Hypothalamo-Pituitary Dopaminergic System in Patients with Myotonic Dystrophy

HIROAKI SAKUMA; SADAO TAKASE; YASUJI MIZUNO; KAZUMINE TERAMURA; KUNIHIKO HANEW

doi:10.1620/tjem.156.291

HIROAKI SAKUMA, SADAO TAKASE, YASUJI MIZUNO, KAZUMINE TERAMURA, KUNIHIKO HANEW

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Keywords: myotonic dystrophy, hypothalamo-pituitary dopaminergic system, growth hormone, prolactin

JOURNAL FREE ACCESS

1988 Volume 156 Issue 3 Pages 291-298

DOI https://doi.org/10.1620/tjem.156.291

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Published: 1988 Received: August 11, 1988 Available on J-STAGE: August 31, 2006 Accepted: October 07, 1988 Advance online publication: - Revised: -
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Date of correction: August 31, 2006 Reason for correction: - Correction: ABSTRACT Details: Wrong : SAKUMA, H., TAKASE, S., MIZUNO, Y., TERAMURA, K. and HANEW, K. Hypothalamo-Pituitary Dopaminergic System in Patients with Myotonic Dystrophy. Tohoku J. exp. Med., 1988, 156 (3), 291-298 - We studied the function of hypothalamo-pituitary dopaminergic system in 15 myotonic dystrophy (MyD) patients whose growth hormone (GH) responses to insulin or arginine had been normal. We obtained the following findings: (1) basal levels of plasma GH and prolactin (PRL) were normal, although the latter levels were slightly lower than controls, (2) both GH and PRL responses to L-dopa or bromocriptine were significantly blunted compared with controls, (3) PRL response to sulpiLride was also significantly low compared with controls. These results indicate that hypothalamic dopaminergic neuron and its postsynaptic dopamine receptors relating to GH secretion might be impaired. It was also suggested that the dopamine receptors of pituitary PRL cells might be impaired and the PRL reserve of pituitary cells might be decreased in some case.
Right : We studied the function of hypothalamo-pituitary dopaminergic system in 15 myotonic dystrophy (MyD) patients whose growth hormone (GH) responses to insulin or arginine had been normal. We obtained the following findings : (1) basal levels of plasma GH and prolactin (PRL) were normal, although the latter levels were slightly lower than controls, (2) both GH and PRL responses to L-dopa or bromocriptine were significantly blunted compared with controls, (3) PRL response to sulpiride was also significantly low compared with controls. These results indicate that hypothalamic dopaminergic neuron and its postsynaptic dopamine receptors relating to GH secretion might be impaired. It was also suggested that the dopamine receptors of pituitary PRL cells might be impaired and the PRL reserve of pituitary cells might be decreased in some case.

Date of correction: August 31, 2006 Reason for correction: - Correction: AFFILIATION Details: Wrong :
1) Department of Neurology, Institute of Brain Diseases
2) the Second Department of Internal Medicine, Tohoku University School of Medicine

Right :
1) Department of Neurology, Institute of Brain Diseases Tohoku University School of Medicine
2) the Second Department of Internal Medicine, Tohoku University School of Medicine

Date of correction: August 31, 2006 Reason for correction: - Correction: KEYWORD Details: Wrong : myotonic dystrophy, hypothalamo -pituitary dopaminergic system, growth hormone; prolactin
Right : myotonic dystrophy, hypothalamo-pituitary dopaminergic system, growth hormone, prolactin

Date of correction: August 31, 2006 Reason for correction: - Correction: CITATION Details: Wrong : 1) Barreca, T., Muratorio, A., Murri, L., Rossi, B. & Rolandi, E. (1980) Evaluation of twenty-four-hour secretooy patterns of growth hormone and insulin in patients with myotonic dystrophy. J. clin. Endocr., 51, 1089-1092.
2) Calabro, M.A. & MacLeod, R.M. (1978) Binding of dopamine to bovine anterior pituitary gland membranes. Neuroendocrinology, 25, 32-46.
3) Camanni, F., Massara, F., Belforte, L. & Molinatti, G.M. (1975) Changes in plasma growth hormone levels in normal and acromegalic subjects following administration of 2-Bromo- α-ergocryptine. J. clin. Endocr., 40, 363-366.
4) Culebras, A., Podolsky, S. & Leopold, N.A. (1977) Absence of sleep-related growth hormone elevations in myotonic dystrophy. Neurology, 27, 165-167.
5) Hanew, K., Sato, S., Kasai, M., Murata, K., Shimizu, Y., Murakami, O. & Yoshinaga, K. (1983) Persistence of impaired PRL responses to sulpiride in patients with PRL secreting pituitary adenomas after successful hypophysectomy. Tohoku; J. exp. Med., 140, 225-233.
6) Henriksen, O.A., Sundsfjord, J.A. & Nyberg-Hansen, R. (1978) Evaluation of the endocrine functions in dystrophic myotonica. Acta neurol. scand., 58, 178-189.
7) Iwasaki, Y., Kato, Y., Chihara, K., Ohgo, S., Maeda, K. & Imura, H. (1976) Effect of sulpiride on plasma prolactin in rats. Neuroendocrinology, 21, 267-274.
8) Konagaya, Y., Konagaya, M. & Takayanagi, T. (1983) Tuberoinfundibular dopaminergic neuron function in Shy-Drager syndrome. Clin. Neurol. (Tokyo), 23, 861-866. (Japanese)
9) Kurachi, K., Shizume, K. & Toyokura, Y. (1983) Bromocriptine, Medical Tribune, Tokyo, p. 34. (Japanese)
10) Liuzzi, A., Verde, G. & Chiodini, P.G. (1978) Dopaminergic control of growth hormone secretion in acromegaly. Triangle (Biling.), 17, 41-47.
11) MacLeod, R.M. & Lehmeyer, J.E. (1974) Studies on the mechanism of the dopamine-mediated inhibition of prolactin secretion. Endocrinology, 94, 1077-1085.
12) Mahler, C. & Parizel, G. (1982) Hypothalamic-pituitary function in myotonic dystrophy. J. Neurol., 226, 233-242.
13) Martin, J.B. (1973) Neural regulation of growth hormone secretion. New Engl. J. Med., 288, 1384-1393.
14) Morgan, K.T. & Benedetti, M.S. (1977) Localization of a new neuroleptic in the pituitary gland of the rat. Experientia, 33, 1485-1486.
15) Nagasawa, H., Yanai, R. & Flückiger, E. (1973) Counteraction by 2-Br-α-ergocryptine of pituitary prolactin release promoted by dibutyryl-adenosine 3', 5'-monophosphate in rats. In: Human Prolactin, edited by J.L. Pasteels & C. Robyn, Excerpta Medica, Amsterdam, pp. 313-315.
16) Narita, S., Kudo, M., Kimura, K., Kitaoka, M., Baba, M., Matsunaga, M. & Toyota, T. (1977) Endocrinological study in myotonic dystrophy. Abstracts of the 11th World Congress of Neurology International Congress Series, No. 427. Excerpta Medica, Oxford-Amsterdam, p. 320.
17) Roses, A.D., Harper, P.S. & Bossen, E.H. (1979) Myotonic muscular dystrophy. In: Handbook of Clinical Neurology, Vol. 41, edited by P.J. Vinken & H.G. Bruyn, Elsevier North-Holland Pub. Comp., Amsterdam-New York-Oxford, p. 485.
18) Schams, D. (1972) Prolactin releasing effects of TRH in the bovine and their depression by a prolactin inhibitor. Horm. Metab. Res., 4, 405.
19) Takase, S. (1983) Endocrine abnormalities in myotonic dystrophy. Clin Neurol. (Tokyo), 23, 1086-1090. (Japanese)
20) Tashijian, A.H., Jr. & Hoyt, R., Jr. (1972) Transient controls of organ-specific functions in pituitary cells in culture. In: Molecular Genetics and Developmental Biology, edited by M. Sussman, Prentice-Hall, Engelwood Cliffs, New Jersey, pp. 353-387.
21) Yamamoto, M., Kito, S., Fujimori, N. & Kosaka, K. (1974) Endocrinological studies on myotonic dystrophy. Insulin and HGH (human growth hormone) responses in myotonic dystrophy. Clin. Neurol. (Tokyo), 14, 406-414. (Japanese)
22) Yoshinaga, K. & Sato, T. (1978) Clinical Endocrinology. Asakura Shoten, Tokyo, p. 36. (Japanese)

Right : 1) Barreca, T., Muratorio, A., Murri, L., Rossi, B. & Rolandi, E. (1980) Evaluation of twenty-four-hour secretory patterns of growth hormone and insulin in patients with myotonic dystrophy. J. clin. Endocr., 51, 1089-1092.
2) Calabro, M. A. & MacLeod, R. M. (1978) Binding of dopamine to bovine anterior pituitary gland membranes. Neuroendocrinology, 25, 32-46.
3) Camanni, F., Massara, F., Belforte, L. & Molinatti, G. M. (1975) Changes in plasma growth hormone levels in normal and acromegalic subjects following administration of 2-Bromo-α-ergocryptine. J. clin. Endocr., 40, 363-366.
4) Culebras, A., Podolsky, S. & Leopold, N. A. (1977) Absence of sleep-related growth hormone elevations in myotonic dystrophy. Neurology, 27, 165-167.
5) Hanew, K., Sato, S., Kasai, M., Murata, K., Shimizu, Y., Murakami, O. & Yoshinaga, K. (1983) Persistence of impaired PRL responses to sulpiride in patients with PRL secreting pituitary adenomas after successful hypophysectomy. Tohoku J. exp. Med., 140, 225-233.
6) Henriksen, O. A., Sundsfjord, J. A. & Nyberg-Hansen, R. (1978) Evaluation of the endocrine functions in dystrophia myotonica. Acta neurol. scand., 58, 178-189.
7) Iwasaki, Y., Kato, Y., Chihara, K., Ohgo, S., Maeda, K. & Imura, H. (1976) Effect of sulpiride on plasma prolactin in rats. Neuroendocrinology, 21, 267-274.
8) Konagaya, Y., Konagaya, M. & Takayanagi, T. (1983) Tuberoinfundibular dopaminergic neuron function in Shy-Drager syndrome. Clin. Neurol. (Tokyo), 23, 861-866. (Japanese)
9) Kurachi, K., Shizume, K. & Toyokura, Y. (1983) Bromocriptine, Medical Tribune, Tokyo, p. 34. (Japanese)
10) Liuzzi, A., Verde, G. & Chiodini, P. G. (1978) Dopaminergic control of growth hormone secretion in acromegaly. Triangle (Biling.), 17, 41-47.
11) MacLeod, R. M. & Lehmeyer, J. E. (1974) Studies on the mechanism of the dopaminemediated inhibition of prolactin secretion. Endocrinology, 94, 1077-1085.
12) Mahler, C. & Parizel, G. (1982) Hypothalamic-pituitary function in myotonic dystrophy. J. Neurol., 226, 233-242.
13) Martin, J. B. (1973) Neural regulation of growth hormone secretion. New Engl. J. Med., 288, 1384-1393.
14) Morgan, K. T. & Benedetti, M. S. (1977) Localization of a new neuroleptic in the pituitary gland of the rat. Experientia, 33, 1485-1486.
15) Nagasawa, H., Yanai, R. & Flückiger, E. (1973) Counteraction by 2-Br-α-ergocryptine of pituitary prolactin release promoted by dibutyryl-adenosine 3', 5'-monophosphate in rats. In: Human Prolactin, edited by J. L. Pasteels & C. Robyn, Excerpta Medica, Amsterdam, pp. 313-315.
16) Narita, S., Kudo, M., Kimura, K., Kitaoka, M., Baba, M., Matsunaga, M. & Toyota, T. (1977) Endocrinological study in myotonic dystrophy. Abstracts of the 11th World Congress of Neurology International Congress Series, No. 427. Excerpta Medica, Oxford-Amsterdam, p. 320.
17) Roses, A. D., Harper, P. S. & Bossen, E. H. (1979) Myotonic muscular dystrophy. In: Handbook of Clinical Neurology, Vol. 41, edited by P. J. Vinken & H. G. Bruyn, Elsevier North-Holland Pub. Comp., Amsterdam-New York-Oxford, p. 485.
18) Schams, D. (1972) Prolactin releasing effects of TRH in the bovine and their depression by a prolactin inhibitor. Horm. Metab. Res., 4, 405.
19) Takase, S. (1983) Endocrine abnormalities in myotonic dystrophy. Clin Neurol. (Tokyo), 23, 1086-1090. (Japanese)
20) Tashijian, A. H., Jr. & Hoyt, R., Jr. (1972) Transient controls of organ-specific functions in pituitary cells in culture. In: Molecular Genetics and Developmental Biology, edited by M. Sussman, Prentice-Hall, Engelwood Cliffs, New Jersey, pp. 353-387.
21) Yamamoto, M., Kito, S., Fujimori, N. & Kosaka, K. (1974) Endocrinological studies on myotonic dystrophy. Insulin and HGH (human growth hormone) responses in myotonic dystrophy. Clin. Neurol. (Tokyo), 14, 406-414. (Japanese)
22) Yoshinaga, K. & Sato, T. (1978) Clinical Endocrinology. Asakura Shoten, Tokyo, p. 36. (Japanese)

Date of correction: August 31, 2006 Reason for correction: - Correction: PDF FILE Details: -

Abstract

We studied the function of hypothalamo-pituitary dopaminergic system in 15 myotonic dystrophy (MyD) patients whose growth hormone (GH) responses to insulin or arginine had been normal. We obtained the following findings : (1) basal levels of plasma GH and prolactin (PRL) were normal, although the latter levels were slightly lower than controls, (2) both GH and PRL responses to L-dopa or bromocriptine were significantly blunted compared with controls, (3) PRL response to sulpiride was also significantly low compared with controls. These results indicate that hypothalamic dopaminergic neuron and its postsynaptic dopamine receptors relating to GH secretion might be impaired. It was also suggested that the dopamine receptors of pituitary PRL cells might be impaired and the PRL reserve of pituitary cells might be decreased in some case.

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