Research Article
BibTex RIS Cite

Investigation of the Biological Activities of Alcea calvertii

Year 2022, Volume: 25 Issue: 5, 955 - 964, 31.10.2022

Mahmoud Abudayyak Şeyda Kanbolat Reyyan Ergene Şeyma Batur Rezzan Aliyazıcıoğlu

https://doi.org/10.18016/ksutarimdoga.vi.890659
Cited By: 1

Abstract

Herbs are widely used in the treatment of diseases as colds, infections, and cancer. In this work, we evaluate Alcea calvertii, which is a perennial herbaceous plant belonging to the Malvaceae family. It spreads in Anatolia and Mediterranean region and has important uses in terms of ethnobotany. In this study, it was aimed to evaluate the cytotoxic potentials and to investigate the antioxidant activities of methanol, water, chloroform, and ethyl acetate extracts of the aerial parts of Alcea calvertii. For that, the antioxidant activity of Alcea calvertii was determined by four different methods [total phenolic content (TPC), ferric reducing antioxidant power (FRAP), copper reducing antioxidant capacity (CUPRAC) and 2,2-diphenylpicrylhydrazil (DPPH) radical scavenging activity. The cytotoxicity potential of extracts was assessed in the human lung cancer cell line (A549) by MTT assay. It was observed that the highest antioxidant activity was in the methanol extract and the antioxidant activity increased with increasing extract concentration; The TPC values were between 62.5 - 414.6 GAE µg mL-1, the FRAP values were between 115.7 - 1321.4 µM Trolox equivalent g-1, CUPRAC values were between 177.1 - 1321.4 µM Trolox equivalent g-1, and IC50 values in DPPH determination were between 0.0089 - 3.5370 mg mL-1. The extracts caused cytotoxicity in a concentration dependent manner, the IC50 values were calculated to be between 36.8 - 62.64 µg mL-1. It is concluded that Alcea calvertii could be an important herb in developing new drugs.

Keywords

Alcea calvertii Antioxidant Capacity cytotoxicity

Supporting Institution

TÜBİTAK 2209A

Project Number

1919B011800561

References

  • Abd El-Salam NM, Radwan MM, Wanas A, Shenouda M, Sallam S, Piacente S, ElSohly M, Ghazy N 2016. Phytochemical And Biological Evaluation of Alcea rosea L., Growing In Egypt. Planta Medica 82:2–3.
  • Abdel-salam NA, Ghazy NM, Sallam SM, Radwan MM, Wanas AS, ElSohly MA, El-Demellawy MA, Abdel-Rahman NM, Piacente S, Shenouda ML 2018. Flavonoids Of Alcea rosea L. And Their Immune Stimulant, Antioxidant and Cytotoxic Activities On Hepatocellular Carcinoma Hepg-2 Cell Line. Natural Product Research 32:702–706.
  • Abudayyak M, Ozdemir Nath E, Ozhan G 2015. Toxic Potentials of Ten Herbs Commonly Used Aphrodisiac Effect in Turkey. Turkish Journal of Medical Sciences 44: 496-506.
  • Ahmadi M, Rad AK, Rajaei Z, Hadjzadeh MAR, Mohammadian N, Tabasi NS 2012. Alcea rosea Root Extract As A Preventive And Curative Agent In Ethylene Glycol-Induced Urolithiasis In Rats. Indian Journal of Pharmacology 44:304–307.
  • Ahmed S, Hasan MM, Mahmood ZA 2016. Antiurolithiatic Plants in Different Countries and Cultures. Journal of Pharmacognosy and Phytochemistry 5: 102-115.
  • Akan H, Bakır Sade Y 2015. Ethnobotanical Investigation of Kahta (Adıyaman) Center and Narince Village [Kahta (Adıyaman) Merkezi ve Narince Köyü’nün Etnobotanik Açıdan Araştırılması] Bitlis Eren University Journal of Science 4(2): 219-248.
  • Alpertunga B, Kara M, Abudayyak M, Oztas E, Ozden S, Özhan G 2014. Effects of prochloraz on DNA damage, lipid peroxidation and antioxidant system in vitro, Toxicology Mechanisms and Methods, 24:4, 268-275
  • Alhage J, Elbitar H 2018. In Vitro Screening for Antioxidant and Antimicrobial Properties of Three Lebanese Medicinal Plants Crude Extracts 2019. Pharmacognosy Research 11(2):127–133.
  • Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, Boyd MR 1988. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Research 48: 589–601.
  • Al-Snafi AE 2013. The Pharmaceutical importance of Althaea officinalis and Althaea rosea: A review. International Journal of PharmTech Research 5:1378–1385
  • Altundag E, Ozturk M 2011. Ethnomedicinal Studies on The Plant Resources of East Anatolia, Turkey. Procedia - Social and Behavioral Sciences 19: 756-777.
  • Anlas C, Ustuner O, Alkan F, Bakirel T, Aydogan M, Erel S 2017. a Comparative Study on the Antioxidant Activities and Phenolic Contents of Different Extracts of a Chillea nobilis Subsp Sipylea and Alcea apterocarpa (Fenzl) Boiss, Endemic Plants in Turkey. Fresenius Environmental Bulletin 26:1423–1430.
  • Apak R, Güçlü K, Ozyürek M, Karademir SE, Erça E 2006. The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas. international journal food science nutrition 57:292-304.
  • Asami S, Manabe H, Miyake J, Tsurudome Y, Hirano T, Yamaguchi R, et al 1997. Cigarette smoking induces an increase in oxidative DNA damage, 8- hydroxydeoxyguanosine, in a central site of the human lung. Carcinogenesis 18:1763–1766.
  • Azab A 2016. Alcea: traditional medicine, current research and future opportunities. European Chemical Bulletin 6 (5): 505-514.
  • Azadeh Z, Saeidi K, Lorigooini Z, Kiani M, Maggi F 2020. Organ-Oriented Phytochemical Profiling and Radical Scavenging Activity of Alcea spp. (Malvaceae) from Iran. SN Applied Sciences 2:1–9. https://doi.org/10.1007/s42452-020-2410-3
  • Beğen HA and Yüksel E 2018. The flora of Alanbaşı and Bakırtepe villages (Yusufeli, Artvin, Turkey) and its surroundings. Turkish Journal of Biodiversity 1:17–23.
  • Benzie IFF, Strain JJ 1996. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Analytical Biochemistry 239: 70-6.
  • Boyzal ME and Mert EM 2018. Antiurolithiatic Activity of Medicinal Plants in Turkey. (Assessment of Working Postures of Nursery Workers in Seedling Production Activities (Ed. Christov I, Strauss E, Gad A, Curebal I) 152-162.
  • Byahatti VV, Vasantakumar Pai K, D’Souza MG 2010. Effect of Phenolic Compound from Bergenia cliata (Haw.) Stemb. Leaves on Experimental Kidney Stones. Ancient science of life 30: 14-17.
  • Chan K 2003. Some aspects of toxic contaminants in herbal medicines, Chemosphere 52: 1361–1371. Dalar A, Mukemre M, Unal M, Ozgokce F 2018. Traditional Medicinal Plants of Ağrı Province, Turkey. Journal of Ethnopharmacology 226:56–72.
  • Dar PA, Ali F, Sheikh IA, Ganie SA, Dar TA 2017. Amelioration of Hyperglycaemia and Modulation of Antioxidant Status By Alcea Rosea Seeds in Alloxan-Induced Diabetic Rats. Pharmaceutical Biology 55:1849–1855 . https://doi.org/10.1080/ 13880209.2017.1333127
  • Dhalla NS, Temsah RM, Netticadan T 2000. Role of oxidative stress in cardiovascular diseases. Journal of Hypertension 18: 655–673.
  • Doğan A, Tuzlacı E 2015. Some Local Plant Names of Tunceli [Tunceli’nin Bazı Yöresel Bitki Adları]. Eurasscience Journal 3: 22-33.
  • Ertas A, Boga M, Gazioglu I, Yesil Y, Hasimi N, Ozaslan C, Yilmaz H, Kaplan M 2016. Fatty acid, Essential Oil and Phenolic Compositions of Alcea Pallida and Alcea apterocarpa With Antioxidant, Anticholinesterase and Antimicrobial Activities. Chiang Mai Journal of Science 43:89–99 .
  • Esmaeili S, Irani M, Zehan HM, Keramatian B, Harandi ZT, Hamzeloo-Moghadam M 2016. Cytotoxic Activity of Some Ethnic Medicinal Plants From Southwest of Iran. Research Journal of Pharmacognosy 3:43–47
  • Fahimi Z, Cheraghi j, Pilehvarian AA, Sayehmiri K, Kjosarvi A 2012. Effects of Alcea angulate Roots Alcoholic Extract on Blood Lipid of Male Rabbit. Journal of Ilam University of medical Sciences 20:23-32.
  • Fahimi Z, Soltanbeigi S, Asadollahi K, Kaffashi M and Kaffashian MR 2018. Effects of Alcoholic Extract of Stem and Aerial Parts of the Alcea angulate Plant on Aorta Atherosclerotic Plaque Formation in Rabbit. Archives of Medicine 10:1- 5.
  • Giorgi M, Capocasa F, Scalzo J, Murri G, Battino M, Mezzetti B 2005. The rootstock effects on plant adaptability, production, fruit quality, and nutrition in the peach. Scientia Horticulturae 107: 36-42.
  • Güner M, Kalaycioglu AT, Kanbolat S. orkmaz N, Aliyazicioglu R, Abudayyak M, et al 2019. Evaluation of Antioxidant, Antimicrobial, Antityrosinase and Cytotoxic Potentials of Isatis cappadocica subsp. alyssifoli as a Potent Pharmaceutical Resource. Journal of Pharmaceutical Research International 26: 1-12.
  • Halliwell B and Gutteridge JMC 1999. Free Radicals in Biology and Medicine. In: Halliwell B and Gutteridge JMC, Eds., Free Radicals in Biology and Medicine, 3rd Edition, Oxford University Press, Oxford, 1999:1-25.
  • Hosseinzadeh H, Khooei AR, Khashayarmanesh Z, Motamed-Shariaty V 2010. Antiurolithiatic Activity of Pinus elderica Medw. Fruits Aqueous Extract in Rats. Urology Journal 7: 232-7.
  • Hussain L, Akash MSH, Tahir M, Rehman K, Ahmed KZ 2014. Hepatoprotective Effects of Methanolic Extract of Alcea Rosea Against Acetaminophen-Induced Hepatotoxicity in Mice. Bangladesh Journal of Pharmacology 9:322–327 . https://doi.org/10.3329/bjp.v9i3.19068
  • Kaileh M, Berghe W Vanden, Boone E, Essawi T, Haegeman G 2007. Screening of Indigenous Palestinian Medicinal Plants for Potential Anti-Inflammatory and Cytotoxic Activity. Journal of Ethnopharmacology 113:510– 516. https://doi.org/10.1016/j.jep.2007.07.008
  • Kalemba-Drożdż M, Cierniak A 2019. Antioxidant and Genoprotective Properties of Extracts From Edible Flowers. Journal of Food and Nutrition Research 58:42–50
  • Kamrani Y, Esmaeelian B, Jabbari M, Tabaraei B, Yazdanyar A, Ebrahimi S 2008. Anti-Cancer Effects of Malvidin-3,5-Diglucoside From Alcea Longipedicellata, on Gastric Cancer Cell Line (AGS). Planta Medica 74(9):A174. https://doi.org/10.1055/s-0028-1084172
  • Kasparova S, Brezova V, Valko M 2005. Study of the oxidative stress in a rat model of chronic brain hypoperfusion. Neurochemistry International 46: 601–611.
  • Keser S, Keser F, Tekin S, Kaygili Ö, Turkoglu I, Demir E, Karatepe M, Kirbag S, Yilmaz Ö, Sandal S, Turkoglu S 2020. In vitro Antiradical, Antimicrobial and Antiproliferative Activities and Phytochemical Compositions of Endemic Alcea calvertii (Boiss) Boiss. Flowers 2020. Düzce University Journal of Science & Technology Research 8:693–701. . https://doi.org/10.29130/ dubited.595147
  • Konczak I, Dalar A, Konczak-Islam KA. ‘’Health Attributes, Antioxidant Properties and Phytochemical Composition of Traditional Medicinal Plants from Eastern Anatolia’’, in Medicinal Plants, edt. Pereia D.A.M., Nova Science Publishers, 2014:183 – 225 p. ISBN: 978-1-62948-219-4
  • Kordali Ş, Usanmaz Bozhüyük A, Beyzi E, Güneş A, Turan M 2021. Antioxidant Enzyme, Phenolic Substance and Plant Nutrient Contents of Malva sylvestris L. and Alcea rosea L. Species Used as Medicinal Plants. Journal of the Institute of Science and Technology11:786–794 . https://doi.org/ 10.21597/jist.747673
  • Korkmaz M, Kandemir A, Karacan S 2014. A Surway on Determining The Plant of Taxa Zetrin Spice Ussed in Kemaliye District (Erzincan, Turkey). Bothalia Journal 44: No 3.
  • Korkmaz M, Karakurt E 2014b. Medicinal Plants Sold in Kelkit (Gümüşhane) [Kelkit (Gümüşhane) Aktarlarında Satılan Tıbbi Bitkiler]. Süleyman Demirel University Journal of Natural and Applied Sciences 18: 60-80.
  • Lau CBS, Ho CY, Kim CF, Leunge KN, Fung KP, Tse TF, Chow MSS 2004. Cytotoxic Activities of Coriolus versicolor (Yunzhi) Extract on Human Leukemia and Lymphoma Cells By Induction of Apoptosis. Life Science Journal 75: 797-808.
  • Lee G, Yeom A, Won K, Park CM, Joung MS, Lee GY, CP Jeong 2018. Evaluation of Alcea rosea L. Callus Extract as a Natural Cosmetic Ingredient. Journal of Society of cosmetic scientists of Korea 44:295–302
  • Lyras L, Cairns NJ, Jenner A, Jenner P, Halliwell B 1997. An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer’s disease. Neurochemical Research 68: 2061–2069.
  • Maiti B, Nagori BP, Singh R, Kumar P 2011, Upadhyay N. Recent trends in herbal drugs: a review. The International Journal of Drug Research and Technology1: 17–25.
  • Manach C, Williamson G, Morand C, Scalbert A, Rémésy C 2005. Bioavailability and Bioefficacy of Polyphenols in Humans. I. Review of 97 Bioavailability Studies. The American Journal of Clinical Nutrition 81: 230-242.
  • Marnett LJ 1999. Lipid peroxidation DNA damage by malondialdehyde. Mutation Research 424: 83–95.
  • Mert T, Fafal T, Kivçaks B, Öztürk HT 2010. Antimicrobial and Cytotoxic Activities of The Extracts Obtained From The Flowers of Alcea rosea L. Hacettepe University Journal of the Faculty of Pharmacy 30:17–24
  • Molyneux P 2004. The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin Journal of Science and Technology 26: 211-9.
  • Mombeini T, Behzadi BA, Ejtemaei R, Tahmasbi F, Kamalinejad M, Dehpour AR 2020. Anticonvulsant Effect of Alcea aucheri on Pentylenetetrazole and Maximal Electroshock Seizures in Mice. Basic and Clinical Neuroscience11:369–378 .
  • Mombeini T, Pourbadie HG, Kamalinejad M, Mazloumi S, Dehpour AR 2017. Anxiolytic-Like and Sedative Effects of Alcea aucheri (Boiss.) Alef. Flower Extract in The Laboratory Rat. Iranian Journal of Pharmaceutical Research 16:1495–1508 . https://doi.org/10.22037/ijpr.2017.2142
  • Mossaddegh M, Naghibi F, Moazzeni H, Pirani A, Esmaeili S 2012. Ethnobotanical Surway of Herbal Remedies Traditionally Used in Kohghiluyehva Boyer Ahmad Province of Iran. Journal of Ethnopharmacology 141: 80-96.
  • Pan L, Chai H, Kinghom AD 2010. The Continuing Search for Antitumor Agents From Higher Plants. Phytochemistry Letters 3: 1-8.
  • Qader SW, Abdulla MA, Chua LS 2011. Antioxidant, total phenolic content and cytotoxicity evaluation of selected Malaysian plants. Molecules 16: 3433-3443.
  • Qader SW, Awad HM 2014. Evaluation of Antioxidant, Antimicrobial and Cytotoxicity of Alcea kurdica Alef. Jordan Journal of Biological Sciences 7: 205-209.
  • Sahin Yaglıoglu A, Eser F, Tekin S, Onal A 2016. Antiproliferative Activities of Several Plant Extracts From Turkey on Rat Brain Tumor and Human Cervix Carcinoma Cell Lines. Frontiers in Life Science 9:69–74 . https://doi.org/10.1080/ 21553769.2015.1089949
  • Saravanasingh K, Ramamurthy M, Parthiban P 2016. In-vitro Anti-Urolithiatic Activity of Aerial Parts of Aerva lanata (L.) International Journal of Current Research in Medical Sciences 2: 24-27.
  • Sargin SA 2021. Potential Anti-Influenza Effective Plants Used ın Turkish Folk Medicine: A Review. Journal of Ethnopharmacology 265:113319. https://doi.org/10.1016/j.jep.2020.113319
  • Sayre LM, Smith MA, Perry G 2001. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Current Medicinal Chemistry 8: 721–738.
  • Scalzo J, Politi A, Pellegrini N, Mezzetti B, Battino M 2005. Plant genotype affects total antioxidant capacity and phenolic contents in fruit. Nutrition 21: 207-213.
  • Sener SO, Korkmaz N, Akkaya S, Badem M, Aliyazicioğlu R, Özgen U, et al 2018. Investigation of Phenolic Compounds by RP-HPLC and Antioxidant, Antimicrobial, Tyrosinase Inhibitor Activities of Clinopodium vulgare L. subsp. vulgare Extract. [Clinopodium vulgare L. subsp. vulgare ekstresinin antioksidan, antimikrobial, tirozinaz inhibitor aktiviteleri ve rp-hplc ile fenolik bileşiklerinin araştırılması]. Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi 8: 230-238.
  • Shahabipour F, Caraglia M, Majeed M, Derosa G, Maffioli P, Sahebkar A 2017. Naturally Occurring Anti-Cancer Agents Targeting EZH2. Cancer Letters 400:325–335 . https://doi.org/10.1016/ j.canlet.2017.03.020
  • Singleton VL, Rossi JA 1956. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture 16: 144-58.
  • Turkish Plants Data Service (TÜBİVES), Alcea calvertii. http://www.tubives.com/ , (accessed at March 02, 2020) Tusevski O, Kostovska A, Iloska A 2004. Phenolic production and antioxidant properties of some Macedonian medicinal plants. Central European Journal of Biology 9: 888-900.
  • Unal EL, Mavi A, Kara AA, Cakir A, Şengül M, Yildirim A 2008. Antimicrobial and Antioxidant Activities of Some Plants Used As Remedies in Turkish Traditional Medicine. Pharmaceutical Biology 46:207–224 . https://doi.org/10.1080/ 13880200701735577
  • Uzunhisarcıklı ME, Vural M 2012. The Taxonomic Revision of Alcea and Althaea (Malvaceae) in Turkey. Turkish Journal of Botany 36: 603-639.
  • Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemistry & Biology 160: 1–40.
  • Verschaeve L, Kestens V, Taylor JLS 2004. Investigation of the antimutagenenic effects of selected South African medicinal plant extracts. Toxicology in vitro 18: 29-35.
  • Zakizadeh M, Nabavi SM, Ebrahimzadeh MA 2011. In vitro Antioxidant Activity of Flower Seed and Leaves of Alcea hyrcana Grossh. European Review for Medical and Pharmacological Sciences 15:406–412
  • Zaporozhets OA, Krushynska OA, Lıpkovska NA, Barvınchenko VN 2004. A New Test Method for the Evaluation of Total Antioxidant Activity of Herbal Products. Journal of Agricultural and Food Chemistry 52: 21−25 21

Alcea calvertii'nin Biyolojik Aktivitelerinin İncelenmesi

Year 2022, Volume: 25 Issue: 5, 955 - 964, 31.10.2022

Mahmoud Abudayyak Şeyda Kanbolat Reyyan Ergene Şeyma Batur Rezzan Aliyazıcıoğlu

https://doi.org/10.18016/ksutarimdoga.vi.890659
Cited By: 1

Abstract

Bitkiler ve bitkisel ilaçlar soğuk algınlığı, enfeksiyonlar ve kanser gibi farklı hastalıkların tedavisinde kullanılmaktadır. Alcea calvertii, Malvaceae familyasına ait çok yıllık otsu bir bitkidir. Anadolu ve Akdeniz bölgesinde yayılan bu bitki etnobotanik açısından önemli bir yere sahiptir. Bu çalışmada, Alcea calvertii bitkisinin topraküstü kısımlarının metanol, su, kloroform ve etil asetat ekstrelerinin antioksidan aktiviteleri ile bu ekstrelerin sitotoksik potansiyellerinin incelenmesi amaçlanmıştır. Bu kapsamda, Alcea calvertii’nin antioksidan aktivitesi dört farklı yöntem [toplam fenolik içeriği (TPC), ferrik indirgeyici antioksidan gücü (FRAP), bakır indirgeyici antioksidan kapasitesi (CUPRAC) ve 2,2-difenilpikrilhidrazil (DPPH) radikal süpürme aktivitesini] ile tespit edilmiştir. İnsan akciğer kanseri hücre hattındaki (A549) sitotoksik potansiyeli ise MTT testi ile belirlenmiştir. En yüksek antioksidan aktivitenin metanol ekstresinde olduğu ve artan ekstre konsantrasyonu ile antioksidan aktivitenin arttığı gözlenmiştir; TPC değerlerinin 62,5- 414,6 GAE µg mL-1, FRAP değerlerinin 115,7- 1321,4 µM Trolox eşdeğeri g-1, CUPRAC değerlerinin 177,1 - 1321,4 µM Trolox eşdeğeri g-1, DPPH tespitinde IC50 değerlerinin 0,0089- 3,5370 mg mL-1 arasında hesaplanmıştır. Ekstreler konsantrasyona bağlı olarak hücre ölümüne neden olmuştur ve IC50 değerleri 36,8-62,64 µg mL-1 arasında bulunmuştur. Bu sonuçlar umut verici olup daha kapsamlı çalışmalar ile incelenmesinin önemli olduğu düşünülmektedir.

Keywords

Alcea calvertii Antioksidan Kapasite Sitotoksisite

Project Number

1919B011800561

References

  • Abd El-Salam NM, Radwan MM, Wanas A, Shenouda M, Sallam S, Piacente S, ElSohly M, Ghazy N 2016. Phytochemical And Biological Evaluation of Alcea rosea L., Growing In Egypt. Planta Medica 82:2–3.
  • Abdel-salam NA, Ghazy NM, Sallam SM, Radwan MM, Wanas AS, ElSohly MA, El-Demellawy MA, Abdel-Rahman NM, Piacente S, Shenouda ML 2018. Flavonoids Of Alcea rosea L. And Their Immune Stimulant, Antioxidant and Cytotoxic Activities On Hepatocellular Carcinoma Hepg-2 Cell Line. Natural Product Research 32:702–706.
  • Abudayyak M, Ozdemir Nath E, Ozhan G 2015. Toxic Potentials of Ten Herbs Commonly Used Aphrodisiac Effect in Turkey. Turkish Journal of Medical Sciences 44: 496-506.
  • Ahmadi M, Rad AK, Rajaei Z, Hadjzadeh MAR, Mohammadian N, Tabasi NS 2012. Alcea rosea Root Extract As A Preventive And Curative Agent In Ethylene Glycol-Induced Urolithiasis In Rats. Indian Journal of Pharmacology 44:304–307.
  • Ahmed S, Hasan MM, Mahmood ZA 2016. Antiurolithiatic Plants in Different Countries and Cultures. Journal of Pharmacognosy and Phytochemistry 5: 102-115.
  • Akan H, Bakır Sade Y 2015. Ethnobotanical Investigation of Kahta (Adıyaman) Center and Narince Village [Kahta (Adıyaman) Merkezi ve Narince Köyü’nün Etnobotanik Açıdan Araştırılması] Bitlis Eren University Journal of Science 4(2): 219-248.
  • Alpertunga B, Kara M, Abudayyak M, Oztas E, Ozden S, Özhan G 2014. Effects of prochloraz on DNA damage, lipid peroxidation and antioxidant system in vitro, Toxicology Mechanisms and Methods, 24:4, 268-275
  • Alhage J, Elbitar H 2018. In Vitro Screening for Antioxidant and Antimicrobial Properties of Three Lebanese Medicinal Plants Crude Extracts 2019. Pharmacognosy Research 11(2):127–133.
  • Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, Boyd MR 1988. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Research 48: 589–601.
  • Al-Snafi AE 2013. The Pharmaceutical importance of Althaea officinalis and Althaea rosea: A review. International Journal of PharmTech Research 5:1378–1385
  • Altundag E, Ozturk M 2011. Ethnomedicinal Studies on The Plant Resources of East Anatolia, Turkey. Procedia - Social and Behavioral Sciences 19: 756-777.
  • Anlas C, Ustuner O, Alkan F, Bakirel T, Aydogan M, Erel S 2017. a Comparative Study on the Antioxidant Activities and Phenolic Contents of Different Extracts of a Chillea nobilis Subsp Sipylea and Alcea apterocarpa (Fenzl) Boiss, Endemic Plants in Turkey. Fresenius Environmental Bulletin 26:1423–1430.
  • Apak R, Güçlü K, Ozyürek M, Karademir SE, Erça E 2006. The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas. international journal food science nutrition 57:292-304.
  • Asami S, Manabe H, Miyake J, Tsurudome Y, Hirano T, Yamaguchi R, et al 1997. Cigarette smoking induces an increase in oxidative DNA damage, 8- hydroxydeoxyguanosine, in a central site of the human lung. Carcinogenesis 18:1763–1766.
  • Azab A 2016. Alcea: traditional medicine, current research and future opportunities. European Chemical Bulletin 6 (5): 505-514.
  • Azadeh Z, Saeidi K, Lorigooini Z, Kiani M, Maggi F 2020. Organ-Oriented Phytochemical Profiling and Radical Scavenging Activity of Alcea spp. (Malvaceae) from Iran. SN Applied Sciences 2:1–9. https://doi.org/10.1007/s42452-020-2410-3
  • Beğen HA and Yüksel E 2018. The flora of Alanbaşı and Bakırtepe villages (Yusufeli, Artvin, Turkey) and its surroundings. Turkish Journal of Biodiversity 1:17–23.
  • Benzie IFF, Strain JJ 1996. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Analytical Biochemistry 239: 70-6.
  • Boyzal ME and Mert EM 2018. Antiurolithiatic Activity of Medicinal Plants in Turkey. (Assessment of Working Postures of Nursery Workers in Seedling Production Activities (Ed. Christov I, Strauss E, Gad A, Curebal I) 152-162.
  • Byahatti VV, Vasantakumar Pai K, D’Souza MG 2010. Effect of Phenolic Compound from Bergenia cliata (Haw.) Stemb. Leaves on Experimental Kidney Stones. Ancient science of life 30: 14-17.
  • Chan K 2003. Some aspects of toxic contaminants in herbal medicines, Chemosphere 52: 1361–1371. Dalar A, Mukemre M, Unal M, Ozgokce F 2018. Traditional Medicinal Plants of Ağrı Province, Turkey. Journal of Ethnopharmacology 226:56–72.
  • Dar PA, Ali F, Sheikh IA, Ganie SA, Dar TA 2017. Amelioration of Hyperglycaemia and Modulation of Antioxidant Status By Alcea Rosea Seeds in Alloxan-Induced Diabetic Rats. Pharmaceutical Biology 55:1849–1855 . https://doi.org/10.1080/ 13880209.2017.1333127
  • Dhalla NS, Temsah RM, Netticadan T 2000. Role of oxidative stress in cardiovascular diseases. Journal of Hypertension 18: 655–673.
  • Doğan A, Tuzlacı E 2015. Some Local Plant Names of Tunceli [Tunceli’nin Bazı Yöresel Bitki Adları]. Eurasscience Journal 3: 22-33.
  • Ertas A, Boga M, Gazioglu I, Yesil Y, Hasimi N, Ozaslan C, Yilmaz H, Kaplan M 2016. Fatty acid, Essential Oil and Phenolic Compositions of Alcea Pallida and Alcea apterocarpa With Antioxidant, Anticholinesterase and Antimicrobial Activities. Chiang Mai Journal of Science 43:89–99 .
  • Esmaeili S, Irani M, Zehan HM, Keramatian B, Harandi ZT, Hamzeloo-Moghadam M 2016. Cytotoxic Activity of Some Ethnic Medicinal Plants From Southwest of Iran. Research Journal of Pharmacognosy 3:43–47
  • Fahimi Z, Cheraghi j, Pilehvarian AA, Sayehmiri K, Kjosarvi A 2012. Effects of Alcea angulate Roots Alcoholic Extract on Blood Lipid of Male Rabbit. Journal of Ilam University of medical Sciences 20:23-32.
  • Fahimi Z, Soltanbeigi S, Asadollahi K, Kaffashi M and Kaffashian MR 2018. Effects of Alcoholic Extract of Stem and Aerial Parts of the Alcea angulate Plant on Aorta Atherosclerotic Plaque Formation in Rabbit. Archives of Medicine 10:1- 5.
  • Giorgi M, Capocasa F, Scalzo J, Murri G, Battino M, Mezzetti B 2005. The rootstock effects on plant adaptability, production, fruit quality, and nutrition in the peach. Scientia Horticulturae 107: 36-42.
  • Güner M, Kalaycioglu AT, Kanbolat S. orkmaz N, Aliyazicioglu R, Abudayyak M, et al 2019. Evaluation of Antioxidant, Antimicrobial, Antityrosinase and Cytotoxic Potentials of Isatis cappadocica subsp. alyssifoli as a Potent Pharmaceutical Resource. Journal of Pharmaceutical Research International 26: 1-12.
  • Halliwell B and Gutteridge JMC 1999. Free Radicals in Biology and Medicine. In: Halliwell B and Gutteridge JMC, Eds., Free Radicals in Biology and Medicine, 3rd Edition, Oxford University Press, Oxford, 1999:1-25.
  • Hosseinzadeh H, Khooei AR, Khashayarmanesh Z, Motamed-Shariaty V 2010. Antiurolithiatic Activity of Pinus elderica Medw. Fruits Aqueous Extract in Rats. Urology Journal 7: 232-7.
  • Hussain L, Akash MSH, Tahir M, Rehman K, Ahmed KZ 2014. Hepatoprotective Effects of Methanolic Extract of Alcea Rosea Against Acetaminophen-Induced Hepatotoxicity in Mice. Bangladesh Journal of Pharmacology 9:322–327 . https://doi.org/10.3329/bjp.v9i3.19068
  • Kaileh M, Berghe W Vanden, Boone E, Essawi T, Haegeman G 2007. Screening of Indigenous Palestinian Medicinal Plants for Potential Anti-Inflammatory and Cytotoxic Activity. Journal of Ethnopharmacology 113:510– 516. https://doi.org/10.1016/j.jep.2007.07.008
  • Kalemba-Drożdż M, Cierniak A 2019. Antioxidant and Genoprotective Properties of Extracts From Edible Flowers. Journal of Food and Nutrition Research 58:42–50
  • Kamrani Y, Esmaeelian B, Jabbari M, Tabaraei B, Yazdanyar A, Ebrahimi S 2008. Anti-Cancer Effects of Malvidin-3,5-Diglucoside From Alcea Longipedicellata, on Gastric Cancer Cell Line (AGS). Planta Medica 74(9):A174. https://doi.org/10.1055/s-0028-1084172
  • Kasparova S, Brezova V, Valko M 2005. Study of the oxidative stress in a rat model of chronic brain hypoperfusion. Neurochemistry International 46: 601–611.
  • Keser S, Keser F, Tekin S, Kaygili Ö, Turkoglu I, Demir E, Karatepe M, Kirbag S, Yilmaz Ö, Sandal S, Turkoglu S 2020. In vitro Antiradical, Antimicrobial and Antiproliferative Activities and Phytochemical Compositions of Endemic Alcea calvertii (Boiss) Boiss. Flowers 2020. Düzce University Journal of Science & Technology Research 8:693–701. . https://doi.org/10.29130/ dubited.595147
  • Konczak I, Dalar A, Konczak-Islam KA. ‘’Health Attributes, Antioxidant Properties and Phytochemical Composition of Traditional Medicinal Plants from Eastern Anatolia’’, in Medicinal Plants, edt. Pereia D.A.M., Nova Science Publishers, 2014:183 – 225 p. ISBN: 978-1-62948-219-4
  • Kordali Ş, Usanmaz Bozhüyük A, Beyzi E, Güneş A, Turan M 2021. Antioxidant Enzyme, Phenolic Substance and Plant Nutrient Contents of Malva sylvestris L. and Alcea rosea L. Species Used as Medicinal Plants. Journal of the Institute of Science and Technology11:786–794 . https://doi.org/ 10.21597/jist.747673
  • Korkmaz M, Kandemir A, Karacan S 2014. A Surway on Determining The Plant of Taxa Zetrin Spice Ussed in Kemaliye District (Erzincan, Turkey). Bothalia Journal 44: No 3.
  • Korkmaz M, Karakurt E 2014b. Medicinal Plants Sold in Kelkit (Gümüşhane) [Kelkit (Gümüşhane) Aktarlarında Satılan Tıbbi Bitkiler]. Süleyman Demirel University Journal of Natural and Applied Sciences 18: 60-80.
  • Lau CBS, Ho CY, Kim CF, Leunge KN, Fung KP, Tse TF, Chow MSS 2004. Cytotoxic Activities of Coriolus versicolor (Yunzhi) Extract on Human Leukemia and Lymphoma Cells By Induction of Apoptosis. Life Science Journal 75: 797-808.
  • Lee G, Yeom A, Won K, Park CM, Joung MS, Lee GY, CP Jeong 2018. Evaluation of Alcea rosea L. Callus Extract as a Natural Cosmetic Ingredient. Journal of Society of cosmetic scientists of Korea 44:295–302
  • Lyras L, Cairns NJ, Jenner A, Jenner P, Halliwell B 1997. An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer’s disease. Neurochemical Research 68: 2061–2069.
  • Maiti B, Nagori BP, Singh R, Kumar P 2011, Upadhyay N. Recent trends in herbal drugs: a review. The International Journal of Drug Research and Technology1: 17–25.
  • Manach C, Williamson G, Morand C, Scalbert A, Rémésy C 2005. Bioavailability and Bioefficacy of Polyphenols in Humans. I. Review of 97 Bioavailability Studies. The American Journal of Clinical Nutrition 81: 230-242.
  • Marnett LJ 1999. Lipid peroxidation DNA damage by malondialdehyde. Mutation Research 424: 83–95.
  • Mert T, Fafal T, Kivçaks B, Öztürk HT 2010. Antimicrobial and Cytotoxic Activities of The Extracts Obtained From The Flowers of Alcea rosea L. Hacettepe University Journal of the Faculty of Pharmacy 30:17–24
  • Molyneux P 2004. The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin Journal of Science and Technology 26: 211-9.
  • Mombeini T, Behzadi BA, Ejtemaei R, Tahmasbi F, Kamalinejad M, Dehpour AR 2020. Anticonvulsant Effect of Alcea aucheri on Pentylenetetrazole and Maximal Electroshock Seizures in Mice. Basic and Clinical Neuroscience11:369–378 .
  • Mombeini T, Pourbadie HG, Kamalinejad M, Mazloumi S, Dehpour AR 2017. Anxiolytic-Like and Sedative Effects of Alcea aucheri (Boiss.) Alef. Flower Extract in The Laboratory Rat. Iranian Journal of Pharmaceutical Research 16:1495–1508 . https://doi.org/10.22037/ijpr.2017.2142
  • Mossaddegh M, Naghibi F, Moazzeni H, Pirani A, Esmaeili S 2012. Ethnobotanical Surway of Herbal Remedies Traditionally Used in Kohghiluyehva Boyer Ahmad Province of Iran. Journal of Ethnopharmacology 141: 80-96.
  • Pan L, Chai H, Kinghom AD 2010. The Continuing Search for Antitumor Agents From Higher Plants. Phytochemistry Letters 3: 1-8.
  • Qader SW, Abdulla MA, Chua LS 2011. Antioxidant, total phenolic content and cytotoxicity evaluation of selected Malaysian plants. Molecules 16: 3433-3443.
  • Qader SW, Awad HM 2014. Evaluation of Antioxidant, Antimicrobial and Cytotoxicity of Alcea kurdica Alef. Jordan Journal of Biological Sciences 7: 205-209.
  • Sahin Yaglıoglu A, Eser F, Tekin S, Onal A 2016. Antiproliferative Activities of Several Plant Extracts From Turkey on Rat Brain Tumor and Human Cervix Carcinoma Cell Lines. Frontiers in Life Science 9:69–74 . https://doi.org/10.1080/ 21553769.2015.1089949
  • Saravanasingh K, Ramamurthy M, Parthiban P 2016. In-vitro Anti-Urolithiatic Activity of Aerial Parts of Aerva lanata (L.) International Journal of Current Research in Medical Sciences 2: 24-27.
  • Sargin SA 2021. Potential Anti-Influenza Effective Plants Used ın Turkish Folk Medicine: A Review. Journal of Ethnopharmacology 265:113319. https://doi.org/10.1016/j.jep.2020.113319
  • Sayre LM, Smith MA, Perry G 2001. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Current Medicinal Chemistry 8: 721–738.
  • Scalzo J, Politi A, Pellegrini N, Mezzetti B, Battino M 2005. Plant genotype affects total antioxidant capacity and phenolic contents in fruit. Nutrition 21: 207-213.
  • Sener SO, Korkmaz N, Akkaya S, Badem M, Aliyazicioğlu R, Özgen U, et al 2018. Investigation of Phenolic Compounds by RP-HPLC and Antioxidant, Antimicrobial, Tyrosinase Inhibitor Activities of Clinopodium vulgare L. subsp. vulgare Extract. [Clinopodium vulgare L. subsp. vulgare ekstresinin antioksidan, antimikrobial, tirozinaz inhibitor aktiviteleri ve rp-hplc ile fenolik bileşiklerinin araştırılması]. Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi 8: 230-238.
  • Shahabipour F, Caraglia M, Majeed M, Derosa G, Maffioli P, Sahebkar A 2017. Naturally Occurring Anti-Cancer Agents Targeting EZH2. Cancer Letters 400:325–335 . https://doi.org/10.1016/ j.canlet.2017.03.020
  • Singleton VL, Rossi JA 1956. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture 16: 144-58.
  • Turkish Plants Data Service (TÜBİVES), Alcea calvertii. http://www.tubives.com/ , (accessed at March 02, 2020) Tusevski O, Kostovska A, Iloska A 2004. Phenolic production and antioxidant properties of some Macedonian medicinal plants. Central European Journal of Biology 9: 888-900.
  • Unal EL, Mavi A, Kara AA, Cakir A, Şengül M, Yildirim A 2008. Antimicrobial and Antioxidant Activities of Some Plants Used As Remedies in Turkish Traditional Medicine. Pharmaceutical Biology 46:207–224 . https://doi.org/10.1080/ 13880200701735577
  • Uzunhisarcıklı ME, Vural M 2012. The Taxonomic Revision of Alcea and Althaea (Malvaceae) in Turkey. Turkish Journal of Botany 36: 603-639.
  • Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemistry & Biology 160: 1–40.
  • Verschaeve L, Kestens V, Taylor JLS 2004. Investigation of the antimutagenenic effects of selected South African medicinal plant extracts. Toxicology in vitro 18: 29-35.
  • Zakizadeh M, Nabavi SM, Ebrahimzadeh MA 2011. In vitro Antioxidant Activity of Flower Seed and Leaves of Alcea hyrcana Grossh. European Review for Medical and Pharmacological Sciences 15:406–412
  • Zaporozhets OA, Krushynska OA, Lıpkovska NA, Barvınchenko VN 2004. A New Test Method for the Evaluation of Total Antioxidant Activity of Herbal Products. Journal of Agricultural and Food Chemistry 52: 21−25 21
There are 71 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section RESEARCH ARTICLE
Authors

Mahmoud Abudayyak 0000-0003-2286-4777

Şeyda Kanbolat 0000-0001-7261-7067

Reyyan Ergene 0000-0003-4985-9812

Şeyma Batur 0000-0003-0934-0223

Rezzan Aliyazıcıoğlu 0000-0003-0143-8795

Project Number 1919B011800561
Publication Date October 31, 2022
Submission Date March 13, 2021
Acceptance Date October 28, 2021
Published in Issue Year 2022Volume: 25 Issue: 5

Cite

APA Abudayyak, M., Kanbolat, Ş., Ergene, R., Batur, Ş., et al. (2022). Investigation of the Biological Activities of Alcea calvertii. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 25(5), 955-964. https://doi.org/10.18016/ksutarimdoga.vi.890659

Cited By

Comparison of Antioxidant Activity, Metal Chelating Power and Antibacterial Activity in Different Tissues of Alcea calvertii (Boiss.) Boiss.
Bitlis Eren Üniversitesi Fen Bilimleri Dergisi
https://doi.org/10.17798/bitlisfen.1349138
 Download Cover Image


International Peer Reviewed Journal
Free submission and publication
Published 6 times a year



88x31.png


KSU Journal of Agriculture and Nature

e-ISSN: 2619-9149