EVALUATION OF SERUM 25-HYDROXYVITAMIN D IN CHILDREN WITH CHRONIC KIDNEY DISEASE ON DIALYSIS AT ZAGAZIG UNIVERSITY CHILDREN HOSPITALS

Document Type : Original Article

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1 Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

2 Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Abstract

ABSTRACT
Background: Vitamin D deficiency and insufficiency in chronic kidney disease (CKD) patients on dialysis is associated with undesirable outcomes as rapid progression to later stages of renal insufficiency, and greater risk of mortality. At the mean time data is limited regarding if vitamin D deficiency and insufficiency is more present in children with chronic kidney disease on dialysis or not.
Subjects and Methods: In this cross sectional study, 42 pediatric patients aged from 3-16 years with CKD on dialysis were enrolled, Serum serum 25-hydroxyvitamin D (25(OH)D) levels were determined by enzyme-linked immunosorbent assay (ELISA).
Results: Out of 42 pediatric patients, 71.4% of the patients had 25(OH)D deficiency, 26.2% had vitamin D insufficiency and only 2.4% were vitamin D sufficient. 25(OH)D insufficiency and deficiency is more prevalent in more severe cases of CKD and also more prevalent in children with longer duration of dialysis.
Conclusion: CKD patients on dialysis therapy are more likely to have 25(OH)D deficiency or insufficiency, vitamin D deficiency and insufficiency increase by increasing the severity of CKD and increasing the duration of dialysis.
Keywords: Vitamin D, chronic kidney disease, dialysis.

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