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D Vitamini Düzeyi ile Kan Eozinofil Sayısı Arasındaki İlişki

Yıl 2022, Cilt: 31 Sayı: 1, 43 - 49, 11.03.2022
https://doi.org/10.17942/sted.1066260

Öz

Amaç: Bu çalışma serum 25(OH)D3 düzeyiyle kan eozinofil sayısı arasındaki ilişkisi değerlendirmek amacıyla yapıldı.
Yöntem: Ocak 2020-Aralık 2021 tarihleri arasında Dahiliye Polikliniğine başvuran hastalar retrospektif olarak değerlendirildi. Eş zamanlı serum 25(OH)D3 vitamin düzeyi ile tam kan sayımı bakılan 1424 hasta alındı. Hastalar 25(OH)D3 düzeyine göre gruplara ayrıldı. Gruplar arasında tam kan parametreleri karşılaştırıldı.
Bulgular: Hastaların ortalama yaşı 39,17±15,74 olup, 1133’ü (%79,6) kadın idi. Tüm hastaların ortalama D vitamini düzeyi 16,79±12,58 ng/mL olarak tespit edildi. Hastaların %69,5’inde D vitamini eksikliği, %19,1’inde D vitamini yetersizliği saptandı. Gruplar, eozinofil sayısına göre karşılaştırıldı. D vitamini eksik olan Grup 1’de eozinofil sayısı, D vitamini yetersiz olan Grup 2 ve D vitamini yeterli olan Grup 3’e göre anlamlı daha yüksek saptandı (sırasıyla p:0.011 ve p:0.008). Grup 2’de, Grup 3’e göre eozinofil sayısı anlamlı daha yüksekti (p:0.014).
Sonuç: D vitamini eksikliğinin daha yüksek kan eozinofil sayısı ile ilişkili olduğunu tespit ettik. D vitamini takviyesinin alerjik inflamasyonda görevli olan eozinofillerin kandaki düzeylerini düşürmeye, dolayısıyla alerjik hastalıkların başlama ve alevlenmesine karşı koruyucu olabileceğini düşünmekteyiz.

Kaynakça

  • Holick MF. Vitamin D: evolutionary, physiological and health perspectives. Curr Drug Targets 2011; 12: 4-18.
  • Özdemir Ö, Karavaizoğlu Ç. Role and Importance of Vitamin D in Asthma and Other Allergic Diaseases. DOI: 10.5152 JAREM 2018; 8: 1-8.
  • Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM. Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Ann N Y Acad Sci 2014; 1317: pp. 57-69.
  • Southo Filho JTD, Andre AS, Riberio FM, Sardenberg Alves PA, Simonini VRF. Impact of vitamin D deficiency on increased blood eosinophil count. Hematol Oncol Stem Cell Ther. 2018 Mar;11(1):25-29.
  • Mirzakhani H, Al-Garawi A, Weiss ST, Litonjua AA. Vitamin D and the development of allergic disease: how important is it?. Clin Exp Allergy 2015; 45: pp. 114-125.
  • Zeyrek CD, Zeyrek F, Sevinc E, Demir E. Prevalence of asthma and allergic diseases in Sanliurfa, Turkey, and the relation to environmental and socioeconomic factors: is the hygiene hypothesis enough? J Investig Allergol Clin Immunol. 2006;16:290–295.
  • Spencer LA, Weller PF. Eosinophils and Th2 immunity: contemporary insights. Immunol Cell Biol 2010; 88: pp. 250-256.
  • Gogas Yavuz D. Vitamin D eksikliği. Osteoporoz ve Metabolik Kemik Hastalıkları Tanı ve Tedavi Kılavuzu. Türkiye Endokrinoloji ve Metabolizma Derneği. 2019. 119-127.
  • Braegger C, Campoy C, Colomb V, et al. Vitamin D in healthy European paediatric population. JPGN 2013;56:692-701.
  • Demiral M, Sırmagül B, Kırel B. Endokrin polikliniğine başvuran çocuklarda D vitamini düzeyleri. J Curr Pediatr. 2016;14:60-6.
  • Taşkıran B, Cansu GB. Güneydoğu bölgesinde erişkinlerde D vitamini eksikliği. Osmangazi Journal of Medicine 2016;39:13-20. Çocuk Dergisi 2018;18(3): 102.
  • Cashman KD, Dowling KG, Skrabakova Z, et al. Vitamin D deficiency in Europa: pandemic? Am J Clin Nutr. 2016;103:1033-44.
  • Börekci ÖN. Current information on vitamin D deficiency. Jour Turk Fam Phy 2019; 10 (1): 35-42.
  • Cigerli O, Parıldar H, Unal AD, Tarcin O, Erdal R, Demirag NG. Vitamin D deficiency is a problem for adult out-patients? A university hospital sample in Istanbul, Turkey. Public Health Nutr. 2013 Jul;16(7):1306-13.
  • Karatas S, Hacıoğlu Y, Köse S. Vitamin D Deficiency and Microalbuminuria in Patients with Diabetes Mellitus. Turk J Diab Obes 2021;3: 265-269.
  • Holick MF. Vitamin D: a D-lightful health perspective. Nutr Rev 2008;66:182-94.
  • Hyppönen E, Boucher BJ, Berry DJ, Power C. 25-hydroxyvitamin D, IGF-1, and metabolic syndrom at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes 2008;57:298-305.
  • Yepes-Nunez JJ, Fiocchi A, Pawankar R, Cuello-Garcia CA, Zhang Y, Morgano GP, et al. World Allergy Organization- McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Vitamin D, World Allergy Organ J. 9 (2016) 17.
  • Brehm JM, Celedon JC, Soto-Quiros ME, Avila L, Hunninghake GM, Forno E, et. al.: Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med 2009; 179: pp. 765-7.
  • Ozkars MY, Keskin O, Küçükosmanoglu E, Ulusal H, Orkme M. Astımlı Olgularımızda D Vitamini Kullanımı ile Astım Kontrolünün Değerlendirilmesi. Zeynep Kamil Tıp Bülteni;2017;48(4):142-145.
  • Al-Thagfan SS, Alolayan SO, Ahmed S, Emara MM, Awadallah MF. Impacts of deficiency in vitamin D derivatives on disease severity in adult bronchial asthma patients. Pulm Pharmacol Ther. 2021 Oct;70:102073.
  • Montero-Arias F, Sedo-Mejia G, Ramos-Esquivel A. Vitamin D insufficiency and asthma severity in adults from Costa Rica. Allergy Asthma Immunol Res 2013; 5: pp. 283-288.
  • Krobtrakulchai W, Praikanahok J, Visitsunthorn N, Vichyanond P, Manonukul K, Pratumvinit B, et. al.: The effect of vitamin D status on pediatric asthma at a university hospital, Thailand. Allergy Asthma Immunol Res 2013; 5: pp. 289-294.
  • de Groot JC, van Roon EN, Storm H, Veeger NJ, Zwinderman AH, Hiemstra PS, et. al. Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma. J Allergy Clin Immunol 2015; 135: pp. 670-675.

The Relationship Between Vitamin D Level and Blood Eosinophil Counts

Yıl 2022, Cilt: 31 Sayı: 1, 43 - 49, 11.03.2022
https://doi.org/10.17942/sted.1066260

Öz

Objective: This study was conducted to evaluate the relationship between serum 25(OH)D3 level and blood eosinophil count.
Methods: Patients admitted to the Internal Medicine outpatient clinic between January 2020 and December 2021 were evaluated retrospectively. A total of 1424 patients whose serum 25(OH)D3 vitamin levels and complete blood count were measured simultaneously were included. Patients were divided into groups according to 25(OH)D3 levels. Whole blood parameters were compared between the groups.
Results: The mean age of the patients was 39.17±15.74 years, of which 1133 (79.6%) were female. The mean vitamin D level of all patients was found to be 16.79±12.58 ng/mL. Vitamin D deficient was found in 69.5% of the patients, and vitamin D insufficient was found in 19.1% of the patients. The groups were compared according to the eosinophil count. The eosinophil count was found to be significantly higher in Group 1 with vitamin D deficient than in Group 2 with vitamin D insufficient and Group 3 with sufficient vitamin D (p:0.011 and p:0.008, respectively). Eosinophil count was significantly higher in Group 2 than in Group 3 (p:0.014).
Conclusion: We found that vitamin D deficient was associated with higher blood eosinophil count. We think that vitamin D supplementation may be protective against the onset and exacerbation of allergic diseases, by reducing the blood levels of eosinophils, which are responsible for allergic inflammation.

Kaynakça

  • Holick MF. Vitamin D: evolutionary, physiological and health perspectives. Curr Drug Targets 2011; 12: 4-18.
  • Özdemir Ö, Karavaizoğlu Ç. Role and Importance of Vitamin D in Asthma and Other Allergic Diaseases. DOI: 10.5152 JAREM 2018; 8: 1-8.
  • Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM. Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Ann N Y Acad Sci 2014; 1317: pp. 57-69.
  • Southo Filho JTD, Andre AS, Riberio FM, Sardenberg Alves PA, Simonini VRF. Impact of vitamin D deficiency on increased blood eosinophil count. Hematol Oncol Stem Cell Ther. 2018 Mar;11(1):25-29.
  • Mirzakhani H, Al-Garawi A, Weiss ST, Litonjua AA. Vitamin D and the development of allergic disease: how important is it?. Clin Exp Allergy 2015; 45: pp. 114-125.
  • Zeyrek CD, Zeyrek F, Sevinc E, Demir E. Prevalence of asthma and allergic diseases in Sanliurfa, Turkey, and the relation to environmental and socioeconomic factors: is the hygiene hypothesis enough? J Investig Allergol Clin Immunol. 2006;16:290–295.
  • Spencer LA, Weller PF. Eosinophils and Th2 immunity: contemporary insights. Immunol Cell Biol 2010; 88: pp. 250-256.
  • Gogas Yavuz D. Vitamin D eksikliği. Osteoporoz ve Metabolik Kemik Hastalıkları Tanı ve Tedavi Kılavuzu. Türkiye Endokrinoloji ve Metabolizma Derneği. 2019. 119-127.
  • Braegger C, Campoy C, Colomb V, et al. Vitamin D in healthy European paediatric population. JPGN 2013;56:692-701.
  • Demiral M, Sırmagül B, Kırel B. Endokrin polikliniğine başvuran çocuklarda D vitamini düzeyleri. J Curr Pediatr. 2016;14:60-6.
  • Taşkıran B, Cansu GB. Güneydoğu bölgesinde erişkinlerde D vitamini eksikliği. Osmangazi Journal of Medicine 2016;39:13-20. Çocuk Dergisi 2018;18(3): 102.
  • Cashman KD, Dowling KG, Skrabakova Z, et al. Vitamin D deficiency in Europa: pandemic? Am J Clin Nutr. 2016;103:1033-44.
  • Börekci ÖN. Current information on vitamin D deficiency. Jour Turk Fam Phy 2019; 10 (1): 35-42.
  • Cigerli O, Parıldar H, Unal AD, Tarcin O, Erdal R, Demirag NG. Vitamin D deficiency is a problem for adult out-patients? A university hospital sample in Istanbul, Turkey. Public Health Nutr. 2013 Jul;16(7):1306-13.
  • Karatas S, Hacıoğlu Y, Köse S. Vitamin D Deficiency and Microalbuminuria in Patients with Diabetes Mellitus. Turk J Diab Obes 2021;3: 265-269.
  • Holick MF. Vitamin D: a D-lightful health perspective. Nutr Rev 2008;66:182-94.
  • Hyppönen E, Boucher BJ, Berry DJ, Power C. 25-hydroxyvitamin D, IGF-1, and metabolic syndrom at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes 2008;57:298-305.
  • Yepes-Nunez JJ, Fiocchi A, Pawankar R, Cuello-Garcia CA, Zhang Y, Morgano GP, et al. World Allergy Organization- McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Vitamin D, World Allergy Organ J. 9 (2016) 17.
  • Brehm JM, Celedon JC, Soto-Quiros ME, Avila L, Hunninghake GM, Forno E, et. al.: Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med 2009; 179: pp. 765-7.
  • Ozkars MY, Keskin O, Küçükosmanoglu E, Ulusal H, Orkme M. Astımlı Olgularımızda D Vitamini Kullanımı ile Astım Kontrolünün Değerlendirilmesi. Zeynep Kamil Tıp Bülteni;2017;48(4):142-145.
  • Al-Thagfan SS, Alolayan SO, Ahmed S, Emara MM, Awadallah MF. Impacts of deficiency in vitamin D derivatives on disease severity in adult bronchial asthma patients. Pulm Pharmacol Ther. 2021 Oct;70:102073.
  • Montero-Arias F, Sedo-Mejia G, Ramos-Esquivel A. Vitamin D insufficiency and asthma severity in adults from Costa Rica. Allergy Asthma Immunol Res 2013; 5: pp. 283-288.
  • Krobtrakulchai W, Praikanahok J, Visitsunthorn N, Vichyanond P, Manonukul K, Pratumvinit B, et. al.: The effect of vitamin D status on pediatric asthma at a university hospital, Thailand. Allergy Asthma Immunol Res 2013; 5: pp. 289-294.
  • de Groot JC, van Roon EN, Storm H, Veeger NJ, Zwinderman AH, Hiemstra PS, et. al. Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma. J Allergy Clin Immunol 2015; 135: pp. 670-675.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Orjinal Araştırma
Yazarlar

Fatma Yılmaz Aydın 0000-0002-8101-2497

Şengül Baran Yerlikaya Bu kişi benim 0000-0001-9624-8091

Erken Görünüm Tarihi 11 Mart 2022
Yayımlanma Tarihi 11 Mart 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 31 Sayı: 1

Kaynak Göster

Vancouver Yılmaz Aydın F, Baran Yerlikaya Ş. D Vitamini Düzeyi ile Kan Eozinofil Sayısı Arasındaki İlişki. STED. 2022;31(1):43-9.