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Effect of anions or foods on absolute bioavailability of calcium from calcium salts in mice by pharmacokinetics
Authors Ueda Y, Zenei Taira Z
Received 9 June 2013
Accepted for publication 26 July 2013
Published 16 October 2013 Volume 2013:5 Pages 65—71
DOI https://doi.org/10.2147/JEP.S49668
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Yukari Ueda, Zenei Taira
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan
Abstract: We studied the absolute bioavailability of calcium from calcium L-lactate in mice using pharmacokinetics, and reviewed the absolute bioavailability of calcium from three other calcium salts in mice previously studied: calcium chloride, calcium acetate, and calcium ascorbate. The results showed that calcium metabolism is linear between intravenous administration of 15 mg/kg and 30 mg/kg, and is not affected by anions. Results after oral calcium administration of 150 mg/kg showed that the intestinal absorption process was significantly different among the four calcium salts. The rank of absolute bioavailability of calcium was calcium ascorbate > calcium L-lactate ≥ calcium acetate > calcium chloride. The mean residence time (MRTab) of calcium from calcium ascorbate (32.2 minutes) in the intestinal tract was much longer than that from calcium L-lactate (9.5 minutes), calcium acetate (15.0 minutes) and calcium chloride (13.6 minutes). Furthermore, the foods di-D-fructo-furanose-1,2':2,3'-dianhydride, sudachi (Citrus sudachi) juice, and moromi-su (a Japanese vinegar) increased the absolute bioavailability of calcium from calcium chloride by 2.46-fold, 2.86-fold, and 1.23-fold, respectively, and prolonged MRTab by 48.5 minutes, 43.1 minutes, and 44.9 minutes, respectively. In conclusion, the prolonged MRTab of calcium in the intestinal tract by anion or food might cause the increased absorbability of calcium.
Keywords: absolute bioavailability of calcium, pharmacokinetics, calcium chloride, calcium L-lactate, DFA III, sudachi juice
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