Clastogenic effect of sodium arsenite in experimental rats and ameliorative effects of antioxidant vitamins C and E

B S  Balakumar; S  Kumaresan; R Venugopal  and V  Sivasubramanian

doi:10.17485/ijst/2010/v3i6.22

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Clastogenic effect of sodium arsenite in experimental rats and ameliorative effects of antioxidant vitamins C and E

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Indian Journal of Science and Technology

DOI: 10.17485/ijst/2010/v3i6.22

Year: 2010, Volume: 3, Issue: 6, Pages: 642-647

Original Article

Clastogenic effect of sodium arsenite in experimental rats and ameliorative effects of antioxidant vitamins C and E

B.S. Balakumar¹ , S. Kumaresan¹ , R.Venugopal² and V. Sivasubramanian^1*

¹ Department of Plant Biology & Plant Biotechnology, RKM. Vivekananda College, Mylapore, Chennai -600 004, India
² Research Institute of Veterinary Medicine, Chungbuk National University, South Korea
[email protected]

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Arsenic, an element ubiquitous in the environment, causes serious health problems in humans. The general population is more exposed to arsenic through drinking water than through air and food. Sodium arsenite, capable of inducing genotoxic effects through oxidative stress, is evaluated for its clastogenic effect by the formation of chromosomal aberrations in the bone marrow cells of Wistar rats. We also investigated whether the oral supplementation of α– tocopherol (400 mg/kg body weight) and ascorbic acid (200 mg/kg body weight) to arsenic–intoxicated rats (100 ppm in drinking water) for 30days, ameliorates arsenic-induced toxicity. We report that the dietary supplementation of antioxidants such as vitamins C and E could prevent sodium arsenite induced toxicity in rats under experimental conditions.
Keywords: Arsenic, genotoxicity, ascorbic acid, α-tocopherol, chromosomal aberrations, vitamins, rat, bone marrow.