摘要
为分析原发性开角型青光眼(primary open-angle glaucoma, POAG)黏小管成形术后早期短暂性高眼压的发生率及危险因素, 本研究纳入了本院顺利完成360°黏小管成形术的POAG患者。我们收集了以下数据: 术后各随访时间点眼压(intraocular pressure, IOP), 术后早期是否发生短暂性高眼压(定义: 术后1周至3月内IOP>21 mmHg但能回落至≤21 mmHg)及术后一周最低IOP(IOPmin-1w)。根据是否发生术后早期短暂性高眼压, 将其分为正常眼压组(normal IOP, NIOP)和短暂性高眼压组(high IOP, HIOP)。此外, 我们也对术后早期短暂性高眼压的相关危险因素进行了分析。最终来自57位患者的57只眼纳入分析。他们的平均视野缺损值(mean defect, MD)为(-15.57±10.13) dB, IOP由术前 (29.43±10.27) mmHg显著降低至术后1年的(14.73±3.60) mmHg(P<0.01)。其中, 20只眼发生HIOP(35.1%)。HIOP组的IOPmin-1w显著高于NIOP组(P<0.01), 并与较低的1年完全成功率相关。本研究结果提示POAG中黏小管成形术后HIOP组患者可能IOPmin-1w较高, 1年手术效果较差, 且IOPmin-1w≥12 mmHg可能是HIOP发生的独立危险因素。
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Acknowledgments
This work was supported by the National Natural Science Foundation of China (No. 82201177), the Health Commission of Zhejiang Province (No. 2023KY914), the Key R&D Program of Zhejiang (No. 2022C03112), the National Key R&D Program of China (No. 2020YFC2008200), the Zhejiang Provincial National Science Foundation of China (No. LQ18H120010), the Zhejiang Health Innovation Talents Program (No. 2016025), the Key Innovation and Guidance Program of the Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University (No. YNZD2201903), and the Wenzhou Municipal Technological Innovation Program of High-level Talents (No. 604090352/577).
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Lijuan XU: methodology, software, data acquisition and analysis, writing-original draft, revision, and funding acquisition; Xinyao ZHANG and Yang CAO: data acquisition and analysis; Yin ZHAO, Juan GU, Wenqing YE, and Jinxin LI: data acquisition; Xiaojie WANG: data analysis; Ruiyi REN: methodology, writing-reviewing and editing, revision, and supervision; Yuanbo LIANG: conceptualization, methodology, writing-reviewing and editing, funding acquisition, and supervision. All authors have read and approved the final manuscript, and therefore, have full access to all the data in the study and take responsibility for the integrity and security of the data.
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Lijuan XU, Xinyao ZHANG, Yang CAO, Yin ZHAO, Juan GU, Wenqing YE, Xiaojie WANG, Jinxin LI, Ruiyi REN, and Yuanbo LIANG declare that they have no conflict of interest.
This cross-sectional study adhered to the tenets of the Declaration of Helsinki and was approved by the Institutional Review Board of the Eye Hospital of Wenzhou Medical University (KYK[2014] No. 47). Written informed consent was exempted due to the nature of retrospective study.
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Xu, L., Zhang, X., Cao, Y. et al. Incidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma. J. Zhejiang Univ. Sci. B 24, 366–370 (2023). https://doi.org/10.1631/jzus.B2200485
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DOI: https://doi.org/10.1631/jzus.B2200485