REACTIONS OF 2,3-DICHLOROMALEIC ANHYDRIDE(1): II REACTIONS WITH BINUCLEOPHILES (4+2CYCLOCONDENSATION) FOR SYNTHESIS OF COMPOUNDS WITH POTENTIAL ANTIMICROBIAL ACTIVITY

Document Type : Original Article

Authors

1 Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

2 Pharmazeutisches Institute der Universitaet Bonn, Kreuzbergweg 26, D-5300 Bonn 1, Germany

3 Department of Microbiology, Faculty of Pharmacy, Zagazig University, Egypt

4 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

5 Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

Abstract

The reaction of 2,3-dichloromaleimides 1a-f with binucleophiles, viz, o-aminophenol (2a) and o-phenylenediamine (2b) is described. Products isolated were dependent on both pH and the used reaction solvents. Many of the novel, fused pyrroloquinoxalines and maleimides showed remarkable antimicrobial activities.

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