Konya ilinde sağlıklı bireylerin demografik özelliklerine ve antropometrik ölçümlerine göre lipid düzeylerinin değerlendirilmesi
Öz
Amaç: Bu çalışmada Konya ilinde iç hastalıkları polikliniklerimize başvuran sağlıklı bireylerin serum lipid değerlerinin belirlenmesi, bu değerlerin yaş gruplarına göre karşılaştırılması, demografik faktörler, antropometrik ölçümlerle ilişkilerinin gösterilmesi amaçlanmıştır.
Gereç ve Yöntem: İç hastalıkları polikliniklerine başvuran 18 yaş üzeri 200 sağlıklı birey çalışmaya dahil edildi. Bu kişilerin antropometrik ölçümleri yapılarak demografik özellikleri sorgulandı. Ayrıca bu kişilerden periferik kan örneği alınarak total kolesterol(TK), düşük dansiteli lipoprotein kolesterol(LDL), trigliserid(TG), yüksek dansiteli lipoprotein kolesterol(HDL), Apolipoprotein A-1(Apo A-1), Apolipoprotein B(Apo B) ve lipoprotein (a) düzeyleri çalışıldı.
Bulgular: Çalışmamıza 123 kadın ve 77 erkek olmak üzere 200 gönüllü sağlıklı birey katıldı. TK düzeyi 183 ± 40 mg/dl, LDL düzeyi 112 ± 34 mg/dl, TG düzeyi 112 ± 61 mg/dl, HDL düzeyi 47 ± 11 mg/dl, Apo A-1 düzeyi 133 ± 22 mg/dl, Apo B düzeyi 79 ± 22 mg/dl, Lp(a) düzeyi 19 ± 12 mg/dl olarak ölçüldü. TK/HDL oranı 4.1 ± 1.3 olarak bulundu. HDL ve Apo B düzeyleri kadınlarda, TG ve TK/HDL oranı ise erkeklerde anlamlı oranda yüksek bulundu. Katılımcıların % 31’inde hiperkolesterolemi (≥200 mg/dl), % 27’sinde LDL yüksekliği (≥130 mg/dl) vardı. Total kolesterol, LDL, TG, Apo B değerleri yaşla beraber artış göstermekteydi.
Sonuç: Türkiye’de yapılan geniş kapsamlı çalışmalarla karşılaştırdığımızda daha düşük TK, LDL, TG ve daha yüksek HDL düzeyleri saptadık.
Anahtar Kelimeler
Kaynakça
- 1- Laslett LJ, Alagona P Jr, Clark BA,3rd, Drozda JP Jr, Saldivar F, Wilson SR, et al. The worldwide environment of cardiovascular disease: Prevalence, diagnosis, therapy, and policy issues: A report from the american college of cardiology. J Am Coll Cardiol 2012;60:1-49.
- 2- World Health Organization. The Atlas of Heart Disease and Stroke. Part 2 Risk factors. (accessed 12 December 2011). Available from: URL: http:/www.int/cardiovasculardiseases/resources/atlas/en
- 3- Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation 1998;97:1837-47.
- 4- Hong YM. Atherosclerotic cardiovascular disease beginning in childhood. Korean Circ J 2010;40:1-9.
- 5- Badimon L, Vilahur G. LDL-cholesterol versus HDL-cholesterol in the atherosclerotic plaque: inflammatory resolution versus thrombotic chaos. Ann N Y Acad Sci 2012;1254:18-32.
- 6- Onat A. Halkımızın total kolesterol düzeyi normal üst sınırı neden mutlaka 180 mg/dl’ye çekilmeli? Türk Kardiyol Dern Arş 2001;29:703-7.
- 7- Onat A, Surdum-Avcı G, Senocak M, Ornek E .Gozukara Y. Plasma lipids and their interrelationship in Turkish adults. J Epidemiol Community Health 1992;46:470-6.
- 8- Mahley RW, Palaoğlu KE, Atak Z, Dawson-Pepin J, Langlois AM, Cheung V, et al. Turkish Heart Study: lipids, lipoproteins, and apolipoproteins. J Lipid Res 1995;36:839-59.
- 9- Onat A. Lipids, lipoproteins and apolipoproteins among turks, and impact on coronary heart disease. Anadolu Kardiyol Derg 2004;4:236-45.
- 10- Adam B, Talu C, Bedir A, Alvur M, Sağkan O. The levels of lipids, lipoproteins and apolipoproteins in healthy people in the central region of the Black Sea. Jpn Heart J 1999;40:427-34.
- 11- Erem C, Hacıhasanoglu A, Deger O, Kocak M, Topbas M. Prevalence of dyslipidemia and associated risk factors among Turkish adults: Trabzon lipid study. Endocrine 2008;34:36-51.
- 12- Bayram F, Kocer D, Gundogan K, Kaya A, Demir O, Coskun R, et al. Prevalence of dyslipidemia and associated risk factors in Turkish adults. J Clin Lipidol 2014;8:206-16.
- 13- Luttmann S, von Eckardstein A, Wei W, Funke H, Köhler E, Mahley RW, et al. Electrophoretic screening for genetic variation in apolipoprotein C-III: identification of a novel apoC-III variant, apoC-III(Asp45-->Asn), in a Turkish patient. J Lipid Res 1994;35:1431-40.
- 14- Onat A, Yıldırım B, Uslu N, Gurbuz N, Keles I, Cetinkaya A, et al. Türk erişkinlerinde plazma lipoprotein ve apolipoproteinleri: Genel düzeyler, risk faktörleriyle ilişkileri ve kadınlarda HDL’nin koroner riski belirleyiciliği. Türk Kardiyol Dern Arş 1999;27:72-9.
- 15- Grabauskas V, Miseviciene I, Klumbiene J, Petkeviciene J, Milasauskiene Z, Plieskiene A, et al. Prevalence of dyslipidemias among Lithuanian rural population (CINDI program). Medicina (Kaunas) 2003;39:1215-22.
- 16- Yarnell J, Yu S, McCrum E, Arveiler D, Hass B, Dallongeville J, et al. Education, socioeconomic and lifestyle factors, and risk of coronary heart disease: the PRIME Study. Int J Epidemiol 2005;34:268-75.
- 17- Kazeminasab F, Marandi M, Ghaedi K, Esfarjani F, Moshtaghian J. Endurance training enhances LXRα gene expression in Wistar male rats. Eur J Appl Physiol 2013;113:2285-90.
- 18- Yalın S,Gök H, Toksöz R. The effects of the short-term regular exercise-diet program on lipid profile in sedentary subjects. Anadolu Kardiyol Derg 2001;1:179-8.
- 19- Graner M, Siren R, Nyman K, Lundbom J, Hakkarainen A, Pentikäinen MO, et al. Cardiac steatosis associates with visceral obesity in nondiabetic obese men. J Clin Endocrinol Metab 2013;98:1189-97.
- 20- Smith U. Abdominal obesity: a marker of ectopic fat accumulation. J Clin Invest 2015;125:1790-2.
- 21- Aswathappa J, Garg S, Kutty K, Shankar V. Neck circumference as an anthropometric measure of obesity in diabetics. N Am J Med Sci 2013;5:28-31.
- 22- Onat A, Hergenç G, Yüksel H, Can G, Ayhan E, Kaya Z, et al. Neck circumference as a measure of central obesity: associations with metabolic syndrome and obstructive sleep apnea syndrome beyond waist circumference. Clin Nutr 2009;28:46-51.
- 23- Aksu F, Topaçoğlu H, Arman C, Ataç A, Tetik S. Neck circumference and 2:4 digit ratio in patients with acute myocardial infarction. Türkiye Klinikleri J Cardiovasc Sci 2009;21:147-52.
- 24- Ceylan E, Ege E. Obstrüktif Uyku Apnesi Sendromu Etyolojisi ve Risk Faktörleri: Obezite ve diğer risk faktörleri. Türkiye Klinikleri J Surg Med Sci 2007;3:28-33.
Evaluation of lipid levels according to demographic characteristics and anthropometric measurements of healthy individuals in Konya province
Öz
Purpose: The aim of this study was to determine serum lipid values of healthy individuals who applied to our internal medicine outpatient clinics in Konya and to compare these values with demographic factors and to show their relationship with anthropometric measurements.
Materials and Methods: A total of 200 healthy individuals over 18 years of age who applied to internal medicine outpatient clinics were included in the study. Their anthropometric measurements were performed and their demographic characteristics were questioned. In addition, total cholesterol(TC), low density lipoprotein(LDL), triglyceride(TG), high density lipoprotein(HDL), apolipoprotein A-1(Apo A-1), apolipoprotein B(Apo B) and lipoprotein (a) levels were studied from their blood samples.
Results: Two hundred healthy volunteers, including 123 women and 77 men were participated in our study. TC levels were 183 ± 40 mg/dl, LDL level 112 ± 34 mg/dl, TG level 112 ± 61 mg/dl, HDL level 47 ± 11 mg/dl, Apo A-1 level 133 ± 22 mg/dl, Apo B level 79 ± 22 mg/dl Lp(a) level 19 ± 12 mg/dl. HDL and Apo B levels were higher in women however TG and TC/HDL ratio was significantly higher in males. Thirty one percent of participants had hypercholesterolemia (≥200 mg/dl), 27% had increased levels of LDL (≥130 mg/dl). TK, LDL and Apo B levels were significantly increasing with age. Conclusion: When we compared the extensive studies which were carried out in Turkey, lower TC, LDL, TG and higer HDL levels were detected in our study.
Anahtar Kelimeler
Lipid levels anthropometric measurement demographic characteristics healthy volunteers
Kaynakça
- 1- Laslett LJ, Alagona P Jr, Clark BA,3rd, Drozda JP Jr, Saldivar F, Wilson SR, et al. The worldwide environment of cardiovascular disease: Prevalence, diagnosis, therapy, and policy issues: A report from the american college of cardiology. J Am Coll Cardiol 2012;60:1-49.
- 2- World Health Organization. The Atlas of Heart Disease and Stroke. Part 2 Risk factors. (accessed 12 December 2011). Available from: URL: http:/www.int/cardiovasculardiseases/resources/atlas/en
- 3- Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation 1998;97:1837-47.
- 4- Hong YM. Atherosclerotic cardiovascular disease beginning in childhood. Korean Circ J 2010;40:1-9.
- 5- Badimon L, Vilahur G. LDL-cholesterol versus HDL-cholesterol in the atherosclerotic plaque: inflammatory resolution versus thrombotic chaos. Ann N Y Acad Sci 2012;1254:18-32.
- 6- Onat A. Halkımızın total kolesterol düzeyi normal üst sınırı neden mutlaka 180 mg/dl’ye çekilmeli? Türk Kardiyol Dern Arş 2001;29:703-7.
- 7- Onat A, Surdum-Avcı G, Senocak M, Ornek E .Gozukara Y. Plasma lipids and their interrelationship in Turkish adults. J Epidemiol Community Health 1992;46:470-6.
- 8- Mahley RW, Palaoğlu KE, Atak Z, Dawson-Pepin J, Langlois AM, Cheung V, et al. Turkish Heart Study: lipids, lipoproteins, and apolipoproteins. J Lipid Res 1995;36:839-59.
- 9- Onat A. Lipids, lipoproteins and apolipoproteins among turks, and impact on coronary heart disease. Anadolu Kardiyol Derg 2004;4:236-45.
- 10- Adam B, Talu C, Bedir A, Alvur M, Sağkan O. The levels of lipids, lipoproteins and apolipoproteins in healthy people in the central region of the Black Sea. Jpn Heart J 1999;40:427-34.
- 11- Erem C, Hacıhasanoglu A, Deger O, Kocak M, Topbas M. Prevalence of dyslipidemia and associated risk factors among Turkish adults: Trabzon lipid study. Endocrine 2008;34:36-51.
- 12- Bayram F, Kocer D, Gundogan K, Kaya A, Demir O, Coskun R, et al. Prevalence of dyslipidemia and associated risk factors in Turkish adults. J Clin Lipidol 2014;8:206-16.
- 13- Luttmann S, von Eckardstein A, Wei W, Funke H, Köhler E, Mahley RW, et al. Electrophoretic screening for genetic variation in apolipoprotein C-III: identification of a novel apoC-III variant, apoC-III(Asp45-->Asn), in a Turkish patient. J Lipid Res 1994;35:1431-40.
- 14- Onat A, Yıldırım B, Uslu N, Gurbuz N, Keles I, Cetinkaya A, et al. Türk erişkinlerinde plazma lipoprotein ve apolipoproteinleri: Genel düzeyler, risk faktörleriyle ilişkileri ve kadınlarda HDL’nin koroner riski belirleyiciliği. Türk Kardiyol Dern Arş 1999;27:72-9.
- 15- Grabauskas V, Miseviciene I, Klumbiene J, Petkeviciene J, Milasauskiene Z, Plieskiene A, et al. Prevalence of dyslipidemias among Lithuanian rural population (CINDI program). Medicina (Kaunas) 2003;39:1215-22.
- 16- Yarnell J, Yu S, McCrum E, Arveiler D, Hass B, Dallongeville J, et al. Education, socioeconomic and lifestyle factors, and risk of coronary heart disease: the PRIME Study. Int J Epidemiol 2005;34:268-75.
- 17- Kazeminasab F, Marandi M, Ghaedi K, Esfarjani F, Moshtaghian J. Endurance training enhances LXRα gene expression in Wistar male rats. Eur J Appl Physiol 2013;113:2285-90.
- 18- Yalın S,Gök H, Toksöz R. The effects of the short-term regular exercise-diet program on lipid profile in sedentary subjects. Anadolu Kardiyol Derg 2001;1:179-8.
- 19- Graner M, Siren R, Nyman K, Lundbom J, Hakkarainen A, Pentikäinen MO, et al. Cardiac steatosis associates with visceral obesity in nondiabetic obese men. J Clin Endocrinol Metab 2013;98:1189-97.
- 20- Smith U. Abdominal obesity: a marker of ectopic fat accumulation. J Clin Invest 2015;125:1790-2.
- 21- Aswathappa J, Garg S, Kutty K, Shankar V. Neck circumference as an anthropometric measure of obesity in diabetics. N Am J Med Sci 2013;5:28-31.
- 22- Onat A, Hergenç G, Yüksel H, Can G, Ayhan E, Kaya Z, et al. Neck circumference as a measure of central obesity: associations with metabolic syndrome and obstructive sleep apnea syndrome beyond waist circumference. Clin Nutr 2009;28:46-51.
- 23- Aksu F, Topaçoğlu H, Arman C, Ataç A, Tetik S. Neck circumference and 2:4 digit ratio in patients with acute myocardial infarction. Türkiye Klinikleri J Cardiovasc Sci 2009;21:147-52.
- 24- Ceylan E, Ege E. Obstrüktif Uyku Apnesi Sendromu Etyolojisi ve Risk Faktörleri: Obezite ve diğer risk faktörleri. Türkiye Klinikleri J Surg Med Sci 2007;3:28-33.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Araştırma |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Eylül 2019 |
| Kabul Tarihi | 19 Şubat 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 44 Sayı: 3 |
