The prevalence and clinical features of asthma-COPD overlap (ACO) definitively diagnosed according to the Japanese Respiratory Society Guidelines for the Management of ACO 2018

Kenta Yamamura; Johsuke Hara; Takafumi Kobayashi; Noriyuki Ohkura; Miki Abo; Kyota Akasaki; Syunichi Nomura; Mizuki Yuasa; Keigo Saeki; Nanao Terada; Hiroki Matsuoka; Yuichi Tambo; Shingo Nishikawa; Takashi Sone; Hideharu Kimura; Kazuo Kasahara

doi:10.2152/jmi.66.157

Kenta Yamamura, Johsuke Hara, Takafumi Kobayashi, Noriyuki Ohkura, Miki Abo, Kyota Akasaki, Syunichi Nomura, Mizuki Yuasa, Keigo Saeki, Nanao Terada, Hiroki Matsuoka, Yuichi Tambo, Shingo Nishikawa, Takashi Sone, Hideharu Kimura, Kazuo Kasahara

Author information

Kenta Yamamura
Department of Respiratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University [Japan]
Johsuke Hara
Department of Respiratory Medicine, Kanazawa University Hospital [Japan]
Takafumi Kobayashi
Department of Respiratory Medicine, Kanazawa University Hospital [Japan]
Noriyuki Ohkura
Department of Respiratory Medicine, Kanazawa University Hospital [Japan]
Miki Abo
Department of Respiratory Medicine, Kanazawa University Hospital [Japan]
Kyota Akasaki
Department of Respiratory Medicine, Kanazawa University Hospital [Japan]
Syunichi Nomura
Department of Respiratory Medicine, Kanazawa University Hospital [Japan]
Mizuki Yuasa
Department of Respiratory Medicine, Kanazawa University Hospital [Japan]
Keigo Saeki
Department of Respiratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University [Japan]
Nanao Terada
Department of Respiratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University [Japan]
Hiroki Matsuoka
Department of Respiratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University [Japan]
Yuichi Tambo
Department of Respiratory Medicine, Kanazawa University Hospital [Japan]
Shingo Nishikawa
Department of Respiratory Medicine, Kanazawa University Hospital [Japan]
Takashi Sone
Department of Regional Respiratory Symptomatology, Kanazawa University Graduate School of Medical Science [Japan]
Hideharu Kimura
Department of Respiratory Medicine, Kanazawa University Hospital [Japan]
Kazuo Kasahara
Department of Respiratory Medicine, Kanazawa University Hospital [Japan]

Keywords: Asthma-COPD overlap (ACO), bronchial asthma (BA), chronic obstructive pulmonary disease (COPD), prevalence, pulmonary function

JOURNAL FREE ACCESS

2019 Volume 66 Issue 1.2 Pages 157-164

DOI https://doi.org/10.2152/jmi.66.157

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Abstract

Background Asthma-COPD overlap (ACO) is a disease that shares clinical features of both asthma and COPD. The purpose of this study is to investigate the prevalence and clinical features of ACO. Methods We retrospectively reviewed data for 170 patients with persistent airflow limitation and diagnosed them according to “The Japanese Respiratory Society Guidelines for the Management of ACO 2018”. Results Of the 170 patients, 111 were diagnosed as follows : COPD (74 patients, 66.6%), ACO (34 patients, 30.6%), and asthma (3 patients, 2.8%). There was no significant difference in clinical features between ACO and COPD patients. The following pulmonary function tests were significantly lower in ACO than in COPD patients : forced expiratory volume in 1 second/forced vital capacity, peak expiratory flow, maximal mid-expiratory flow, and the maximum expiratory flow at 50%and75%. The following respiratory impedance parameters were significantly higher in ACO than in COPD patients : respiratory resistance (Rrs) at 5 Hz (R5), Rrsat 20 Hz (R20), R5-R20, and low-frequency reactance area. Conclusions About 30% of patients with persistent airflow limitation were diagnosed with ACO. ACO patients had lower lung function and higher respiratory impedance compared with COPD patients. J. Med. Invest. 66 : 157-164, February, 2019

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