University of Minnesota - Minneapolis - Department of Rehabilitation Medicine; University of Minnesota - Minneapolis - Division of Physical Therapy
Date Written: May 1, 2018
Abstract
Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing greater deterioration in females about the time estrogen levels decrease at menopause. Here we show that maintenance of muscle stem cells, satellite cells, as well as self-renewal and differentiation into muscle fibers, are severely compromised by estrogen deficiency. Mechanistically, by hormone replacement, use of a selective estrogen-receptor modulator (bazedoxifene), and conditional estrogen receptor knockout, we implicate 17β-estradiol and satellite cell expression of estrogen receptor alpha (ERalpha) and show that estrogen signaling through this receptor is necessary to prevent apoptosis of satellite cells. Early data from a biopsy study of women who transitioned from peri- to post-menopause are consistent with the loss of satellite cells coincident with the decline in estradiol in humans. Together, these results demonstrate an important role for estrogen in satellite cell maintenance and muscle regeneration in females.
Collins, Brittany and Collins, Brittany and Arpke, Robert and Arpke, Robert and Larson, Alexie and Baumann, Cory and Baumann, Cory and Cabelka, Christine and Cabelka, Christine and Nash, Nardina and Juppi, Hanna and Laakkonen, Eija and Sipila, Sarianna and Kovanen, Vuokko and Spangenburg, Espen and Kyba, Michael and Lowe, Dawn, Estrogen Regulates the Satellite Cell Compartment in Females (May 1, 2018). Available at SSRN: https://ssrn.com/abstract=3188128 or http://dx.doi.org/10.2139/ssrn.3188128
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