The effects of weight loss intervention program on serum leptin level, histological and molecular alterations of adipose tissue in rat model with obesity.

Document Type : Original Article

Authors

1 Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

2 Biochemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt

3 Organic Chemistry Department, Faculty of Science Zagazig University, Zagazig, Egypt.

4 Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig Egypt.

Abstract

Background: Obesity is a resilient and complex chronic disease.
Leptin is an adipocyte-derived hormone acts as a key regulator of feeding and energy expenditure.
The aim of our study was to assess the level of serum leptin as well as leptin immuno-histochemistry expression in adipose tissue in obese and non-obese rats.
Leptin was markedly detected in young preadipocytes during lipogenesis (before weight loss (regime) in contrast to adipocytes undergoing lipolysis (after weight loss (regime) in the later weak positive.