Establishment of the menthol test as a clinical evaluation method for oxaliplatin-induced neuropathy

Yeongcheol Cheong; Hidetoshi Katsuno; Hiroshi Matsuoka; Masahiro Mizuno; Tomoyoshi Endo; Tadahiro Kamiya; Yosuke Tajima; Keigo Ashida; Yoshikazu Koide; Koji Masumori; Harunobu Sato; Tsunekazu Hanai; Kotaro Maeda; Ichiro Uyama; Junichiro Hiro; Koichi Suda

doi:10.20407/fmj.2021-011

Original Article

Establishment of the menthol test as a clinical evaluation method for oxaliplatin-induced neuropathy

Yeongcheol Cheong, Hidetoshi Katsuno, Hiroshi Matsuoka, Masahiro Mizuno, Tomoyoshi Endo, Tadahiro Kamiya, Yosuke Tajima, Keigo Ashida, Yoshikazu Koide, Koji Masumori, Harunobu Sato, Tsunekazu Hanai, Kotaro Maeda, Ichiro Uyama, Junichiro Hiro, Koichi Suda

Author information

Yeongcheol Cheong
Department of Gastroenterological Surgery, Fujita Health University, School of Medicine
Hidetoshi Katsuno
Department of Gastroenterological Surgery, Fujita Health University, School of Medicine
Hiroshi Matsuoka
Department of Gastroenterological Surgery, Fujita Health University, School of Medicine
Masahiro Mizuno
Department of Surgery, Ieda Hospital
Tomoyoshi Endo
Department of Gastroenterological Surgery, Fujita Health University, School of Medicine
Tadahiro Kamiya
Department of Gastroenterological Surgery, Fujita Health University, School of Medicine
Yosuke Tajima
Department of Gastroenterological Surgery, Fujita Health University, School of Medicine
Keigo Ashida
Department of Surgery, Tottori Prefectural Central Hospital
Yoshikazu Koide
Department of Gastroenterological Surgery, Fujita Health University, School of Medicine
Koji Masumori
Department of Gastroenterological Surgery, Fujita Health University, School of Medicine
Harunobu Sato
Department of Gastroenterological Surgery, Fujita Health University, School of Medicine
Tsunekazu Hanai
Department of Advanced Robotic and Endoscopic Surgery, Fujita Health University, School of Medicine
Kotaro Maeda
International Medical Center, Fujita Health University Hospital
Ichiro Uyama
Department of Advanced Robotic and Endoscopic Surgery, Fujita Health University, School of Medicine
Junichiro Hiro
Department of Gastroenterological Surgery, Fujita Health University, School of Medicine
Koichi Suda
Department of Gastroenterological Surgery, Fujita Health University, School of Medicine

Keywords: Menthol, Oxaliplatin-induced neuropathy, OPN, Oxaliplatin

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Supplementary material

2022 Volume 8 Issue 3 Pages 88-95

DOI https://doi.org/10.20407/fmj.2021-011

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Abstract

Objectives: To determine whether the tongue menthol test, which measures the cold sensation detection threshold (CDT) of the tongue, used before and after oxaliplatin administration is an objective evaluation method for oxaliplatin-induced peripheral neuropathy (OPN).

Methods: The tongue menthol test was administered to patients both before and after undergoing chemotherapy containing oxaliplatin for colorectal cancer. The tongue menthol test was conducted by applying a menthol solution (a selective agonist of transient receptor potential cation channel subfamily M member 8 [TRPM8]) to the tongue and measuring the CDT.

Results: The mean CDT before the first dose of oxaliplatin was 0.34% (0.005%–1%; n=38), and the mean CDT after the first dose was 0.32% (0.005%–1%; n=38). The CDT appeared to decrease after the first dose, but this difference was not significant. In patients who received five courses of oxaliplatin, changes in CDT values were compared before and after the five courses. In patients with Neurotoxicity Criteria of Debiopharm (DEB-NTC) grade 2 neuropathy, the pre-oxaliplatin administration CDT was compared between before grade exacerbation and when exacerbation occurred, and was found to decline when grade exacerbation occurred. Moreover, when the CDTs before and after administration were compared before grade exacerbation, there was a significant decrease in CDT after administration (P=0.04).

Conclusions: By performing a menthol test in oxaliplatin-treated patients, it may be possible to objectively predict the exacerbation of peripheral neuropathy at an early stage.

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