Cent Eur J Public Health 2018, 26(4):272-277 | DOI: 10.21101/cejph.a4921

HSPB7 gene polymorphism associated with anthropometric parameters of obesity and fat intake in a Central European population

Tereza Pavlová1,2, Jan Novák1,3, Filip Zlámal1,2, Julie Bienertová-Vašků1,2
1 Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
2 Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Brno, Czech Republic
3 Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

Objective: Heat shock proteins act as chaperones at the molecular level and therefore they have been investigated in numerous diseases associated with oxidative stress, including obesity. The aim of this study was to investigate the possible associations of genetic variability in the 3´-untranslated region of the HSPB7 gene (rs1048261) with anthropometric and dietary parameters in a cohort of lean and obese Central European subjects.

Methods: A total of 708 Central European Caucasian individuals were enrolled in this study, 415 obese subjects and 293 non-obese subjects. The rs1048261 genotypes were established using a conventional PCR-based methodology.

Results: Significant differences were observed in the total daily fat intake between subjects with AT and TT genotypes (82.6 ± 29.2 g vs. 74.1 ± 31.3 g, p = 0.023) and also borderline significance in daily proportion of fat in the diet between AA and TT genotypes (36.0 ± 4.4% vs. 33.3 ± 5.9%, p = 0.061). Based on the linear regression model we found association between rs1048261 genotype and body fat percentage.

Conclusions: To the best of our knowledge, this is the first study which reports an association of defined genetic variability in the HSPB7 gene, rs1048261, with obesity and its associated anthropometric characteristics and dietary composition.

Keywords: HSPB7, obesity, polymorphism, dietary composition, fat intake, rs1048261

Received: September 6, 2016; Revised: November 20, 2018; Accepted: November 20, 2018; Published: December 31, 2018  Show citation

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Pavlová T, Novák J, Zlámal F, Bienertová-Vašků J. HSPB7 gene polymorphism associated with anthropometric parameters of obesity and fat intake in a Central European population. Cent Eur J Public Health. 2018;26(4):272-277. doi: 10.21101/cejph.a4921. PubMed PMID: 30660137.

Correction of an error in the Table 2 published in Cent Eur J Public Health 2019, 27(1):83

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