Knowledge Network Node

Meta-analysis of RCT studies on clinical efficacy of single administration of Tripterygium Glycosides Tablets or combined administration with methotrexate against rheumatoid arthritisChinese Full TextEnglish Full Text (MT)

CHEN Wen-jia;LI Tai-xian;WANG Xiao-yue;XUE Zhi-peng;LYU Cheng;LI Hui-zhen;LI Yi-qun;FAN Yuan-fang;TIAN Ya-ge;YANG Jun;GUO Min-qun;WANG Jing-xia;WU Hong-yan;ZHANG Yan-qiong;LIN Na;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences;Wangjing Hospital, China Academy of Chinese Medical Sciences;Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences;

Abstract: To evaluate the clinical efficacy of single administration of Tripterygium Glycosides Tablets(TGT) or combined administration with methotrexate(MTX) against rheumatoid arthritis(RA) based on American College of Rheumatology(ACR) efficacy standard. Six databases, namely CNKI, WanFang, VIP, PubMed, Embase and Cochrane Library, were retrieved for randomized controlled trials(RCT), and clinical trials were screened out according to the preset inclusion and exclusion criteria. Then, the study quality was evaluated by the risk assessment tools. Data extraction and analysis were performed by using RevMan 5.3 software for Meta-analysis. Sensitivity analysis and publication bias analysis were made to test the stability and reliability of results. Until December 2018, a total of 1 709 articles were obtained, and finally 10 clinical RCT studies with a total of 1 184 patients were included. As a result, the single administration of TGT showed a significantly better ACR efficiency(RR=1.31, 95%CI[1.15, 1.49], P<0.000 1) than methotrexate(MTX). The combined administration of TGT and MTX showed a significantly better ACR efficiency(RR=1.28, 95%CI[1.20, 1.38], P<0.000 01) than the single administration of MTX. In conclusion, the single administration of TGT and the combined administration of TGT and MTX were more effective in achieving ACR20, ACR50, ACR70 compliance than the single administration of MTX. Further validations based on more RCT studies with high-quality are required.
  • DOI:

    10.19540/j.cnki.cjcmm.20191115.503

  • Series:

    (E) Medicine & Public Health

  • Subject:

    Endocrine and Systemic Disease

  • Classification Code:

    R593.22

Download the mobile appuse the app to scan this coderead the article.

Tips: Please download CAJViewer to view CAJ format full text.

Download: 985 Page: 791-797 Pagecount: 7 Size: 2727K

Related Literature
  • Similar Article
  • Reader Recommendation
  • Associated Author