M.A.: Pharmacokinetics of cefoperazone in patients with renal insufficiency. Cefoperazone: A Clinical Review. Abstract of a paper presented at a symposium, New Orleans, Sept. 1980, p.8 (Excerpta Medica, Amsterdam 1980a).

    Google Scholar 

  • Bolton, W.K.; Scheid, W.M.; Spyker, D.A.; Overby, T.L. and Sande, M.A.: Pharmacokinetics of moxalactam in subjects with various degrees of renal dysfunction. Antimicrobial Agents and Chemotherapy 18: 933–938 (1980b).

    Article  PubMed  CAS  Google Scholar 

  • Boscia, J.A.; Korzeniowski, O.M.; Kobasa, W.D.; Rocha, H.; Levison, M.E. and Kaye, D.: Pharmacokinetics of cefoperazone in normal subjects and in patients with hepatosplenic schisto-somiasis. Journal of Antimicrobial Chemotherapy 12: 407–410 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Bouza, E.; Hellin. T.; Rodriguez-Creixems, M.; Martinez-Beltran, J.; Loza, E. and Baquero, F.: Comparison of ceftazidime concentrations in bile and serum. Antimicrobial Agents and Chemotherapy 24: 104–106 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Brogard, J.M.; Arnaud, J.P. and Timmler, R.: Biliary excretion of ceftizoxime in humans. Chemotherapy 30: 221–226 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Brogard, J.M.; Comte, F. and Pinget, M.: Pharmacokinetics of cephalosporin antibiotics; in Schönfeld (Ed.) Antibiotics and Chemotherapy, Vol. 25: Pharmacokinetics, pp. 123–162 S. Karger, Basel (1978).

    Google Scholar 

  • Brogden, R.N.; Carmine, A.; Heel, R.C.; Morley, P.A.; Speight, T.M. and Avery, G.S.: Cefoperazone: A review of its in vitro antimicrobial activity, pharmacological properties and therapeutic efficacy. Drugs 22: 423–460 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Brooks, G.F. and Barriere, S.L.: Clinical use of the new beta-lactam antimicrobial drugs. Practical considerations for physicians, microbiology laboratories, pharmacists, and formulary committees. Annals of Internal Medicine 98: 530–535 (1983).

    PubMed  CAS  Google Scholar 

  • Bruch, K.: Hypoprothrombinaemia and cephalosporins. Lancet 1: 535–536 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Brückner, O.; Collmann, H. and Borner, K.: Cefotaxime levels in ventricular cerebrospinal fluid, determined by bioassay and by high-performance liquid chromatography. Chemotherapy 29: 237–243 (1983).

    Article  PubMed  Google Scholar 

  • Bryskier, A. and Poletto, B.: La cefsulodine et l’infection à Pseudomonas aeruginosa. La Revue de Médecine 43: 2683–2688 (1981).

    Google Scholar 

  • Burgess, E.D. and Blair, A.D.: Pharmacokinetics of ceftizoxime in patients undergoing continuous ambulatory peritoneal dialysis. Antimicrobial Agents and Chemotherapy 24: 237–239 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Cable, D.; Edralin, G. and Overturf, G.D.: Human cerebrospinal fluid pharmacokinetics and treatment of bacterial meningitis with ceftizoxime. Journal of Antimicrobial Chemotherapy 10 (Suppl. C): 121–127 (1982).

    Article  PubMed  Google Scholar 

  • Cable, D.; Overturf, G. and Edralin, G.: Concentrations of cefoperazone in cerebrospinal fluid during bacterial meningitis. Antimicrobial Agents and Chemotherapy 23: 688–691 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Carlberg, H.; Alestig, K.; Nord, C.E. and Trollfors, B.: Intestinal side effects of cefoperazone. Journal of Antimicrobial Chemotherapy 10: 483–487 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Carmine, A.A.; Brogden, R.N.; Heel, R.C.; Speight, T.M. and Avery, G.S.: Cefotaxime. A review of its activity, pharmacological properties and therapeutic use. Drugs 25: 223–289 (1983a).

    Article  PubMed  CAS  Google Scholar 

  • Carmine, A.A.; Brogden, R.N.; Heel, R.C.; Romankiewicz, J.A.; Speight, T.M. and Avery, G.S.: Moxalactam (latamoxef). A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 26: 279–333 (1983b).

    Article  PubMed  CAS  Google Scholar 

  • Chamberlain, J.; Coombes, J.D.; Dell, D.; Fromson, J.M.; Ings, R.J.; Macdonald, C.M. and McEwen, J.: Metabolism of cefotaxime in animals and man. Journal of Antimicrobial Chemotherapy 6 (Suppl. A): 69–78 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Chartrand, S.A.; Marks, M.I.; Johnston, J.T.; Frederick, D.F. and Scribner, R.K.: Cefoperazone pharmacokinetics in acute childhood meningitis. Journal of Pediatrics 103: 991–995 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Cherubin, C.E.; Corrado, M.L.; Nair, S.R.; Gombert, M.E.; Landesman, S. and Humbert, G.: Treatment of Gram-negative bacillary meningitis: Role of the new cephalosporin antibiotics. Reviews of Infectious Diseases 4 (Suppl.): S453–S464 (1982).

    Article  PubMed  Google Scholar 

  • Chodos, J.; Francke, E.L.; Saltzman, M. and Neu, H.C.: Pharmacokinetics of intravenous cefotaxime in patients undergoing chronic hemodialysis. Therapeutic Drug Monitoring 3: 71–74 (1981).

    PubMed  CAS  Google Scholar 

  • Cochet, B.; Belaieff, J.; Allaz, A.-F.; Rudhardt, M.; Balant, L. and Fabre, J.: Decreased extrarenal clearance of cefoperazone in hepatocellular diseases. British Journal of Clinical Pharmacology 11: 389–390 (1981a).

    Article  PubMed  CAS  Google Scholar 

  • Cochet, B.; Belaieff, J.; Allaz, A.-F.; Rudhardt, M.; Balant, L. and Fabre, J.: Serum levels and urinary excretion of cefoperazone in patients with hepatic insufficiency. Infection 9 (Suppl. 1): 37 (1981b).

    Article  CAS  Google Scholar 

  • Cohen, D.; Appel, G.B.; Scully, B. and Neu, H.C.: Pharmacokinetics of ceftriaxone in patients with renal failure and in those undergoing hemodialysis. Antimicrobial Agents and Chemotherapy 24: 529–532 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Congeni, B.L.: Comparison of ceftriaxone and traditional therapy of bacterial meningitis. Antimicrobial Agents and Chemotherapy 25: 40–44 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Coombes, J.D.: Metabolism and pharmacokinetics of the newer cephalosporins: Cefotaxime, ceftizoxime, ceftriaxone, ceftazidime, cefoperazone, moxalactam and cefsulodin; in Neu (Ed.) New Beta-lactam Antibiotics: A review from Chemistry to Clinical Efficacy of the New Cephalosporins, pp. 177–214 (Francis Clark Wood Institute for History of Medicine, Philadelphia 1982a).

    Google Scholar 

  • Coombes, J.D.: Metabolism of cefotaxime in animals and humans. Reviews of Infectious Diseases 4 (Suppl.): S325–S332 (1982b).

    Article  PubMed  Google Scholar 

  • Costanzo, E.; Falsaperla, A.; Pennisi, G.; Samperi, R. and Gismondo, M.R.: Cefoperazone: Blood and CSF levels in patients with inflamed and uninflamed haematoencephalic barriers. Drugs Under Experimental and Clinical Research 10: 39–41 (1984).

    Google Scholar 

  • Craig, W.A.: Single-dose pharmacokinetics of cefoperazone following intravenous administration. Clinical Therapeutics 3 (Special Issue): 46–49 (1980).

    PubMed  CAS  Google Scholar 

  • Craig, W.A.; Greenfield, R.A. and Gerber, A.V.: Pharmacokinetics of cefoperazone in patients with normal and impaired hepatic and renal function. Abstract of a paper presented at a symposium on cefoperazone, Geneva, Oct. 4–5 (1981).

  • Cunha, B.A.; Ristuccia, A.M.; Jonas, M.; Ristuccia, P.A. and Janelli, D.E.: Tissue penetration characteristics of ceftizoxime and cefazolin in human bile and gallbladder wall. Journal of Antimicrobial Chemotherapy 10 (Suppl. C): 117–120 (1982).

    Article  PubMed  Google Scholar 

  • Curtis, N.A.C.; Orr, D.; Ross, G.W. and Boulton, M.G.: Affinities of penicillins and cephalosporins for the penicillin-binding proteins of Escherichia coli K-12 and their antibacterial activity. Antimicrobial Agents and Chemotherapy 16: 533–539 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Cutler, R.E.; Blair, A.D.; Burgess, E.D. and Parks, D.: Pharmacokinetics of ceftizoxime. Journal of Antimicrobial Chemotherapy 10 (Suppl. C): 91–97 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Dayer, P.; Balant, L.; Rudhardt, M.; Allaz, A.F. and Fabre, J.: Behaviour of cefoperazone (a new cephalosporin) in man: Influence of renal insufficiency. Kidney International 17: 857 (1980).

    Google Scholar 

  • Dayer, P.; Balant, L.; Fabre, J.; Rudhardt, M. and Allaz, A.-F.: Renal and extrarenal clearances of cefoperazone in patients with renal failure. International Journal of Clinical Pharmacology Research 1: 233–244 (1981).

    Google Scholar 

  • Del Rio, M.; McCracken, G.H.; Nelson, J.D.; Chrane, D. and Shelton, S.: Pharmacokinetics and cerebrospinal fluid bactericidal activity of ceftriaxone in the treatment of pediatric patients with bacterial meningitis. Antimicrobial Agents and Chemotherapy 22: 622–627 (1982).

    Article  PubMed  Google Scholar 

  • Delsignore, R.; Baroni, C.M.; Crotti, G.; Mineo, F.; Butturini, U.; Ascalone, V. and Cisternino, M.: Absolute bioavailability of ceftriaxone after intramuscular administration to healthy volunteers. Chemotherapy 29: 157–162 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Diven, W.F.; Obermeyer, B.D.; Wolen, R.L.; Yu, V.L.; Lyon, J. and Zuravleff, J.: Measurement of serum and tissue concentration of moxalactam using high pressure liquid chromatography. Therapeutic Drug Monitoring 3: 291–295 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Doluisio, J.T.: Clinical pharmacokinetics of cefotaxime in patients with normal and reduced renal function. Reviews of Infectious Diseases 4 (Suppl.): S333–S345 (1982).

    Article  PubMed  Google Scholar 

  • Dubb, J.; Actor, P.; Pitkin, D.; Alexander, F.; Familiar, R.; Ehrlich, S. and Stote, R.: Ceftizoxime kinetics and renal handling. Clinical Pharmacology and Therapeutics 31: 516–521 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Dunn. G.L.: Ceftizoxime and other third-generation cephalosporins: Structure-activity relationship. Journal of Antimicrobial Chemotherapy 10 (Suppl. C): 1–10 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Durack, D.T. and Perfect, J.R.: Potential value of cefoperazone in bacterial meningitis: Experimental studies. Drugs 22 (Suppl. 1): 60–64 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Durham, S.R. and Wise, R.: Human pharmacology and tissue levels of CGP 7174/E: A new antipseudomonal cephalosporin. Journal of Antimicrobial Chemotherapy 6: 743–747 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Elenbass, R.M.; Ryan, J.L.; Robinson, W.A.; Singsank, M.J.; Harvey, M.J. and Klaasen, C.D.: On the disulfiram-like activity of moxalactam. Clinical Pharmacology and Therapeutics 32: 347–355 (1982).

    Article  Google Scholar 

  • Ellis-Pegler, R.B. and Lang, S.D.: Cefoperazone in Klebsiella meningitis: A case report. Drugs 22 (Suppl. 1): 69–71 (1981).

    Article  PubMed  Google Scholar 

  • Elrod, Jr., L.; White, L.B.; Wimer, D.C. and Cox, R.D.: Determination of cefsulodin sodium (D(−)-SCE-129) by high performance liquid chromatography. Journal of Chromatography 237: 515–521 (1982).

    Article  CAS  Google Scholar 

  • Esmieu, F.; Guibert, J.: Rosenkilde, H.C.; Ho, I. and Le Go, A.: Pharmacokinetics of cefotaxime in normal human volunteers. Journal of Antimicrobial Chemotherapy 6 (Suppl. A): 83–92 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Estey, E.H.; Weaver, S.S.; Ho, D.H.W. and Bodey, G.P.: Clinical pharmacology of moxalactam in patients with malignant disease. Antimicrobial Agents and Chemotherapy 19: 639–644 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Fabre, J.; Fox, H.M.; Dayer, P. and Balant, L.: Differences in kinetic properties of drugs: Implications as to the selection of a particular drug for use in patients with renal failure, with special emphasis on antibiotics and β-adrenoceptor blocking agents. Clinical Pharmacokinetics 5: 441–464 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Farquet, Ch.; Marti, M.C.; Balant, L.; Cochet, B.; Rudhardt, M.; Fabre, J. and Rohner, A.: Etude pharmacocinétique d’une céphalosporine: la céfopérazone chez des patients porteurs d’un drain de Kehr. Schweizerische Medizinische Wochenschrift 112: 123–129 (1982).

    PubMed  CAS  Google Scholar 

  • Fasching, C.E. and Peterson, L.R.: Anion-exchange extraction of cephapirin, cefotaxime, and cefoxitin from serum for liquid chromatography. Antimicrobial Agents and Chemotherapy 21: 628–633 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Fasching, C.E.; Peterson, L.R.; Bettin, K.M. and Gerding, D.N.: High-pressure liquid Chromatographic assay of ceftizoxime with an anion-exchange extraction technique. Antimicrobial Agents and Chemotherapy 22: 336–337 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Fillastre, J.P.; Humbert, G.; Leroy, A. and Godin, M.: Pharmacocinétique des nouvelles céphalosporines. Journées de l’Hôpital Claude-Bernard, pp. 233–272 (1981a).

  • Fillastre, J.P.; Humbert, G.; Olier, B.; Leguy, F.; Borsa, F. and Spenser, G.R.: Pharmacokinetics of ceftazidime in renal failure. Journal of Antimicrobial Chemotherapy 11: 487–488 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Fillastre, J.P.; Ings, R.M.J.; Leroy, A.; Godin, M. and Humbert, G.: Pharmacocinétique du cefotaxime et de ses métabolites chez les malades insuffisants rénaux. Néphrologie 3: 12–18 (1982).

    PubMed  CAS  Google Scholar 

  • Fillastre, J.P.; Ings, R.M.J.; Leroy, A.; Humbert, G. and Godin, M.: Pharmacocinétique du céfotaxime chez les insuffisants rénaux chroniques. La Nouvelle Presse Médicale 10: 574–579 (1981b).

    PubMed  CAS  Google Scholar 

  • Fillastre, J.P.; Leroy, A.; Humbert, G. and Godin, M.: Pharmacokinetics of cefotaxime in subjects with normal and impaired renal function. Journal of Antimicrobial Chemotherapy 6 (Suppl. A): 103–111 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Findlay, C.D.; Wise, R.; Allcock, J.E. and Durham, S.R.: The tissue penetration, as measured by a blister technique, and pharmacokinetics of cefsulodin compared with carbenicillin and ticarcillin. Journal of Antimicrobial Chemotherapy 7: 637–642 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Fisher, J.F.; Carter, M.J.; Parsons, J. and Rissing, J.P.: Moxalacta (LY 127935) in treatment of meningitis due to Gram-negative bacilli. Antimicrobial Agents and Chemotherapy 19: 218–221 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Fitzpatrick, B.J. and Standiford, H.C.: A comparative evaluation of moxalactam: Antimicrobial activity, pharmacokinetics, adverse reactions, and clinical efficacy. Pharmacotherapy 2: 197–212 (1982).

    PubMed  CAS  Google Scholar 

  • Fong, I.W. and Tomkins, K.B.: Penetration of ceftazidime into the cerebrospinal fluid of patients with and without evidence of meningeal inflammation. Antimicrobial Agents and Chemotherapy 26: 115–116 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Foster. T.; Raehl, C. and Wilson, H.: Disulfiram-like reaction associated with a parenteral cephalosporin. American Journal of Hospital Pharmacy 37: 858–859 (1980).

    PubMed  CAS  Google Scholar 

  • Fu, K.P.; Aswapokee, P.; Ho, I.; Matthijssen, C. and Neu, H.C.: Pharmacokinetics of cefotaxime. Antimicrobial Agents and Chemotherapy 16: 592–597 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Fu, K.P. and Neu, H.C.: Antibacteroides and β-lactamase inhibitory activities of moxalactam. Journal of Antimicrobial Chemotherapy 8: 337–341 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Fujita, K.; Sakata, H. and Yoshioka, H.: Diarrhoea and annihilation of faecal flora associated with cefpiramide. Lancet 1: 423–424 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Funk, E.A. and Strausbaugh, L.J.: Antimicrobial activity, pharmacokinetics, adverse reactions, and therapeutic indications of cefoperazone. Pharmacotherapy 2: 185–196 (1982).

    PubMed  CAS  Google Scholar 

  • Gallop, P.M.; Lian, J.B. and Hauschka, P.V.: Carboxylated calcium binding proteins and vitamin K. New England Journal of Medicine 302: 1460–1466 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Garcia, I.; Fainstein, V.; Smith, R.G. and Bodey, G.P.: Multiple-dose pharmacokinetics of ceftazidime in cancer patients. Antimicrobial Agents and Chemotherapy 24: 141–144 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Garzone, P.; Lyon, J.; Yu, V.L.; Zuravleff, J.; Diven, W. and Pasculle, W.: Steady-state moxalactam kinetics: Comparison with other cephalosporins. Clinical Pharmacology and Therapeutics 30: 86–94 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Giamarellou, H.; Koumaditis, A.; Dispiraki, K.; Xefteri, H. and Daikos, G.K.: Therapeutic effectiveness and pharmacokinetics of cefsulodin in multi-resistant Pseudomonas aeruginosa infections. Drugs under Experimental and Clinical Research 7: 219–226 (1981a).

    Google Scholar 

  • Giamarellou, H.; Koumaditis, A. and Daikos, G.K.: Cefsulodin kinetics in renal failure including the effects of dialysis. Drugs under Experimental and Clinical Research 7: 425–429 (1981b).

    Google Scholar 

  • Giamarellou, H.J.; Tsagarakis, J.; Petrikkos, G.; Mavroudis, K.; Veldekis, D. and Daikos. G.K.: Ceftriaxone: Therapeutic results in various infections and kinetic studies. Arzneimittel-Forschung 34: 321–325 (1984).

    PubMed  CAS  Google Scholar 

  • Gibaldi, M. and Perrier, D.: Pharmacokinetics, p.329 (Marcel Dekker, New York 1975).

    Google Scholar 

  • Gibson, T.P.; Granneman, G.R.; Kallal, J.E. and Sennello, L.T.: Cefsulodin kinetics in renal impairment. Clinical Pharmacology and Therapeutics 31: 602–608 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Gilchrist, M.J.R. and Washington, J.A.: In vitro activity of moxalactam against anaerobic bacteria. Reviews of Infectious Diseases 4 (Suppl): S511–S515 (1982).

    Article  PubMed  Google Scholar 

  • Gillette, J.R.: Factors affecting drug metabolism. Annals of the New York Academy of Sciences 179: 43–66 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Glöckner, W.M.; Höffler, U.; Kindler, J.; Peters, G. and Sieberth, H.G.: Elimination kinetics of cefotaxime in patients with renal insufficiency requiring dialysis. Journal of Antimicrobial Chemotherapy 6 (Suppl. A): 219–223 (1980).

    Article  PubMed  Google Scholar 

  • Glöckner, W.M.; Peters, G.; Frisch, J. and Kindler, J.: Pharmacokinetics of cefsulodin in patients with severe renal failure. International Journal of Clinical Pharmacology Research 2: 255–258 (1982).

    Google Scholar 

  • Goto, S.: In vitro and in vivo antibacterial activity of moxalactam, an oxa-β-lactam antibiotic. Reviews of Infectious Diseases 4 (Suppl.): S501–S510 (1982).

    Article  PubMed  Google Scholar 

  • Goto, S.; Ogawa, M.; Kaneko, Y.; Kuwahara, S.; Tsuchiya, K.; Kondo, M.; Nishi, T. and Nagatomo, H.: SCE-129, a new antipscudomonal cephalosporin; in vitro and in vivo antibacterial activity: in Siegenthaler and Lüthy (Eds) Current Chemotherapy Vol. 2, pp.835–838 American Society for Microbiology, Washington, DC (1978).

    CAS  Google Scholar 

  • Gower. P.E.; Hobbs, P.M. and Harding, S.M.: Kinetics of ceftazidime in renal impairment; in Periti and Grassi (Eds) Current Chemotherapy and Immunotherapy, Vol. 1, pp.498–499 (American Society for Microbiology, Washington, DC 1982).

    Google Scholar 

  • Granneman, G.R. and Sennello, L.T.: Precise high-performance liquid Chromatographic procedure for the determination of cefsulodin, a new antipseudomonal cephalosporin antibiotic, in plasma. Journal of Pharmaceutical Sciences 71: 1112–1115 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Granneman, G.R.; Sennello, L.T.; Sonders, R.C.; Wynne, B. and Thomas, E.W.: Cefsulodin kinetics in healthy subjects after intramuscular and intravenous injection. Clinical Pharmacology and Therapeutics 31: 95–103 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Greenwood, D. and Eley, A.: Comparative antipseudomonal activity of some newer β-lactam agents. Antimicrobial Agents and Chemotherapy 21: 204–209 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Gross, M.L.; Somani, P.; Ribner, B.S.; Raeader, R.; Freimer, E.H. and Higgins, J.T.: Ceftizoxime elimination kinetics in continuous ambulatory peritoneal dialysis. Clinical Pharmacology and Therapeutics 34: 673–680 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Guibert, J.; Kitzis, M.D.; Tancrede, C.; Motin, J.; Esmieu, F.; Husson, J.M. and Acar, J.F.: Première étude pharmacocinétique et thérapeutique sur une nouvelle céphalosporine: Le cefotaxime. Médecine et Maladies Infectieuses 10: 156–162 (1980).

    Article  Google Scholar 

  • Guibert, J.; Kitzis, M.D.; Yvelin, C. and Acar, J.F.: Pharmacokinetics of single intravenous and intramuscular doses of cefotetan in normal human volunteers. Journal of Antimicrobial Chemotherapy 11 (Suppl. A): 201–206 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Harding, S.M.: Clinical pharmacology of ceftazidime; in Periti and Grassi (Eds) Current Chemotherapy and Immunotherapy, Vol. 1, pp.495–498 (American Society for Microbiology, Washington, DC 1982).

    Google Scholar 

  • Harding, S.M.; Ayrton, J.; Thornton, J.E.; Munro, A.J. and Hogg, M.I.J.: Pharmacokinetics of ceftazidime in normal subjects. Journal of Antimicrobial Chemotherapy 8 (Suppl. B): 261 (1981a).

    Article  PubMed  Google Scholar 

  • Harding, S.M. and Harper, P.B.: The pharmacokinetic behaviour of ceftazidime in man and the relationship between serum levels and the in vitro susceptibility of clinical isolates. Infection 11 (Suppl. 1): S49–S53 (1983).

    Article  PubMed  Google Scholar 

  • Harding, S.M.; Monro, A.J.; Thornton, J.E.; Ayrton, J. and Hogg, M.I.J.: The comparative pharmacokinetics of ceftazidime and cefotaxime in healthy volunteers. Journal of Antimicrobial Chemotherapy 8 (Suppl. B): 263–272 (1981b).

    Article  PubMed  CAS  Google Scholar 

  • Harvengt, C.; Wauters, G. and Meunier, H.: Cefotaxime kinetics after multiple-dose intramuscular study in healthy volunteers. Chemotherapy 27: 173–178 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Hinkle, A.M.; LeBlanc, B.M. and Bodey, G.P.: In vitro evaluation of cefoperazone. Antimicrobial Agents and Chemotherapy 17: 423–427 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Hodler, J.E.; Galeazzi, R.L.; Frey, B.; Rudhardt, M. and Seiler, A.J.: Pharmacokinetics of cefoperazone in patients undergoing chronic ambulatory peritoneal dialysis. Clinical and pathophysiological implications. European Journal of Clinical Pharmacology 26: 609–612 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Höffken, G.; Lode, H.; Koeppe, P.; Ruhnke, M. and Borner, K.: Pharmacokinetics of cefotaxime and desacetyl-cefotaxime in cirrhosis of the liver. Chemotherapy 30: 7–17 (1984).

    Article  PubMed  Google Scholar 

  • Höffler, D.; Koeppe, P. and Moecke, D.: On the pharmacokinetics of latamoxef in normal and impaired renal function. Arzneimittel-Forschung 34: 317–320 (1984b).

    PubMed  Google Scholar 

  • Höffler, D.; Koeppe, P. and Piper, C.: The pharmacokinetics of cefoperazone in normal and impaired renal function. Infection 9 (Suppl. 1): 24 (1981).

    Article  Google Scholar 

  • Höffler, D.; Koeppe, P. and Williams, K.J.: Pharmacokinetics of ceftazidime in normal and impaired renal function. Arzneimittel-Forschung 34: 72–76 (1984a).

    PubMed  Google Scholar 

  • Hoffstedt, B. and Walder, M.: Penetration of ceftazidime into extracellular fluid in patients. Journal of Antimicrobial Chemotherapy 8 (Suppl. B): 289–292 (1981).

    Article  PubMed  Google Scholar 

  • Humbert, G.; Kazmierczak, A.; Borsa, F. and Pechinot, A.: Concentrations of cefoperazone in cerebrospinal fluid of patients with bacterial meningitis. Proceedings of the 13th International Congress of Chemotherapy, Vienna, Austria, 28 August–2 September 1983, pp.335–339 (1983a).

    Google Scholar 

  • Humbert, G.; Lemeland, J.F. and Leroy, A.: Les céphalosporines de troisième génération. Cahiers Médicaux 17: 1007–1011 (1983b).

    Google Scholar 

  • Humbert, G.; Leroy, A. and Fillastre, J.P.: Pharmacocinétique de moxalactam chez l’adulte. Semaine des Hôpitaux de Paris 59: 1963–1967 (1983c).

    PubMed  CAS  Google Scholar 

  • Humbert, G.; Leroy, A.; Nair, S.R. and Cherubin, C.E.: Concentrations of cefotaxime and the desacetyl metabolite in serum and CSF of patients with meningitis. Journal of Antimicrobial Chemotherapy 13: 487–494 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Ings, R.M.J.; Fillastre, J.P.; Godin, M.; Leroy, A. and Humbert, G.: The pharmacokinetics of cefotaxime and its metabolites in subjects with normal and impaired renal function. Reviews of Infectious Diseases 4 (Suppl.): S379–S391 (1982).

    Article  PubMed  Google Scholar 

  • Itakura, K.; Mitani, M.; Aok, I. and Usui, Y.: High performance liquid chromatography assay of cefsulodin, cefotiam and cefmenoxime in serum and urine. Chemical and Pharmaceutical Bulletin 30: 622–627 (1982).

    Article  CAS  Google Scholar 

  • Jacobson, E.J.; Zahrowski, J.J. and Nissenson, A.R.: Moxalactam kinetics in hemodialysis. Clinical Pharmacology and Therapeutics 30: 487–490 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Jones, R.N. and Thornsberry, C.: Cefotaxime: A review of in vitro antimicrobial properties and spectrum of activity. Reviews of Infectious Diseases 4 (Suppl.): S300–S315 (1982).

    Article  PubMed  Google Scholar 

  • Kafetzis, D.A.; Brater, D.C.; Kapiki, A.N.; Papas, C.V.; Deliagrammatics, H. and Papadatos, C.J.: Treatment of severe neonatal infections with cefotaxime. Efficacy and pharmacokinetics. Journal of Pediatrics 100: 483–489 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Kampf, D.; Borner, K.; Möller, M. and Kessel, M.: Kinetic interactions between azlocillin, cefotaxime and cefotaxime metabolites in normal and impaired renal function. Clinical Pharmacology and Therapeutics 35: 214–220 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Kaplan, S.L.; Mason, E.O.; Garcia, H.; Kvernland, S.J.; Loiselle, E.M.; Anderson, D.C.; Mintz, A.A. and Feigin, R.D.: Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis. Journal of Pediatrics 98: 152–157 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Karimi, A.; Seeger, K.; Stolke, D. and Knothe, H.: Cefotaxime concentration in cerebrospinal fluid. Journal of Antimicrobial Chemotherapy 6 (Suppl. A): 119–120 (1980).

    Article  PubMed  Google Scholar 

  • Kees, F.; Strehl, E.; Dominiak, P.; Grobecker, H.; Seeger, K.; Seidel, G.; Neuhaus, B. and Safrany L.: Cefotaxime and desacetyl cefotaxime in human bile. Infection II: 118–120 (1983).

    Article  Google Scholar 

  • Keller, E.; Jansen, A.; Pelz, K.; Hoppe-Seyler, G. and Schollmeyer, P.: Intraperitoneal and intravenous cefoperazone kinetics during continuous ambulatory peritoneal dialysis. Clinical Pharmacology and Therapeutics 35: 208–213 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Kemmerich, B.; Lode, H.; Belmega, G.; Jendroschek, T.; Borner, K. and Koeppe, P.: Comparative pharmacokinetics of cefoperazone, cefotaxime and moxalactam. Antimicrobial Agents and Chemotherapy 23: 429–434 (1983a).

    Article  PubMed  CAS  Google Scholar 

  • Kemmrich, B.; Lode, H.; Borner, K.; Belmega, D.; Jendroschek, T.; Koeppe, P. and Goertz, G.: Biliary excretion and pharmacokinetics of cefoperazone in humans. Journal of Antimicrobial Chemotherapy 12: 27–37 (1983b).

    Article  Google Scholar 

  • Kemmerich, B.; Warns, H.; Lode, H.; Borner, K.; Koeppe, P. and Knothe, H.: Multiple-dose pharmacokinetics of ceftazidime and its influence on fecalflora. Antimicrobial Agents and Chemotherapy 24: 333–338 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Kowalsky, S.F.; Echols, R.M.; Venezia, A.R. and Andrews, E.A.: Pharmacokinetics of ceftizoxime in subjects with various degrees of renal function. Antimicrobial Agents and Chemotherapy 24: 151–155 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Klein, O.J.: Pharmacokinetics of cefoperazone in infants and children. Proceedings of the 6th International Cefoperazone Symposium, Tokyo, April–May 1982, pp.91–96 (Excerpta Medica, Amsterdam 1983).

    Google Scholar 

  • Krasinski, K. and Nelson, J.D.: Pharmacokinetics and efficacy of ceftazidime in experimental Haemophilus influenzae b meningitis. Journal of Antimicrobial Chemotherapy 8 (Suppl. B): 339–343 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Lam, M.; Manion, C.V. and Czerwinski, A.W.: Pharmacokinetics of moxalactam in patients with renal insufficiency. Antimicrobial Agents and Chemotherapy 19: 461–464 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Landesman, S.H.; Corrado, M.L.; Cherubin, C.C.; Gombert, M. and Cleri, D.: Diffusion of a new beta-lactam (LY 127935) into cerebrospinal fluid. Implications for therapy of Gram-negative bacillary meningitis. American Journal of Medicine 69: 92–98 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Landesman, S.H.; Corrado, M.L.; Shah, P.M.; Armengaud, M.; Barza, M. and Cherubin, C.E.: Past and current roles for cephalosporin antibiotics in treatment of meningitis. American Journal of Medicine 71: 693–703 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Lassman, H.B. and Coombes, J.D.: Metabolism of cefotaxime: a review. Diagnostic Microbiology and Infectious Disease 2: 3S–12S (1984).

    PubMed  CAS  Google Scholar 

  • Latif, R. and Dajani, A.S.: Ceftriaxone diffusion into cerebrospinal fluid of children with meningitis. Antimicrobial Agents and Chemotherapy 23: 46–48 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Lecaillon, J.B.; Rouan, M.C.; Souppart, C.; Ferre, N. and Juge, F.: Determination of cefsulodin, cefotiam, cephalexin, cefotaxime, desacetyl-cefotaxime, cefuroxime and cefroxadin in plasma and urine by HPLC. Journal of Chromatography 228: 257–267 (1982).

    Article  PubMed  CAS  Google Scholar 

  • LeFrock, J.L.; Prince, R.A. and Leff, R.D.: Mechanism of action, antimicrobial activity, pharmacology, adverse effects and clinical efficacy of cefotaxime. Pharmacotherapy 2: 174–184 (1982).

    PubMed  CAS  Google Scholar 

  • Leroy, A.; Esmieu, A.; Fillastre, J.P.; Fleurette, J.; Houin, G.; Humbert, G.; Lagrue, G.; Lhoste, F.; Le Go, A.; Soussy, C.J. and Zech, P.: The cephalosporin HR 756: Pharmacokinetics in healthy adult volunteers and in patients with chronic renal failure. Drugs under Experimental and Clinical Research 5: 37–43 (1979).

    CAS  Google Scholar 

  • Leroy, A.; Humbert, G. and Fillastre, J.P.; Pharmacokinetics of moxalactam in subjects with normal and impaired renal function. Antimicrobial Agents and Chemotherapy 19: 965–971 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Leroy, A.; Leguy, F.; Borsa, F.; Spencer, G.R.; Fillastre, J.P. and Humbert, G.: Pharmacokinetics of ceftazidime in normal and uremic subjects. Antimicrobial Agents and Chemotherapy 25: 638–642 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Livermore, D.M.; Williams, R.J. and Williams, J.D.: Comparison of the β-lactamase stability and the in-vitro activity of cefoperazone, cefotaxime, cefsulodin, ceftazidime, moxalactam and ceftriaxone against Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy 8: 323–331 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Lode, H.: Pharmacokinetics of new cephalosporin antibiotics: Cefotaxime, cefoperazone, moxalactam. International Medicine 2: 7–12 (1983).

    Google Scholar 

  • Lode, H.; Kemmerich, B.; Koeppe, P.; Belmega, D. and Jendroschek, H.: Comparative pharmacokinetics of cefoperazone and cefotaxime. Clinical Therapeutics 3 (Special Issue): 80–88 (1980).

    PubMed  CAS  Google Scholar 

  • Luderer, J.R.; Patel, I.H.; Durkin, J. and Schneck, D.W.: Age and ceftriaxone kinetics. Clinical Pharmacology and Therapeutics 35: 19–25 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Lüthy, R.; Blaser, J.; Bonetti, A.; Simmen, H.; Wise, R. and Siegenthaler, W.: Comparative multiple-dose pharmacokinetics of cefotaxime, moxalactam and ceftazidime. Antimicrobial Agents and Chemotherapy 20: 567–575 (1981).

    Article  PubMed  Google Scholar 

  • Lüthy, R.; Münch, R.; Blaser, J.; Bhend, H. and Siegenthaler, W.: Human pharmacology of cefotaxime (HR 756), a new cephalosporin. Antimicrobial Agents and Chemotherapy 16: 127–133 (1979).

    Article  PubMed  Google Scholar 

  • Lyon, J.A: Cefoperazone (Cefobid, Pfizer). Drug Intelligence and Clinical Pharmacy 17: 7–11 (1983).

    PubMed  CAS  Google Scholar 

  • McCormick, E.M.; Echols, R.M. and Rosano, T.G.: Liquid Chromatographic assay of ceftizoxime in sera of normal and uremic patients. Antimicrobial Agents and Chemotherapy 25: 336–338 (1984).

    Article  PubMed  CAS  Google Scholar 

  • McCracken, G.H. and Schaad, U.B.: Pharmacokinetics of moxalactam in neonates and young infants. Reviews of Infectious Diseases 4 (Suppl.): S595–S596 (1982).

    Article  PubMed  Google Scholar 

  • McCracken, G.H.; Threlkeld, N.E. and Thomas, M.L.: Pharmacokinetics of cefolaxime in new born infants. Antimicrobial Agents and Chemotherapy 21: 683–684 (1982).

    Article  PubMed  CAS  Google Scholar 

  • McMahon, F.G.: Disulfiram-like reaction to a cephalosporin. Journal of the American Medical Association 243: 2397 (1980).

    Article  PubMed  CAS  Google Scholar 

  • McNamara, P.J.; Gibaldi, M. and Stoeckel, K.: Volume of distribution terms for a drug (ceftriaxone) exhibiting concentration-dependent protein binding. I. Theoretical considerations. European Journal of Clinical Pharmacology 25: 399–405 (1983a).

    Article  PubMed  CAS  Google Scholar 

  • McNamara, P.J.; Gibaldi, M. and Stoeckel, K.: Volume of distribution terms for a drug (ceftriaxone) exhibiting concentration-dependent protein binding. II. Physiological significance. European Journal of Clinical Pharmacology 25: 407–412 (1983b).

    Article  PubMed  CAS  Google Scholar 

  • McNamara, P.J.; Stoeckel, K. and Ziegler, W.H.: Pharmacokinetics of ceftriaxone following intravenous administration of a 3g dose. European Journal of Clinical Pharmacology 22: 71–75 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Mandell, G.L. and Sande, M.A.: Antimicrobial agents: Penicillins and cephalosporins; in Gilman et al. (Eds) The Pharmacological Basis of Therapeutics, pp.1126–1161 (MacMillan Publishing Co, New York 1980).

    Google Scholar 

  • Marchou, B.; Tran Van Tho and Armengaud, M.: Diffusion of ceftriaxone (Ro 13-9904-001) in the cerebrospinal fluid. Chemotherapy 27 (Suppl. 1): 37–41 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Martin, E.; Koup, J.R. and Stoeckel, K.: Ceftriaxone pharmacokinetics in neonates and infants with meningitis. Journal of Pediatrics (In press, 1984).

  • Martini, A.; Chiara, A.; Mangili, G.; Burgio, R.; Careddu, P.; Rosaschino, F. and Scaglione, F.: Pharmacokinetics and clinical efficacy of cefoperazone in paediatrics. International Medicine 2: 13–14 (1983).

    Google Scholar 

  • Matzke, G.R. and Keane, W.F.: Cefsulodin pharmacokinetics in patients with various degrees of renal function. Antimicrobial Agents and Chemotherapy 23: 369–373 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Maudgal, D.P.; Maxwell. J.D.; Lees, L.J. and Wild, R.N.: Comparison of plasma and bile concentrations of amoxycillin and ceftriaxone (Rocephin) after bolus intravenous administration. British Journal of Clinical Pharmacology 13: 279P–280P (1982).

    Article  Google Scholar 

  • Medical Letter: New drugs for enteric Gram-negative bacillary meningitis in adults. Medical Letter 23: 73–74 (1981).

    Google Scholar 

  • Metzger, M.; Steffens, A.; Metz, B.; Daschner, F.; Kaiser, D. and Schlosser, V.: Serum- und Gewebespiegel von Cefsulodin. Der Krankenhausarzt 53: 536–541 (1981).

    Google Scholar 

  • Meyers, B.R.; Hirschman, S.Z.; Giron, J. and Srulevitch, E.S.: Pharmacokinetic studies of single and multiple doses of moxalactam (Moxam) in normal volunteers. Clinical Trials Journal 19: 63–73 (1982).

    Google Scholar 

  • Meyers, B.R.; Srulevitch, E.S.; Jacobson, J. and Hirschman, S.Z.: Crossover study of the pharmacokinetics of ceftriaxone administered intravenously or intramuscularly to healthy volunteers. Antimicrobial Agents and Chemotherapy 24: 812–814 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Modai, J.; Vittecoq, D.: Decazes, J.M.; Wolff, M. and Meulemans, A.: Penetration of ceftazidime into cerebrospinal fluid in patients with bacterial meningitis. Antimicrobial Agents and Chemotherapy 24: 126–128 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Moellering, R.C.: The third generation cephalosporins: Panacea or Pandora’s box. Pharmacotherapy 2: 169–171 (1982a).

    PubMed  Google Scholar 

  • Moellering, R.C.: Enterococcal infections in patients treated with moxalactam. Reviews of Infectious Diseases 4 (Suppl.): S708–S711 (1982b).

    Article  PubMed  Google Scholar 

  • Moreau, L.; Durand, H. and Biolet, P.: Cefotaxime concentrations in ascites. Journal of Antimicrobial Chemotherapy 6 (Suppl. A): 121–122 (1980).

    Article  PubMed  Google Scholar 

  • Muder, R.R.; Diven, W.F.; Yu, V.L. and Johnson, J.: Determination of cefoperazone concentration in serum and muscle tissue with a versatile high-pressure liquid Chromatographic method. Antimicrobial Agents and Chemotherapy 22: 1076–1078 (1982)

    Article  PubMed  CAS  Google Scholar 

  • Mueller, O.; Fabricius, K.; Krueger, E. and Rueckert, U.: Pharmacokinetics and clinical efficacy of moxalactam in biliary tract infections. Reviews of Infectious Diseases 4 (Suppl.): S688–S691 (1982).

    Article  PubMed  Google Scholar 

  • Myers, C.M. and Blumer, J.L.: Determination of ceftazidime in biological fluids by using high-pressure liquid chromatography. Antimicrobial Agents and Chemotherapy 24: 343–346 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Nahata, M.C.; Durrell, D.E. and Barson, W.J.: Moxalactam epimer kinetics in children. Clinical Pharmacology and Therapeutics 31: 528–532 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Nakamura, M.; Sugeno, K.; Konaka, R.; Yamada, H. and Yoshida, T.: Renal excretion of R- and S-epimers of moxalactam in dogs. Journal of Pharmaceutical Sciences 71: 1188–1189 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Nakashima, M.; Suzuki, K.; Hashimoto, H. and Nishijima, K.: Phase I study of ceftizoxime, a new cephalosporin. Single dosing study. Journal of Clinical Pharmacology 21: 388–395 (1981).

    PubMed  CAS  Google Scholar 

  • Nakashima, M.; Suzuki, K.; Hashimoto, H. and Nishijima, K.: Phase I study of ceftizoxime, a new cephalosporin. Repeated dosing study. Journal of Clinical Pharmacology 22: 28–31 (1982).

    PubMed  CAS  Google Scholar 

  • Neu, H.C.: A review and summary of the pharmacokinetics of cefoperazone: A new, extended-spectrum β-lactam antibiotic. Therapeutic Drug Monitoring 3: 121–128 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Neu, H.C.: Mechanisms of bacterial resistance to antimicrobial agents, with particular reference to cefotaxime and other β-lactam compounds. Reviews of Infectious Diseases 4 (Suppl.): S288–S299 (1982a).

    Article  PubMed  Google Scholar 

  • Neu, H.C.: The new beta-lactamase-stable cephalosporins. Annals of Internal Medicine 97: 408–419 (1982b).

    PubMed  CAS  Google Scholar 

  • Neu, H.C.: Ceftizoxime: A beta-lactamase-stable, broad-spectrum cephalosporin. Pharmacokinetics, adverse effects and clinical use. Pharmacotherapy 4: 47–60 (1984).

    PubMed  CAS  Google Scholar 

  • Neu, H.C.; Aswapokee, N.; Aswapokee, P. and Fu, K.P.: HR 756, a new cephalosporin active against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Antimicrobial Agents and Chemotherapy 15: 273–281 (1979a).

    Article  PubMed  CAS  Google Scholar 

  • Neu, H.C.; Aswapokee, P.; Fu, K.P.; Ho, I. and Matthijssen, C.: Cefotaxime kinetics after intravenous and intramuscular injection of single and multiple doses. Clinical Pharmacology and Therapeutics 27: 677–685 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Neu, H.C. and Fu, K.P.: In vitro antibacterial activity and β-lactamase stability of SCE-129, a new cephalosporin. Antimicrobial Agents and Chemotherapy 15: 646–650 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Neu, H.C.; Fu, K.P.; Aswapokee, N.; Aswapokee, P. and Kung, K.: Comparative activity and β-lactamase stability of cefoperazone, a piperazine cephalosporin. Antimicrobial Agents and Chemotherapy 16: 150–157 (1979b).

    Article  PubMed  CAS  Google Scholar 

  • Neu, H.C.; Meropol, N.J. and Fu, K.P.: Antibacterial activity of ceftriaxone (Ro 13-9904) a β-lactamase-stable cephalosporin. Antimicrobial Agents and Chemotherapy 19: 414–423 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Neu, H. and Prince, A.: Interaction between moxalactam and alcohol. Lancet 2: 1422 (1980).

    Article  Google Scholar 

  • Nielsen, O.S.; Toothaker, R.D.; Bundtzen, R.W.; Craig, W.A.; Welling, P.G. and Madsen, P.O.: Cefotaxime pharmacokinetics following a single intravenous dose to patients with varying renal function. Infection 8 (Suppl. 3): S305–S309 (1980).

    Article  Google Scholar 

  • Norrby, R.: A review of the penetration of antibiotics into CSF and its clinical significance. Scandinavian Journal of Infectious Diseases 14 (Suppl.): 296–309 (1978).

    PubMed  CAS  Google Scholar 

  • Notila, L. and Suttie, J.W.: Inhibition of vitamin K-dependent carboxylase in vitro by cefamandole and its structural analogs. Journal of Infectious Diseases 148: 571–578 (1983).

    Article  Google Scholar 

  • O’Callaghan, C.H.: Description and classification of the newer cephalosporins and their relationships with the established compounds. Journal of Antimicrobial Chemotherapy 5: 635–671 (1979).

    Article  PubMed  Google Scholar 

  • Ohkawa, M.; Okasho, A.; Motoi, I.; Tokunaga, S.; Shoda, R.; Kawaguchi, S.; Sawaki, M.; Shimamura, M.; Hirano, S.; Kuroda, K. and Awarazu, S.: Elimination kinetics of cefotaxime and desacetyl cefotaxime in patients with renal insufficiency and during hemodialysis. Chemotherapy 29: 4–12 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Øie, S. and Tozer, T.N.: Effect of altered plasma protein binding on apparent volume of distribution. Journal of Pharmaceutical Sciences 68: 1203–1205 (1979).

    Article  PubMed  Google Scholar 

  • Owen, A.W.M.C.; Manson, J. McK.; Yates, R.A.; Adshead, V.M.; Houghton, H.L. and Twccdlc, D.E.F: The pharmacokinetics of cefotetan excretion in the unobstructed biliary tree. Journal of Antimicrobial Chemotherapy 11 (Suppl. A): 217–221 (1983).

    Article  PubMed  Google Scholar 

  • Parsons, J.N.; Romano, J.M. and Levison, M.E.: Pharmacology of a new 1-oxa-β-lactam (LY 127935) in normal volunteers. Antimicrobial Agents and Chemotherapy 17: 226–228 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Patel, I.H.; Miller, K.; Weinfeld, R. and Spicehandler, J.: Multiple intravenous dose pharmacokinetics of ceftriaxone in man. Chemotherapy 27 (Suppl. 1): 47–56 (1981a).

    Article  PubMed  CAS  Google Scholar 

  • Patel, I.H.; Chen, S.; Parsonnet, M.; Hackman, M.R.; Brooks, M.A.; Konikoff, J. and Kaplan, S.A.: Pharmacokinetics of ceftriaxone in humans. Antimicrobial Agents and Chemotherapy 20: 634–641 (1981b).

    Article  PubMed  CAS  Google Scholar 

  • Patel, I.H.; Sugihara, J.G.; Weinfeld, R.E.; Wong, E.G.C.; Siemsen, A.W. and Berman, S.J.: Ceftriaxone pharmacokinetics in patients with various degrees of renal impairment. Antimicrobial Agents and Chemotherapy 25: 438–442 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Perea, E.J.; Nogales, M.C.; Aznar, J.; Martin, E. and Garcia-Iglesias, M.C.: Synergy between cefotaxime, cefsulodin, azlocillin, mezlocillin and aminoglycosides against carbenicillin-resistant or susceptible Pseudomonas aeruginosa; in Nelson and Grassi (Eds) Current Chemotherapy and Infectious Disease, Vol. 1, pp. 157–159 (American Society for Microbiology, Washington, DC 1980).

    Google Scholar 

  • Perfect, J.R. and Durack, D.T.: Pharmacokinetics of cefoperazone, moxalactam, cefotaxime, trimethoprim and sulphameth-oxazole in experimental meningitis. Journal of Antimicrobial Chemotherapy 8: 49–58 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Peterson, L.R.; Bean, B.; Fasching, C.E.; Korchik, W.P. and Gerding, D.N.: Pharmacokinetics, protein binding, and predicted extravascular distribution of moxalactam in normal and renal failure subjects. Antimicrobial Agents and Chemotherapy 20: 376–381 (1981).

    Article  Google Scholar 

  • Peterson, L.R.; Van Etta, L.V.; Fashing, C.E. and Gerding, D.N.: Effect of protein binding on simulated intravascular and extravascular kinetics of cefotaxime in an in vitro model. Antimicrobial Agents and Chemotherapy 25: 58–61 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Pickup, M.E.; Bird, H.A.; Lowe, J.R.; Lees, L. and Wright, V.: A pharmacokinetic and tolerance study of Ro 13-9904, a new cephalosporin antibiotic. British Journal of Clinical Pharmacology 12: 111–115 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Platt, R.: Adverse effects of third-generation cephalosporins. Journal of Antimicrobial Chemotherapy 10 (Suppl. C): 135–140 (1982).

    Article  PubMed  Google Scholar 

  • Plouffe, J.F.; Perkins, R.L.; Fass. R.J.; Prior, R.B.; Bernstein, B. and Ho, I.: Cefotaxime: Pharmacokinetics and in vitro antibacterial activity of serum and urine in normal volunteers. Chemotherapy 29: 73–79 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Pollock, A.A.; Tee, P.E.; Patel, I.H.; Spicehandler, J.; Simberkoff, M.S. and Rahal, J.J.: Pharmacokinetic characteristics of intravenous ceftriaxone in normal adults. Antimicrobial Agents and Chemotherapy 22: 816–823 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Portier, H.; Chalopin, J.M.; Freysz, M. and Tanter, Y.: Interaction between cephalosporins and alcohol. Lancet 2: 263 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Prince, A.S. and Neu, H.C.: Activities of new beta-lactam antibiotics against isolates of Pseudomonas aeruginosa from patients with cystic fibrosis. Antimicrobial Agents and Chemotherapy 20: 545–546 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Prinsloo, J.G.; Delport, S.D.; Moncrieff, J. and Paton, A.M.: Pharmacokinetics of ceftazidime in premature, newborn and young infants. South African Medical Journal 65: 809–811 (1984).

    PubMed  CAS  Google Scholar 

  • Quintiliani, R. and Nightingale, C.H.: Comparative pharmacokinetics of ceftizoxime and other third generation cephalosporins in humans. Journal of Antimicrobial Chemotherapy 10 (Suppl. C): 99–104 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Quintiliani, R.; Nightingale, C.H. and Tilton, R.: Conparative pharmacokinetics of cefotaxime and ceftizoxime and the role of desacetylcefotaxime in the antibacterial activity of cefotaxime. Diagnostic Microbiology and Infectious Disease 2 (Suppl.): 63S–70S (1984).

    PubMed  CAS  Google Scholar 

  • Rahal, J.J. and Simberkoff, M.S.: Host defense and antimicrobial therapy in adult Gram-negative bacillary meningitis. Annals of Internal Medicine 96: 468–474 (1982).

    PubMed  CAS  Google Scholar 

  • Reed, M.D.; Rekate, H.L.; Aronoff, S.C.; Myers, C.M. and Blumer, J.L.: Single-dose plasma and cerebrospinal fluid pharmacokinetics of ceftriaxone in infants and children. Clinical Pharmacy 2: 558–563 (1983).

    PubMed  CAS  Google Scholar 

  • Reeves, D.S. and Davies, A.: Antabuse effect with cephalosporins. Lancet 2: 540 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Reeves, D.S., White, L.O.; Hold, H.A.; Bahari, D.; Bywater, M.J. and Bax, R.P.: Human metabolism of cefotaxime. Journal of Antimicrobial Chemotherapy 6 (Suppl. A): 93–101 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Richards, D.M. and Heel, R.C.: Ceftizoxime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 29: 281–329 (1985).

    Article  PubMed  CAS  Google Scholar 

  • Richards, D.M.; Heel, R.C.; Brogden, R.N.; Speight, T.M. and Avery, G.S.: Ceftriaxone. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs 27: 469–527 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Richardson, B.L.; Woodford, J.D. and Andrews, G.D.: The pharmacy of ceftazidime. Journal of Antimicrobial Chemotherapy 8 (Suppl. B): 233–236 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Richmond, M.H.: The (β-lactamase stability of a novel (β-lactam antibiotic containing a 7 α-methoxyoxacephem nucleus. Journal of Antimicrobial Chemotherapy 6: 445–453 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Rolfe, R.D. and Finegold, S.M.: Comparative in vitro activity of new beta-lactam antibiotics against anaerobic bacteria. Antimicrobial Agents and Chemotherapy 20: 600–609 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Rolfe, R.D. and Finegold, S.M.: Comparative in vitro activity of ceftriaxone against anaerobic bacteria. Antimicrobial Agents and Chemotherapy 22: 338–341 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Ruf, K.B.: Monaspor® (cefsulodin), clinical and pharmacological profile of a unique antibiotic, highly effective against Pseudomonas aeruginosa; in A Comprehensive Guide to the Therapeutic Use of Cefsulodin, pp.50–81 (S. Karger, Basel 1980).

    Google Scholar 

  • Sakamoto, H.; Murakawa, T.; Hirose, T. and Nishida, M.: Effect of ceftizoxime, a new cephalosporin antibiotic, on binding of bilirubin to human serum albumin. Chemotherapy 29: 244–248 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Sakata, Y.; Boccazzi, A. and McCracken, G.H.: Pharmacokinetics and bacteriological effect of ceftazidime in experimental Streptococcus pneuomoniae, Haetnophilus influenzae, and Escherichia coli meningitis. Antimicrobial Agents and Chemotherapy 23: 213–217 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Salzer, W.; Pegram, Jr P.S. and McCall, C.E.: Clinical evaluation of moxalactam: Evidence of decreased efficacy in Gram-positive aerobic infections. Antimicrobial Agents and Chemotherapy 23: 565–570 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Sanders, C.C.: Inducible (β-lactamases and non-hydrolytic resistance mechanisms. Journal of Antimicrobial Chemotherapy 13: 1–3 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Schaad, U.B. and McCracken, G.H.: Pharmacologic basis for antimicrobial therapy of neonatal meningitis. Helvetica Paediatrica Acta 36: 19–30 (1981).

    PubMed  CAS  Google Scholar 

  • Schaad, U.B.; McCracken, G.H.; Loock, C.A. and Thomas, M.L.: Pharmacokinetics and bacteriologic efficacy of moxalactam, cefotaxime, cefoperazone, and Rocephin in experimental bacterial meningitis. Journal of Infectious Diseases 143: 156–163 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Scheid, W.; Brodeur, J.P.; Sande, M.A. and Alliegro, G.M.: Comparison of cefoperazone with penicillin, ampicillin, gentamicin, and chloramphenicol in the therapy of experimental meningitis. Antimicrobial Agents and Chemotherapy 22: 652–656 (1982).

    Article  Google Scholar 

  • Scheid, W.M.; Spyker, D.A.; Donowitz, G.R.; Bolton, W.K. and Sande, M.A.: Moxalactam and cefazolin: Comparative pharmacokinetics in normal subjects. Antimicrobial Agents and Chemotherapy 19: 613–619 (1981).

    Article  Google Scholar 

  • Schoeller, J.P.; Fillastre, J.P.; Humbert, G. and Lecaillon, J.B.: Pharmacokinetics of cefsulodin in patients with renal insufficiency; in Periti and Grassi (Eds) Current Chemotherapy and Immunotherapy, Vol. 1, pp.526–527 (American Society for Microbiology, Washington, DC 1982).

    Google Scholar 

  • Scully, B.E. and Neu, H.C.: The use of ceftizoxime in the treatment of critically ill patients infected with multiply antibiotic-resistant bacteria. Journal of Antimicrobial Therapy 10 (Suppl. C): 141–150 (1982).

    Article  Google Scholar 

  • Shah, P.M.; Knobloch, M.; Haag, R. and Kühnle, H.F.: Pharmacokinetics of ceftizoxime in patients undergoing hemodialysis. Methods and Findings in Experimental Clinical Pharmacology 4: 185–188 (1982).

    CAS  Google Scholar 

  • Shannon, K.; King, A.; Warren, C. and Phillips, I.: In vitro antibacterial activity and susceptibility of the cephalosporin Ro 13-9904 to beta-lactamases. Antimicrobial Agents and Chemotherapy 18: 292–298 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Shearer, M.J.; Rahim, S.; Barkham, P. and Stimmler, L.: Plasma vitamin Kl in mothers and their newborn babies. Lancet 2: 460–463 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Shimizu, K.: Cefoperazone: Absorption, excretion, distribution, and metabolism. Clinical Therapeutics 3 (Special Issue): 60–79 (1980).

    PubMed  CAS  Google Scholar 

  • Shyu, W.C.; Nightingale, C.H.; Quintiliani, R.; Rose, D.; Rosson, R.; Owens, N. and Helmink, R.: Biliary excretion of cefotaxime. Current Therapeutic Research 35: 727–734 (1984).

    Google Scholar 

  • Singlas, E.; Boutron, H.F.; Merdjan, H.; Brocard, J.F.; Pocheville, M. and Fries, D.: Moxalactam kinetics during chronic ambulatory peritoneal dialysis. Clinical Pharmacology and Therapeutics 34: 403–407 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Smith, C.R. and Lipsky, J.J.: Hypoprothrombinemia and platelet dysfunction caused by cephalosporin and oxalactam antibiotics. Journal of Antimicrobial Chemotherapy 11: 496–499 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Sommers, D.K.; Walters, L.; Van Wyk, M.; Harding, S.M.; Paton, A. and Ayrton, J.: Pharmacokinetics of ceftazidime in male and female volunteers. Antimicrobial Agents and Chemotherapy 23: 892–896 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Soussy, C.J.; Deforges, L.P.; Le Van Thoi, J.; Feghali, W. and Duval, J.R.: Cefotaxime concentration in the bile and wall of the gallbladder. Journal of Antimicrobial Chemotherapy 6 (Suppl. A): 125–130 (1980).

    Article  PubMed  Google Scholar 

  • Srinivasan, S.; Francke, E.L.; Appel, G.B.; Salzman, M. and Neu, H.C.: The pharmacokinetics of moxalactam, cefotaxime and cefoperazone in patients with renal insufficiency and undergoing hemodialysis. Abstract No. 246, 20th ICAAC (Excerpta Medita, Amsterdam 1980).

  • Srinivasan, S.; Fu, K.P. and Neu, H.C.: Pharmacokinetics of moxalactam and cefazolin compared in normal volunteers. Antimicrobial Agents and Chemotherapy 19: 302–305 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Steele, R.W.; Eyre, L.B.; Bradsher, R.W.; Weinfeld, R.E.; Patel, I.H. and Spicehandler, J.: Pharmacokinetics of ceftriaxone in pediatric patients with meningitis. Antimicrobial Agents and Chemotherapy 23: 191–194 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Stoeckel, K.: Pharmacokinetics of Rocephin®, a highly active new cephalosporin with an exceptionally long biological half-life. Chemotherapy 27 (Suppl. 1): 42–46 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Stoeckel, K.: Pharmacokinetik parenteraler Cephalosporine in Prüfphase III (Cefmenoxim, Ceftazidim, Ceftizoxim, Cefotetan, Cefonicid, Ceforanid, Ceftriaxon). Fortschritte der Anti-mikrobiellen und Antineoplastischen Chemotherapie 1: 105–113 (1982).

    CAS  Google Scholar 

  • Stoeckel, K.: Pharmacokinetics of ceftriaxone, a long-acting broad-spectrum cephalosporin; in Progress in Therapy of Bacterial Infections. A new Cephalosporin: Ceftriaxone. Proceedings 1983, APCS No. 19 pp.5–20 (Excerpta Medica, Amsterdam 1983).

    Google Scholar 

  • Stoeckel, K. and Koup, J.R.: Pharmacokinetics of ceftriaxone in patients with renal and liver insufficiency and correlations with a physiologic non-linear protein binding model. American Journal of Medicine (In press, 1984).

  • Stoeckel, K.; McNamara, P.J.; Brandt, R.; Plozza-Nottebrock, H. and Ziegler, W.H.: Effects of concentration-dependent plasma protein binding on ceftriaxone kinetics. Clinical Pharmacology and Therapeutics 29: 650–657 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Stoeckel, K.; McNamara, P.J.; Hoppe-Seyler, G.; Blumberg, A. and Keller, E.: Single-dose ceftriaxone kinetics in functionally anephric patients. Clinical Pharmacology and Therapeutics 33: 633–641 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Stoeckel, K.; Trueb, V. and Tuerk, H.: Single-dose pharmacokinetics of ceftriaxone in liver disease patients. Abstract 243, in 3rd Mediterranean Congress of Chemotherapy, Dubrovnik, 21–24 September 1982.

    Google Scholar 

  • Suzuki, A.; Noda, K. and Noguchi, H.: High-performance liquid Chromatographic determination of ceftizoxime, a new cephalosporin antibiotic, in rat serum, bile and urine. Journal of Chromatography (Biomedical Applications) 182: 448–453 (1980).

    Article  CAS  Google Scholar 

  • Swanson, D.J.; Reitberg, D.P.; Smith, I.L.; Wels, P.B. and Schentag, J.J.: Steady-state moxalactam pharmacokinetics in patients: Noncompartmental versus two-compartmental analysis. Journal of Pharmacokinetics and Biopharmaceutics 11: 337–353 (1983).

    Article  PubMed  Google Scholar 

  • Sykes, R.B.: The classification and terminology of enzymes that hydrolyze β-lactam antibiotics. Journal of Infectious Diseases 145: 762–765 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Sykes, R.B. and Matthew, M.: The β-lactamases of Gram-negative bacteria and their role in resistance to β-lactam antibiotics. Journal of Antimicrobial Chemotherapy 2: 115–157 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Ti, T.-Y.: Fortin, L.; Kreeft, J.H.; East, D.S.; Ogilvie, R.I. and Somerville, P.J.: Kinetic disposition of intravenous ceftriaxone in normal subjects and patients with renal failure on hemodialysis or peritoneal dialysis. Antimicrobial Agents and Chemotherapy 25: 83–87 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Tjandramaga, T.B.; van Hecken, A.; Mullie, A.; Verbesselt, R.; de Schepper, P.J. and Verbist, L.: Comparative pharmacokinetics of ceftazidime and moxalactam. Antimicrobial Agents and Chemotherapy 22: 237–241 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Tomasz, A.: From penicillin-binding proteins to the lysis and death. Reviews of Infectious Diseases 1: 434–467 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Tozer, T.N.: Concepts basic to pharmacokinetics. Pharmacology and Therapeutics 12: 109–131 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Trautmann, K.H. and Haefelfinger, P.: Determination of Ro 13-9904 in plasma, urine and bile by means of reversed phase chromatography. Journal of High Resolution Chromatography 4: 54–59 (1981).

    Article  CAS  Google Scholar 

  • Turnidge, J.D. and Craig, W.A.: β-Lactam pharmacology in liver disease. Journal of Antimicrobial Chemotherapy 11: 499–501 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Uri, J.V. and Parks, D.B.: Disulfiram-like reaction to certain cephalosporins. Therapeutic Drug Monitoring 5: 219–224 (1983).

    Article  PubMed  CAS  Google Scholar 

  • van der Anwera, P. and Schuyteneer, F.: In-vitro susceptibility of Pseudomonas aeruginosa to old and new β-lactam antibiotics and aminoglycosides. Journal of Antimicrobial Chemotherapy 11: 511–515 (1983).

    Article  Google Scholar 

  • Vartivarian, S.; Harakeh, H.; Kantarjian, H. and Uwaydah, M.: Biliary concentrations of moxalactam. Infection 12: 104 (1984).

    Article  Google Scholar 

  • Vischer, W.; Gerardin, A.; Humbert, G.; Lecaillon, J.B.; Schoeller, J.P. and Theobald, W.; Pharmacokinetics of cefsulodin after single and chronic intravenous administration to humans; in Periti and Grassi (Eds) Current Chemotherapy and Immunotherapy, Vol. 1, pp.S24–525 (American Society for Microbiology, Washington DC 1982).

    Google Scholar 

  • Walker, S.H. and Touradji, N.: Penetration of moxalactam into the cerebrospinal fluid. Drugs Under Experimental and Clinical Research 9: 423–425 (1983).

    Google Scholar 

  • Ward, J.I. and Moellering Jr, R.C.: Susceptibility of pneumococci to 14 beta-lactam agents: Comparison of strains resistant, intermediate-resistant, and susceptible to penicillin. Antimicrobial Agents and Chemotherapy 20: 204–207 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Weinstein, A.J.; The cephalosporins: Activity and clinical use. Drugs 20: 137–154 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Weitekamp, R.M. and Aber, R.C.: Prolonged bleeding times and bleeding diathesis associated with moxalactam administration. Journal of the American Medical Association 249: 69–71 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Welage, L.S.; Schultz, R.W. and Schentag, J.J.: Pharmacokinetics of ceftazidime in patients with renal insufficiency. Antimicrobial Agents and Chemotherapy 25: 201–204 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Whelton, A.: Antibiotic pharmacokinetics and clinical application in renal insufficiency. Medica! Clinics of North America 66: 267–281 (1982).

    CAS  Google Scholar 

  • Wise, R.: Penicillins and cephalosporins: Antimicrobial and pharmacological properties. Lancet 2: 140–143 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Wise, R. and Wright, N.: Cefotaxime metabolism and renal function. Lancet 1: 1106–1107 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Wise, R.; Andrews, J.M. and Haucox, J.: In vitro activity of cefotetan, a new cephamycin derivative, compared with that of other β-lactam compounds. Antimicrobial Agents and Chemotherapy 21: 486–491 (1981d).

    Article  Google Scholar 

  • Wise, R.; Armstrong, G.C.; Brown, R.M. and Andrews, J.M.: The pharmacokinetics and tissue penetration of ceftazidime and cefamandole in healthy volunteers. Journal of Antimicrobial Chemotherapy 8 (Suppl. B): 277–282 (1981a).

    Article  PubMed  CAS  Google Scholar 

  • Wise, R.; Baker, S. and Livingston, R.: Comparison of cefotaxime and moxalactam pharmacokinetics and tissue levels. Antimicrobial Agents and Chemotherapy 18: 369–371 (1980b).

    Article  PubMed  CAS  Google Scholar 

  • Wise, R.; Wills, P.J.; Andrews, J.M. and Bedford, K.A.: Activity of the cefotaxime (HR 756) desacetyl metabolite compared with those of cefotaxime and other cephalosporins. Antimicrobial Agents and Chemotherapy 17: 84–86 (1980a).

    Article  PubMed  CAS  Google Scholar 

  • Wise, R.; Wills, P.J. and Bedford, K.A.: Epimers of moxalactam: In vitro comparison of activity and stability. Antimicrobial Agents and Chemotherapy 20: 30–32 (1981b).

    Article  PubMed  CAS  Google Scholar 

  • Wise, R.; Wright, N. and Wills, P.J.: Pharmacology of cefotaxime and its desacetyl metabolite in renal and hepatic disease. Antimicrobial Agents and Chemotherapy 19: 526–531 (1981c).

    Article  PubMed  CAS  Google Scholar 

  • Wittmann, D.H.; Schassan, H.-H.; Kohler, F. and Seibert, W.: Pharmacokinetic studies of ceftazidime in serum, bone, bile, tissue fluid and peritoneal fluid. Journal of Antimicrobial Chemotherapy 8 (Suppl. B): 293–297 (1981).

    PubMed  CAS  Google Scholar 

  • Wold. J. and Buening, M.: Alcohol-moxalactam interactions in vivo; in Symposium on the New Generation of Beta-lactam Antibiotics, London (1981).

  • Wright, N. and Wise. R.: Elimination characteristics and dosage recommendations for cefotaxime in renal failure. Abstract No. 235, 20th ICAAC (Excerpta Medica, Amsterdam 1980).

    Google Scholar 

  • Wright, N.; Wise. R. and Hegarty, T.: Cefotetan elimination in patients with varying degrees of renal dysfunction. Journal of Antimicrobial Chemotherapy 11 (Suppl. A): 213–216 (1983).

    Article  PubMed  Google Scholar 

  • Yamada, H.; Ichihashi, T.; Hirano, K. and Kinoshita, H.: Plasma protein binding and urinary excretion of R- and S-epimers of an arylmalonylamino l-oxacephem. I: In humans. Journal of Pharmaceutical Sciences 70: 112–113 (1981a).

    Article  PubMed  CAS  Google Scholar 

  • Yamada. H.; Ichihashi, T.; Hirano, K. and Kinoshita, H.: Plasma protein binding and urinary excretion of R- and S-epimers of an arylmalonylamino l-oxacephem, II: In rats. Journal of Pharmaceutical Sciences 70: 113–114 (1981b).

    Article  PubMed  CAS  Google Scholar 

  • Yates, R.A.; Adam, H.K.; Donnelly, R.J.; Houghton, H.L.; Charlesworth, E.A. and Laws, E.A.: Pharmacokinetics and tolerance of single intravenous doses of cefotetan disodium in male Caucasian volunteers. Journal of Antimicrobial Chemotherapy 11 (Suppl. A): 185–191 (1983a).

    Article  PubMed  CAS  Google Scholar 

  • Yates, R.A.; Cockshott, I.D.; Houghton, H.L.; Wardleworth, A.; Adam, H. and Donnelly, R.J.: Pharmacokinetics and tolerance of single intramuscular doses of cefotetan in normal Caucasian volunteers. Journal of Antimicrobial Chemotherapy 11 (Suppl. A): 207–212 (1983b).

    Article  PubMed  CAS  Google Scholar 

  • Yoshikawa, T.T.; Maitra, S.K.; Schotz, M.C. and Guze, L.B.: High-pressure liquid chromatography for quantitation of antimicrobial agents. Reviews of Infectious Diseases 2: 169–181 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Yu. V.L.: Enterococcal superinfection and colonization after therapy with moxalactam, a new broad-spectrum antibiotic. Annals of Internal Medicine 94: 784–787 (1981).

    PubMed  CAS  Google Scholar 

  • Yu, V.L.; Vickers, R.M. and Zuravleff, J.J.: Comparative susceptibilities of Pseudomonas aeruginosa to l-oxacephalosporin (LY 127935) and eight other antipseudomonal antimicrobial agents (old and new). Antimicrobal Agents and Chemotherapy 17: 96–98 (1980).

    Article  CAS  Google Scholar 

  • Zak, O.; Konopka, E.A.; Tosch, W.; Ahrens, T.; Zimmermann, W. and Kradolfer, F.: Experimental evaluation of CGP7174/E (SCE 129), a new injectable cephalosporin antibiotic active against Pseudomonas aeruginosa. Drugs under Experimental and Clinical Research 5: 45–59 (1979).

    CAS  Google Scholar 

  • Ziemniak, J.A.; Chiarmonte, D.A.; Miner, D.J. and Schentag, J.J.: HPLC determination of D and L moxalactam in human serum and urine. Journal of Pharmaceutical Sciences 71: 399–402 (1982).

    Article  PubMed  CAS  Google Scholar 

Monographs Cefsulodin

  • Sabath, L.D. (Ed.): Pseudomonas aeruginosa, the Organism, Diseases it Causes, and their Treatment (Hans Huber, Bern 1980). A Comprehensive Guide to the Therapeutic Use of Cefsulodin, (Karger, Basel 1980).

Cefotaxime

  • Geddes, A.M.; Acar, J.F. and Knothe, H. (Eds): Cefotaxime: A New Cephalosporin Antibiotic. Journal of Antimicrobial Chemotherapy, Vol. 4, Suppl. A (1980).

  • Cherubin, C.E.: Neu, H.C. and Turck. M. (Eds): Current Status of Cefotaxime Sodium: A New Cephalosporin. Reviews of Infectious Diseases. Vol. 4, Suppl. A (1982).

Cefoperazone

  • First International Symposium on Cefoperazone Sodium, Clinical Therapeutics, Vol. 3. Special Issue (1980). Lang. S.D.R. (Ed.): Fifth International Symposium on Cefoperazone Sodium. Drugs, Vol. 22, Suppl. 1 (1981). Sixth International Cefoperazone Symposium (Excerpta Medica, Amsterdam 1983).

  • Klein, J.O. and Neu, H.C. (Eds): Empiric Therapy for Bacterial Infections: Evaluation of Cefoperazone. Reviews of Infectious Diseases, Vol. 5, Suppl. 1 (1983).

Latamoxef

  • Moellering, R.C. and Young, L.S. (Eds): Moxalactam International Symposium. Reviews of Infectious Diseases, Vol. 4, Suppl. (1982).

Ceftriaxone

  • Reports on Ceftriaxone (Rocephin®), Chemotherapy. Vol. 27, Suppl. 1 (1981).

  • Dettli, L.; Lode, H.; Naumann, P.; Spitzy, K.H. and Schönfeld, H. (Eds): Ceftriaxon (Rocephin®) ein Neues Parenterales Cephalosporin. Editiones “Roche” (1981).

  • Progress in Therapy of Bacterial Infections. A New Cephalosporin: Ceftriaxone. Proceedings 1983, APCS No. 19 (Excerpta Medica. Amsterdam 1983).

Ceftazidime

  • Williams, J.D. and Casewell, M.W. (Eds): Ceftazidime. Journal of Antimicrobial Chemotherapy, Vol. 8, Suppl. B (1981). O’Grady. F.; Marget. W. and Harper, P.B. (Eds): Ceftazidime. Infection. Vol. 11. Suppl. 1 (1983).

Ceftizoxime

  • Neu, H.C.; Turck. M. and Phillips, I. (Eds): Ceftizoxime, A BroadSpeclrum β-Lactamase Stable Cephalosporin. Journal of Antimicrobial Chemotherapy. Vol. 10, Suppl. C (1982).

Cefotetan

  • Phillips. I.; Wise. R. and Leigh, DA. (Eds): Cefotetan: A New Cephamycin. I. Journal of Antimicrobial Chemotherapy, Vol. 11, Suppl. A (1983).

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Authors and Affiliations

  1. Outpatient Clinic and Division of Infectious Diseases, Department of Medicine, University of Geneva, Geneva, Switzerland

    Luc P. Balant, P. Dayer & R. Auckenthaler

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  1. Luc P. Balant
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  2. P. Dayer
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  3. R. Auckenthaler
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Balant, L.P., Dayer, P. & Auckenthaler, R. Clinical Pharmacokinetics of the Third Generation Cephalosporins. Clin Pharmacokinet 10, 101–143 (1985). https://doi.org/10.2165/00003088-198510020-00001

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  • DOI: https://doi.org/10.2165/00003088-198510020-00001

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