PROTECTIVE EFFECT OF AVOCADO FRUIT (Persea americana) POWDER AND EXTRACT AGAINST HEPATIC INJURY IN EXPERIMENTAL RATS

نوع المستند : المقالة الأصلية

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The purpose of this study was to investigate the protective efficacy of avocado fruit (Persea americana) powder and extract against paracetamol induced hepatic injury in rats. Forty male Sprague-Dawley rats weighing (115 ± 10) (8 rats), were divided into five groups: normal control group (-ve), paracetamol control  single dose of (2 g/kg/b.wt/rat) as control (+ve), and the other three treated groups were with 5 g/kg/diet/day avocado powder, 0.5 ml /kg/ b.wt/ rats/day avocado extract by stomach tube and mixture with 5 g/kg/diet/day avocado powder and 0.5 ml /kg/ b.wt/ rats/day avocado extract. The result revealed that all of the treated groups showed significant increase in body weight gain, serum HLDL-C, total protein, total antioxidant capacity, SOD levels. Moreover, significant decrease serum TC, TG, LDL-C, VLDL-C, AST, ALT, alkaline phosphotase enzymes (Alk-Pho), total bilirubin and nitric oxide (NO) in comparing to positive control group. The current study suggests that avocado powder and extract may be content of the phytochemical such as tannins, saponins, glycoside, flavonoids and carbohydrates beneficial as a protective antioxidant supplement with promising antioxidant potential to combat paracetamol induced hepatic injury in rats.

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