The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Combination Chemotherapy in Advanced Ovarian Cancer
AKIRA YAJIMA, HISASHI HIGASHIIWAI, AKIRA SATO, MASAAKI WATANABE, TOSHIHIKO MORI, MASAKUNI SUZUKI, TADAYOSHI HANYU, KEIGO SUZUKI, HYOTARO KUNII, TAKEJIRO MORITSUKA, NOBUHIRO IGARASHI, MORIO NAKANO, KAZUMARO NAGASAWA, SHIGEMI SATO
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Keywords: ovarian cancer, combination chemotherapy, antitumor response, survival rate of ovarian cancer
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1980 Volume 132 Issue 2 Pages 225-229

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Abstract

Among the 95 cases of ovarian cancer treated by us between May, 1975 and August, 1978, only 33 were suitable for complete resection. The remaining 62 cases underwent incomplete resection, followed by F. Q. C. combination chemotherapy (1-(2tetrahydrofuryl)-5-fluorouracil, carbazilquinone, cytosine arabinoside); 54.8% showed an antitumor response. The median survival time of the responders was 13.2 months, whereas it was 7.4 months for the non-responders. The survival rate after 24 months, however, was 13% and 4%, respectively. Side effects of the drugs, including leucopenia, thrombocytopenia, nausea and vomiting, were found in roughly one half of the cases.

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