Skip to main content
Log in

Alcohol Use Disorders in Adolescents

Epidemiology, Diagnosis, Psychosocial Interventions, and Pharmacological Treatment

  • Therapy In Practice
  • Published:
Pediatric Drugs Aims and scope Submit manuscript

Abstract

Alcohol (ethanol) abuse and dependence are the most common substance use disorders among adolescents. Binge drinking occurs in up to one-third of adolescents, and alcohol use disorders occur in about 6% of this age group. Adolescents with alcohol use disorders also typically have problems with other substances and comorbid mental disorders. Validated measures are available for the clinical detection and diagnosis of adolescent alcohol use disorders and related problems. Psychosocial interventions promoting abstinence are the most common treatments for alcohol use disorders, with empirical support particularly strong for family-based approaches. Pharmacological interventions may diminish the effects of alcohol withdrawal, prevent a return to alcohol consumption, or treat comorbid mental disorders. In this population, pharmacological interventions require further investigation and, where indicated, are generally considered to be supplementary to psychosocial approaches.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Table I
Table II

Similar content being viewed by others

References

  1. Survey Research Center, Institute for Social Research, University of Michigan. Monitoring the future [online]. Available from URL: http://www.isr.umich.edu/src/mtf [Accessed 2002 May 22]

  2. Johnson LD, O’Malley PM, Bachman JG. Monitoring the future national survey results on drug use, 1975–2000. Vol. I, secondary school students. Bethesda (MD): National Institute on Drug Abuse, 2001. Report no: NIH 01-4924

    Google Scholar 

  3. Plant M, Miller P. Young people and alcohol: an international insight. Alcohol Alcohol 2001; 36(6): 513–5

    PubMed  CAS  Google Scholar 

  4. Cohen P, Cohen J, Kasen S, et al. An epidemiological study of disorders in late childhood and adolescence (I): age- and gender-specific prevalence. J Child Psychol Psychiatry 1993; 34: 851–67

    Article  PubMed  CAS  Google Scholar 

  5. Rohde P, Lewinsohn PM, Seeley JR. Psychiatric comorbidity with problematic alcohol use in high school students. J Am Acad Child Adolesc Psychiatry 1996; 35: 101–9

    Article  PubMed  CAS  Google Scholar 

  6. Bukstein OG. Summary of the practice parameters for the assessment and treatment of children and adolescents with substance use disorders. J Am Acad Child Adolesc Psychiatry 1997; 36: 122–6

    Article  Google Scholar 

  7. Clark DB, Kirisci L, Moss HB. Early adolescent gateway drug use in sons of fathers with substance use disorders. Addict Behav 1998; 23: 561–6

    Article  PubMed  CAS  Google Scholar 

  8. Clark DB, Parker AM, Lynch KG. Psychopathology, substance use and substance related problems during early adolescence: a survival analysis. J Child Clin Psychol 1999; 28: 333–41

    Article  CAS  Google Scholar 

  9. Clark DB, Vanyukov M, Cornelius J. Childhood antisocial behavior and adolescent alcohol use disorders. Alcohol Res Health. In press

  10. Clark DB, Winters KC. Measuring risks and outcomes in substance use disorders prevention research. J Consult Clin Psychol. In press

  11. Hill KG, White HR, Chung I-J, et al. Early adult outcomes of adolescent binge drinking: person- and variable-centered analyses of binge drinking trajectories. Alcohol Clin Exper Res 2000; 24(6): 892–901

    Article  CAS  Google Scholar 

  12. Martin CS, Kaczynski NA, Maisto SA, et al. Patterns of DSM-IV alcohol abuse and dependence symptoms in adolescent drinkers. J Stud Alcohol 1995; 56(6): 672–80

    PubMed  CAS  Google Scholar 

  13. Langenbucher J, Martin C, Labouvie E, et al. Toward the DSM-V: a withdrawal-gate model of alcohol abuse and dependence. J Consult Clin Psychol 2000; 68: 799–809

    Article  PubMed  CAS  Google Scholar 

  14. Clark DB, Kirisci L, Tarter RE. Adolescent vs adult onset and the development of substance use disorders in males. Drug Alcohol Depend 1998; 49: 115–21

    Article  PubMed  CAS  Google Scholar 

  15. Deas D, Riggs P, Langenbucher J, et al. Adolescents are not adults: developmental considerations in alcohol users. Alcohol Clin Exper Res 2000; 24(2): 232–7

    Article  CAS  Google Scholar 

  16. Clark DB, Neighbors BD, Lesnick LA, et al. Family functioning and adolescent alcohol use disorders. J Family Psychol 1998; 12: 81–92

    Article  Google Scholar 

  17. Clark DB, Kirisci L. PTSD, depression, alcohol use disorders, and quality of life in adolescents. Anxiety 1996; 2: 226–33

    Article  PubMed  CAS  Google Scholar 

  18. Moss HB, Kirisci L, Gordon HW, et al. A neuropsychologic profile of adolescent alcoholics. Alcohol Clin Exper Res 1994; 18: 159–63

    Article  CAS  Google Scholar 

  19. Tapert SF, Brown SA. Substance dependence, family history of alcohol dependence, and neuropsychological functioning in adolescence. Addiction 2000; 95: 1043–53

    Article  PubMed  CAS  Google Scholar 

  20. Brown SA, Tapert SF, Granholm E, et al. Neurocognitive functioning of adolescents: effects of protracted alcohol use. Alcohol Clin Exper Res 2000; 24: 164–71

    Article  CAS  Google Scholar 

  21. Tapert SF, Brown SA. Neuropsychological correlates of adolescent substance abuse: four-year outcomes. J Int Neuropsychol Soc 1999; 5: 481–93

    Article  PubMed  CAS  Google Scholar 

  22. De Bellis MD, Clark DB, Beers SR, et al. Hippocampal volume in adolescent onset alcohol use disorders. Am J Psychiatry 2000; 157: 737–44

    Article  PubMed  Google Scholar 

  23. Martin CS, Arria AM, Mezzich AC, et al. Patterns of polydrug use in adolescent alcohol abusers. Am J Drug Alcohol Abuse 1993; 19: 511–21

    Article  PubMed  CAS  Google Scholar 

  24. Cornelius JR, Lynch KG, Martin CS, et al. Clinical correlates of heavy tobacco use among adolescents. Addict Behav 2001; 26: 273–7

    Article  PubMed  CAS  Google Scholar 

  25. Martin CS, Kaczynski NA, Maisto SA, et al. Polydrug use in adolescent drinkers with and without DSM-IV alcohol abuse and dependence. Alcohol Clin Exper Res 1996; 20(6): 1099–108

    Article  CAS  Google Scholar 

  26. Clark DB, Pollock NA, Bromberger JT, et al. Gender and comorbid psychopathology in adolescents with alcohol use disorders. J Am Acad Child Adolesc Psychiatry 1997; 36: 1195–203

    Article  PubMed  CAS  Google Scholar 

  27. Crowley TJ, Macdonald MJ, Whitmore EA, et al. Cannabis dependence, withdrawal, and reinforcing effects among adolescents with conduct symptoms and substance use disorders. Drug Alcohol Depend 1998; 50: 27–37

    Article  PubMed  CAS  Google Scholar 

  28. Fergusson DM, Horwood LJ. Does cannabis use encourage other forms of illicit drug use. Addiction 2000; 95(4): 505–20

    Article  PubMed  CAS  Google Scholar 

  29. American Psychiatric Association. The diagnostic and statistical manual (DSM-IV). 4th ed. Washington, DC: American Psychiatric Association, 1994

    Google Scholar 

  30. Clark DB, Bukstein OG. Psychopathology in adolescent alcohol abuse and dependence. Alcohol Health Res World 1998; 22: 117–26

    PubMed  CAS  Google Scholar 

  31. Clark DB, Neighbors B. Adolescent substance abuse and internalizing disorders. Child Adolesc Psychiatr Clin North Am 1996; 5: 45–57

    Google Scholar 

  32. Clark DB, Scheid J. Comorbid mental disorders in adolescents with substance use disorders. In: Hubbard JR, Martin PR, editors. Substance abuse in the mentally and physically disabled. New York: Marcel Dekker, 2001: 133–67

    Google Scholar 

  33. Clark DB. Psychiatric assessment. In: Ott PJ, Tarter RE, Ammerman AT, editors. Sourcebook on substance abuse: etiology, methodology, and intervention. New York: Allyn & Bacon, 1999

    Google Scholar 

  34. Cornelius JR, Maisto SA, Pollock NK, et al. Rapid relapse generally follows treatment for substance use disorders among adolescents. Addict Behav. In press

  35. Aarons GA, Brown SA, Coe MT, et al. Adolescent alcohol and drug abuse and health. J Adolesc Health 1997; 24: 412–21

    Article  Google Scholar 

  36. Hansell S, White HR, Vali FM. Specific alcoholic beverages and physical and mental health among adolescents. J Stud Alcohol 1999; 60: 209–18

    PubMed  CAS  Google Scholar 

  37. Clark DB, Lynch KG, Donovan JD, et al. Health problems in adolescents with alcohol use disorders: self-report, liver injury and physical examination findings. Alcohol Clin Exper Res 2001; 25: 1350–9

    Article  CAS  Google Scholar 

  38. World Health Organization. International classification of diseases and related health problems. 10th rev. ed. Geneva: World Health Organization, 1993

    Google Scholar 

  39. Pollock NK, Martin CS, Langenbucher JW. Diagnostic concordance of DSM-III, DSM-III-R, DSM-IV and ICD-10 alcohol diagnoses in adolescents. J Stud Alcohol 2000; 61(3): 439–46

    PubMed  CAS  Google Scholar 

  40. Chung T, Martin CS, Winters KC, et al. Assessment of alcohol tolerance in adolescents. J Stud Alcohol 2001; 62: 687–95

    PubMed  CAS  Google Scholar 

  41. Pollock NK, Martin CS. Diagnostic orphans: adolescents with alcohol symptomatology who do not qualify for DSM-IV abuse or dependence diagnoses. Am J Psychiatry 1999; 156(6): 897–901

    PubMed  CAS  Google Scholar 

  42. Martin CS, Winters KC. Diagnosis and assessment of alcohol use disorders among adolescents. Alcohol Health Res World 1998; 22: 95–105

    PubMed  CAS  Google Scholar 

  43. Chung T, Colby SM, Barnett NP, et al. Screening adolescents for problem drinking: performance of brief screens against DSM-IV alcohol diagnoses. J Stud Alcohol 2000; 61(4): 579–87

    PubMed  CAS  Google Scholar 

  44. Rounsaville BJ, Poling J. Outcome measures for substance use disorders. American Psychiatric Association Task Force on Outcomes. In: The APA Handbook of Psychiatric Measures and Outcomes. Washington, DC: American Psychiatric Press, 2000: 457–84

    Google Scholar 

  45. National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health. AUDIT [online]. Available from URL: http://www.niaaa.nih.gov [Accessed 2002 May 22]

  46. Clark DB, Bukstein OG, Smith MG, et al. Identifying anxiety disorders in adolescents hospitalized for alcohol abuse or dependence. Psychiatr Serv 1995; 46: 618–20

    PubMed  CAS  Google Scholar 

  47. Kaufman J, Birmaher B, Brent D, et al. Schedule for affective disorders and schizophrenia for school-age children — present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997; 36(7): 980–8

    Article  PubMed  CAS  Google Scholar 

  48. Department of Psychiatry, University of Pittsburgh School of Medicine. Kiddie-Sads-Present and Lifetime Version (K-SADS-PL). Version 1.0. Available from URL: http://www.wpic.pitt.edu/ksads [Accessed 2002 May 22]

  49. Spitzer R, Williams J, Gibbon B, et al. Structured clinical interview for DSM-III-R. Biometrics Research Development. New York: New York State Psychiatric Institute, 1990

    Google Scholar 

  50. Martin CS, Pollock NK, Bukstein OG, et al. Inter-rater reliability of the SCID alcohol and substance use disorders section among adolescents. Drug Alcohol Depend 2000; 59: 173–6

    Article  PubMed  CAS  Google Scholar 

  51. Deas D, Thomas SE. An overview of controlled studies of adolescent substance abuse treatment. Am J Addict 2001; 10(2): 178–89

    Article  PubMed  CAS  Google Scholar 

  52. Brown SA, Myers MG, Mott MA, et al. Correlates of success following treatment for adolescent substance abuse. Applied Prevent Psychol 1994; 3: 61–73

    Article  Google Scholar 

  53. Henggeler SW, Schoenwald SK, Borduin CM, et al. Multisystemic treatment of antisocial behavior in children and adolescents. New York: Guilford, 1998

    Google Scholar 

  54. Bukstein OG, Kithas J. Pharmacological treatment of substance abuse disorders. In: Rosenberg D, Gershon S, editors. Textbook of psychotherapy for child and adolescent psychiatric disorders. 2nd ed. New York: Brunner/Mazel. In press

  55. Solhkhah R, Wilens TE. Pharmacotherapy of adolescent AOD use disorders. Alcohol Health Res World 1998; 22: 122–6

    PubMed  CAS  Google Scholar 

  56. Chang PH, Steinberg MB. Alcohol withdrawal. Med Clin North Am 2001 Sep; 85(5): 1191–212

    Article  PubMed  CAS  Google Scholar 

  57. Stewart D, Brown SA. Withdrawal and dependency symptoms among adolescent alcohol and drug abusers. Addiction 1995; 90: 627–35

    Article  PubMed  CAS  Google Scholar 

  58. Garbutt JC, West SL, Carey TS, et al. Pharmacological treatment of alcohol dependence: a review of the evidence. JAMA 1999; 281(14): 1318–25

    Article  PubMed  CAS  Google Scholar 

  59. Myers WC, Donahue JE, Goldstein MR. Disulfiram for alcohol use disorders in adolescents. J Am Acad Child Adolesc Psychiatr 1995; 34: 2–4

    Google Scholar 

  60. Flannery BA, Roberts AJ, Cooney N, et al. The role of craving in alcohol use, dependence, and treatment. Alcohol Clin Exper Res 2001; 25(2): 299–308

    Article  CAS  Google Scholar 

  61. Lifrak PD, Alterman AI, O’Brien CP, et al. Naltrexone for alcoholic adolescents. Am J Psychiatry 1997; 154: 439–40

    PubMed  CAS  Google Scholar 

  62. Wold M, Kaminer Y. Naltrexone for alcohol abuse [letter]. J Am Acad Child Adolesc Psychiatry 1997; 36: 6–7

    Article  PubMed  CAS  Google Scholar 

  63. Littleton J. Acamprosate in alcohol dependence: how does it work. Addiction 1995; 90: 1179–88

    Article  PubMed  CAS  Google Scholar 

  64. Kranzler HR, Van Kirk J. Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. Alcohol Clin Exper Res 2001; 25(9): 1335–41

    Article  CAS  Google Scholar 

  65. Emslie GJ, Rush AJ, Weinberg WA, et al. A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression. Arch Gen Psychiatry 1997; 54: 1031–7

    Article  PubMed  CAS  Google Scholar 

  66. Cornelius JR, Salloum IM, Ehler JG, et al. Fluoxetine in depressed alcoholics: a double-blind, placebo-controlled trial. Arch Gen Psychiatry 1997; 54: 700–5

    Article  PubMed  CAS  Google Scholar 

  67. Cornelius JR, Bukstein O, Lynch K, et al. Fluoxetine in adolescents with major depression and an adolescent alcohol use disorder: an open label trial. Addict Behav 2001; 26: 735–9

    Article  PubMed  CAS  Google Scholar 

  68. Deas D, Randall CL, Roberts JS, et al. A double-blind, placebo-controlled trial of sertraline in depressed adolescent alcoholics: a pilot study. Human Psychopharmacol 2000; 15(6): 461–9

    Article  CAS  Google Scholar 

  69. Wilens TE. AOD use and attention deficit/hyperactivity disorder. Alcohol Health Res World 1998; 22(2): 127–30

    PubMed  CAS  Google Scholar 

  70. Spencer T, Biederman J, Wilens T, et al. Pharmacotherapy of attention-deficit hyperactivity disorder across the life cycle. J Am Acad Child Adolesc Psychiatry 1996; 24: 325–47

    Google Scholar 

  71. Smith BH, Pelham WE, Gnagy E, et al. Equivalent effects of stimulant treatment for attention-deficit hyperactivity disorder during childhood and adolescence. J Am Acad Child Adolesc Psychiatry 1998; 37: 314–21

    Article  PubMed  CAS  Google Scholar 

  72. Klein RG, Abikoff H, Klass E, et al. Clinical efficacy of methylphenidate in conduct disorder with and without attention deficit hyperactivity disorder. Arch Gen Psychiatry 1997; 54: 1073–80

    Article  PubMed  CAS  Google Scholar 

  73. Biederman J, Wilens T, Mick E, et al. Pharmacotherapy of attention-deficit hyper-activity disorder reduces risk for substance use disorder. Pediatrics 1999; 104: E20

    Article  PubMed  CAS  Google Scholar 

  74. Kauffman RE. Clinical trials in children: problems and pitfalls. Paediatr Drugs 2000; 2(6): 411–8

    Article  PubMed  CAS  Google Scholar 

  75. Ackerman TF. The ethics of drug research in children. Paediatr Drugs 2001; 3(1): 29–41

    Article  PubMed  CAS  Google Scholar 

  76. Bukstein OG, van Hasselt VB. Alcohol and drug abuse. In: Bellack AS, Hersen M, editors. Handbook of behavior therapy in the psychiatric setting. New York: Plenum Press, 1993: 453–75

    Google Scholar 

  77. Kazdin AE. Conduct disorder. 2nd ed. Newbury Park (CA): Sage, 1995

    Google Scholar 

  78. Kaminer Y, Burleson JA, Blitz C, et al. Psychotherapies for adolescent substance abusers: a pilot study. J Nerv Ment Dis 1998; 186: 684–90

    Article  PubMed  CAS  Google Scholar 

  79. Waldron HB, Slesnick N, Brody JL, et al. Treatment outcomes for adolescent substance abuse at 4- and 7-month assessments. J Consult Clin Psychol 2001; 69: 802–13

    Article  PubMed  CAS  Google Scholar 

  80. Williams RJ, Chang SY. A comprehensive and comparative review of adolescent substance abuse treatment outcome. Clin Psychol Sci Prac 2000; 7: 138–66

    Article  Google Scholar 

  81. Liddle HA, Dakof GA, Parker K, et al. Multidimensional family therapy for adolescent drug abuse: results of a randomized clinical trial. Am J Drug Alcohol Abuse 2001; 27: 651–88

    Article  PubMed  CAS  Google Scholar 

  82. Henggeler SW, Borduin CM, Melton GB, et al. Effects of multisystemic therapy on drug use and abuse in serious juvenile offenders: aprogress report from two outcome studies. Fam Dynamics Addict Q 1991; 1: 40–51

    Google Scholar 

  83. Geller B, Cooper TB, Sun K, et al. Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency. J Am Acad Child Adolesc Psychiatry 1998; 37: 171–8

    Article  PubMed  CAS  Google Scholar 

  84. Riggs PD, Mikovich SK, Coffman LM, et al. Fluoxetine in drug-dependent delinquents with major depression: an open trial. J Child Adolesc Psychopharmacol 1997; 7: 87–95

    Article  PubMed  CAS  Google Scholar 

  85. Tarter RE, Vanyukov M, Giancola P, et al. Etiology of early age onset substance use disorder: a maturational perspective. Development Psychopathol 1999; 11: 657–83

    Article  CAS  Google Scholar 

  86. Rohde P, Lewinsohn PM, Kahler CW, et al. Natural course of alcohol use disorders from adolescence to young adulthood. J Am Acad Child Adolesc Psychiatry 2001; 40(1): 83–90

    Article  PubMed  CAS  Google Scholar 

  87. Helzer JE, Burnam A, McEvoy LT. Alcohol abuse and dependence. In: Robins L, Regier D, editors. Psychiatric disorders in America: the epidemiologic catchment area study. New York: MacMillan, 1991: 81–115

    Google Scholar 

  88. Muthen B, Muthen LK. Integrating person-centered and variable-centered analyses: growth mixture modeling with latent trajectory classes. Alcohol Clin Exper Res 2000; 24: 882–91

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The preparation of this manuscript was supported by grants from the National Institute on Alcohol Abuse and Alcoholism (K02AA000291, K24AA00301, R01AA13370), and the National Institute on Drug Abuse (R01DA14635, R01DA12845).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Duncan B. Clark.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Clark, D.B., Bukstein, O. & Cornelius, J. Alcohol Use Disorders in Adolescents. Pediatr-Drugs 4, 493–502 (2002). https://doi.org/10.2165/00128072-200204080-00002

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00128072-200204080-00002

Keywords

Navigation