SPECTROPHOTOMETRIC DETERMINATION OF AMLODIPINE BESILATE, BISOPROLOL HEMIFUMARATE AND SOTALOL HCL THROUGH OXIDATION REDUCTION REACTION

Document Type : Original Article

Authors

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University. Zagazig. Egypt.

Abstract

Two simple sensitive and accurate methods have been developed for the determination of amlodipine besilate, bisoprolol hemifumarate and sotalol HCl through oxidation-reduction reaction. The first method involves the oxidation of the drugs With cerium(IV) sulphate in acidic medium and subsequent measurement of the decrease in reagent absorbance at 318 nm in the concentration ranges of 0.2-1.4, 0.25-2.75 and 0.5-4 µg ml-1 of amlodipine besilate, bisoprolo! hemifumarate and sotalol HCI, respectively. The second method is based on the oxidation of the selected drugs with known excess cerium (IV) sulphate in acidic medium followed by determination of the unreacted cerium(IV) by measuring the decrease in absorbance of chromotrope 2R(C2R) at ʎ max 508 nm in the concentration ranges of 1.25-4.5, 0.75-3.25 and 0.5-3 µg ml-1 of amlodipine besilate, bisoprolol hemifumarate and sotalol HCI, respectively. The proposed methods were successfully applied for the analysis of the investigated drugs pharmaceutical dosage forms. Results obtained by the proposed methods were compared With those obtained by the reference methods and no significant differences were found.

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