Abstract
Mammalian bone is constantly metabolized from the embryonic stage, and the maintenance of bone health depends on the dynamic balance between bone resorption and bone formation, mediated by osteoclasts and osteoblasts. It is widely recognized that circadian clock genes can regulate bone metabolism. In recent years, the regulation of bone metabolism by non-coding RNAs has become a hotspot of research. MicroRNAs can participate in bone catabolism and anabolism by targeting key factors related to bone metabolism, including circadian clock genes. However, research in this field has been conducted only in recent years and the mechanisms involved are not yet well established. Recent studies have focused on how to target circadian clock genes to treat some diseases, such as autoimmune diseases, but few have focused on the co-regulation of circadian clock genes and microRNAs in bone metabolic diseases. Therefore, in this paper we review the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.
概要
哺乳动物的骨骼从胚胎阶段开始就不断地进行新陈代谢, 骨骼健康状态的维持依赖于破骨细胞和成骨细胞介导的骨吸收和骨形成之间的动态平衡。人们普遍认为, 生物钟基因可以调节骨代谢。近年来, 非编码RNAs对骨代谢的调控已成为研究热点。MicroRNAs可以通过靶向与骨代谢相关的关键因素参与骨的分解代谢和合成代谢, 其中包括生物钟基因。然而, 这一领域的研究在最近几年才开始进行, 所涉及的机制尚未明晰。最近的研究集中在如何靶向生物钟基因来治疗一些疾病(如自身免疫性疾病), 但少有人关注生物钟基因和microRNAs在骨代谢疾病中的共同调控问题。因此, 本文对生物钟基因和microRNAs共同调控骨代谢的研究进展进行了回顾, 旨在为预防和治疗骨代谢疾病(如骨质疏松症)提供新的思路。
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Acknowledgments
This work was supported by the National Natural Science Foundation of China (Nos. 81901430 and 81871835), the Guangdong Provincial Natural Science Foundation of China (No. 2022A1515010379), the Innovation Project from Department of Education of Guangdong Province (No. 2021KTSCX 055), the Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, and the Shanghai Key Laboratory for Human Athletic Ability Development and Support (Shanghai University of Sport) (No. 11DZ2261100), China.
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Tingting LI: conceptualization, data curation, formal analysis, resources, writing-original draft, writing-review and editing. Shihua ZHANG: data curation, formal analysis, writing-review and editing. Yuxuan YANG: data curation, writing-review and editing. Lingli ZHANG: writing-review and editing. Yu YUAN: funding acquisition, supervision, writing-original draft, writing-review and editing. Jun ZOU: funding acquisition, supervision, writing-review and editing, project administration. All authors have read and approved the final manuscript.
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Tingting LI, Shihua ZHANG, Yuxuan YANG, Lingli ZHANG, Yu YUAN, and Jun ZOU declare that they have no conflicts of interest.
This article does not contain any studies with human or animal subjects performed by any of the authors.
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Li, T., Zhang, S., Yang, Y. et al. Co-regulation of circadian clock genes and microRNAs in bone metabolism. J. Zhejiang Univ. Sci. B 23, 529–546 (2022). https://doi.org/10.1631/jzus.B2100958
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DOI: https://doi.org/10.1631/jzus.B2100958