Abstract
Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis. The following contributions are made: (1) we comprehensively describe the expression profile, competing endogenous RNA (ceRNA) network, and “pre-necrotic” biomarkers of non-exo/exo-ncRNAs for MI; (2) functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress, etc.; (3) we propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, thereby providing a theoretical basis for the clinical management of MI.
摘要
非外泌体/外泌体非编码RNAs与心肌梗死(MI)的病理发展相关。本文对目前血浆中非外泌体/外泌体非编码RNAs在MI中的作用进行了概述,总结了上述非编码RNAs的特点和关键作用,并通过生物信息学分析揭示其新的生物学关联性,内容包括:(1)全面描述了MI中非外泌体/外泌体非编码RNAs的表达、内源竞争RNA网络和“坏死前”的生物标志物;(2)分析证实非编码RNAs的靶基因在调控细胞凋亡信号通路和细胞对化学应激反应等过程中富集;(3)对非外泌体/外泌体非编码RNAs在MI中的调节机制、病理生理学功能和作为生物标志物方面的作用提出了新的视角,为其临床治疗提供理论依据。
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Acknowledgments
This work was supported by the National Natural Science Foundation of China (Nos. 81860073, 81760074, and 82160439), the Yunnan Provincial Department of Science and Technology (No. 202001AT070039), the Yunnan Health Training Project of High-Level Talents (No. H-2018032), the 100 Young and Middle-aged Academic and Technical Backbones of Kunming Medical University (No. 60118260106), the Young Talents of Yunnan Thousand Talents Plan (Nos. YNQR-QNRC-2019-006 and RLQN20200002), the Graduate Student Innovation Fund of Kunming Medical University (No. 2022S035), and the Clinical Medical Center for Cardiovascular and Cerebrovascular Disease of Yunnan Province (No. ZX2019-03-01), China.
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Jingru LI, Haocheng MA, and Xinyu WU compiled the data, plotted the figures, and wrote the manuscript. Guihu SUN and Ping YANG performed the data collection. Yunzhu PENG, Qixian WANG, and Luqiao WANG were involved in the manuscript’s study design and initial review. All authors have read and approved the final manuscript, and therefore, have full access to all data in the study and are responsible for the integrity and security of the data.
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Jingru LI, Haocheng MA, Xinyu WU, Guihu SUN, Ping YANG, Yunzhu PENG, Qixian WANG, and Luqiao WANG declare that they have no conflict of interest.
This article does not contain any studies with human or animal subjects performed by any of the authors.
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Li, J., Ma, H., Wu, X. et al. Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction. J. Zhejiang Univ. Sci. B 24, 281–300 (2023). https://doi.org/10.1631/jzus.B2200459
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DOI: https://doi.org/10.1631/jzus.B2200459
Key words
- Exosome
- Non-exosomal non-coding RNA (ncRNA)
- Exosomal ncRNA
- Long non-coding RNA (lncRNA)
- MicroRNA (miRNA)
- Circular RNA (circRNA)
- Myocardial Infarction (MI)