The objective of the present paper is to investigate two characteristics; task performance and muscular load during both skill and post-skill processes for the pen-tablet input system with the mouse input system on the PC. A total of five right-handed subjects with at least a year of experience in PC-use and without any history of the pen-tablet use participated in the study. Two computer-drawing tasks (straight-line drawing task and polygon tracing task) for evaluating the system were designed. Dependent measures included performance parameters such as duration time to complete each drawing and error rates, and surface electromyography (EMG). When the pen-tablet system was being used, low amplitudes of EMGs for the biceps brachii, the flexor digitorum superficialis, and the extensor digitorum were found, whereas EMG for the trapezius appeared to be high. On the first day, the performance with the mouse was much higher than the performance with the pen-tablet system in terms of error rates and the number of completed trials. However, the performance with the pen-tablet system exceeded the performance with the mouse from the second day on, and subjects performed better with the pen-tablet system than with the mouse. The overall results imply that the skill process for the pen-tablet system was very short and the subjects felt comfortable to use the new system in general and physiological measures supported the subjective reports by the subjects as well.