SummaryIn this study, we addressed the role of IL-10-producing ILCs in controlling grass pollen allergy. IL-10+ ILCs are comprised in KLRG1+ILC2-lineage cells and absent on CRTH2+ ILC2 which lack KLRG1. We observed that ILC2s in healthy subjects and grass pollen allergic patients show differential gene expression profiles. A cross-sectional study demonstrates that IL-10-producing KLRG1+ ILC2s are strongly reduced in patients with grass pollen and house dust mite allergy when compared to healthy subjects and those who have received grass pollen subcutaneous immunotherapy treatment. In a prospective double-blind, placebo-controlled trial of grass pollen sublingual immunotherapy (SLIT), we observed that the capacity of ILC2 to produce IL-10 was restored in patients who received SLIT, but not patients receiving a placebo. Finally, we demonstrated that these IL-10-producing ILCs are functional and play a crucial role in restoring barrier function and tissue balance in allergic diseases.
Golebski, Korneliusz and Layhadi, Janice A. and Sahiner, Umit and Steveling-Klein, Esther H. and Lenormand, Madison M. and Li, Rachael C. Y. and Bal, Suzanne M. and Heesters, Balthasar and Vilà-Nadal, Gemma and Fedina, Oleksandra and Lao-Araya, Mongkol and Vijverberg, Susanne J. H. and Maitland-van der Zee, Anke-Hilse and van Drunen, Cornelis M. and Fokkens, Wytske J. and Durham, Stephen R. and Spits, Hergen and Shamji, Mohamed, Immunotherapy for Upper Airway Disease Generates IL-10-Producing KLRG1
+ ILC2s that are Associated with Clinical Benefit. Available at SSRN: https://ssrn.com/abstract=3611048 or http://dx.doi.org/10.2139/ssrn.3611048
This version of the paper has not been formally peer reviewed.
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