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Acute Kidney Injury in a Patient with Melanuria, Diffuse Melanosis, and Metastatic Malignant Melanoma

  • Case Report
  • Acute Kidney Injury Secondary to Melanuria
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American Journal of Clinical Dermatology Aims and scope Submit manuscript

Abstract

Diffuse melanosis with melanuria is a rare complication of metastatic malignant melanoma that is associated with a very poor prognosis. Acute kidney injury secondary to melanuria has not been reported previously. We describe a patient with malignant melanoma, diffuse melanosis, and melanuria who developed acute kidney injury that was clinically indicated by an increase in urinary excreted metabolites in the serum. Histopathologic examination of kidney tissue revealed damage to tubules associated with disseminated intra-tubular melanin deposits. Diffuse melanosis with melanuria may lead to morphologic and functional kidney changes and warrants careful monitoring of kidney function in affected malignant melanoma patients.

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Acknowledgments

No sources of funding were used to assist in the preparation of this case report. The authors have no conflicts of interest that are directly relevant to the content of this case report.

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Authors and Affiliations

  1. Department of Dermatology, Ruhr-University Bochum, Gudrunstr. 56, D-44791, Bochum, Germany

    Thilo Gambichler, Markus Stücker, Katja Kerner, Peter Altmeyer & Alexander Kreuter

  2. Center for Dialysis, Nephrology, and Rheumatology, II Medical Department, Trier, Germany

    Stefan Weiner

  3. Private Practice for Pathology and Cytology, Heidelberg, Germany

    Rüdiger Waldherr

Authors
  1. Thilo Gambichler
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  2. Markus Stücker
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  3. Katja Kerner
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  4. Stefan Weiner
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  5. Rüdiger Waldherr
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  6. Peter Altmeyer
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  7. Alexander Kreuter
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Corresponding author

Correspondence to Thilo Gambichler.

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Gambichler, T., Stücker, M., Kerner, K. et al. Acute Kidney Injury in a Patient with Melanuria, Diffuse Melanosis, and Metastatic Malignant Melanoma. Am J Clin Dermatol 9, 267–270 (2008). https://doi.org/10.2165/00128071-200809040-00007

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  • DOI: https://doi.org/10.2165/00128071-200809040-00007

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