Prevalence and impact of adiposity and sarcopenia during rheumatoid arthritis: rapid and non-invasive evaluation in Sub-Saharan African women

Authors

  • Maïmouna Touré Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
  • Mouhamed T. Diagne Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
  • Amadou Badji Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
  • Souleymane Thiam Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
  • Coumba Diouf Department of Rheumatology, LeDantec University Hospital, Cheikh Anta Diop University, Dakar, Senegal
  • Moustapha Niasse Department of Rheumatology, LeDantec University Hospital, Cheikh Anta Diop University, Dakar, Senegal
  • Mbaye Sene Laboratory of Pharmaceutical Physiology, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
  • Abdou Khadre Sow Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
  • Aissatou Seck Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
  • Salimata D. Houndjo Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
  • Mor Diaw Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
  • Arame Mbengue Physiology Laboratory, Faculty of Health Sciences, Bamoko-Cheikh Anta Diop University, Dakar, Senegal
  • Fatou Bintou Sar Physiology Laboratory, Faculty of Health Sciences, Bamoko-Cheikh Anta Diop University, Dakar, Senegal
  • Abdoulaye Bâ Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
  • Seydou Diallo Department of Rheumatology, LeDantec University Hospital, Cheikh Anta Diop University, Dakar, Senegal
  • Abdoulaye Samb Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

DOI:

https://doi.org/10.18203/2320-6012.ijrms20193371

Keywords:

Adiposity, Metabolic age, Rheumatoid arthritis, Sarcopenia, Sub-Saharan African women

Abstract

Background: Body composition plays a fundamental role in the occurrence of complications in rheumatoid arthritis. Authors conducted this study, which aimed to determine body composition and its effects on physiological status in African sub-Saharan polyarthritis women.

Methods: The anthropometric parameters were measured after an interview and a complete physical examination. The body composition was evaluated using a Tanita® brand bioimpedance meter. Finally, all the patients had a dosage of certain biochemical parameters.

Results: An excess of percent fat mass was noted in more than half of women (59.52%) without loss of muscle mass. At the same time, 30% of women had a significant decrease in the percentage of body water. The BMI did not appear to be an adequate proxy for these changes. Visceral fat level was elevated just in 16% of women, however it would be a determinant of physiological aging of subjects. Dual therapy methotrexate and corticosteroid would have varying effects depending on the duration and the dose of treatment. The basic metabolism in polyarthritic subjects would be dependent on two parameters namely muscle mass and inflammatory state.

Conclusions: Evaluating changes in body composition quickly, non-invasively and inexpensively is possible. It could be useful in the follow-up of rheumatoid arthritis. Managing these changes can reduce cardiovascular morbidity and mortality in rheumatoid arthritis.

Author Biographies

Maïmouna Touré, Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

 

Souleymane Thiam, Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

 

Moustapha Niasse, Department of Rheumatology, LeDantec University Hospital, Cheikh Anta Diop University, Dakar, Senegal

 

Mbaye Sene, Laboratory of Pharmaceutical Physiology, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

 

Abdou Khadre Sow, Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

 

Aissatou Seck, Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

 

Salimata D. Houndjo, Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

 

Mor Diaw, Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

 

Fatou Bintou Sar, Physiology Laboratory, Faculty of Health Sciences, Bamoko-Cheikh Anta Diop University, Dakar, Senegal

 

Abdoulaye Bâ, Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

 

Seydou Diallo, Department of Rheumatology, LeDantec University Hospital, Cheikh Anta Diop University, Dakar, Senegal

 

Abdoulaye Samb, Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

 

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Published

2019-07-25

How to Cite

Touré, M., Diagne, M. T., Badji, A., Thiam, S., Diouf, C., Niasse, M., Sene, M., Sow, A. K., Seck, A., Houndjo, S. D., Diaw, M., Mbengue, A., Sar, F. B., Bâ, A., Diallo, S., & Samb, A. (2019). Prevalence and impact of adiposity and sarcopenia during rheumatoid arthritis: rapid and non-invasive evaluation in Sub-Saharan African women. International Journal of Research in Medical Sciences, 7(8), 2920–2927. https://doi.org/10.18203/2320-6012.ijrms20193371

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Original Research Articles