The recently developed ultrasound elastography techniques are commonly designed to measure liver stiffness (LS), which has been established as surrogate marker of liver fibrosis[1]. When a tissue is compressed by mechanical force it generates shear-waves. The propagation speed of these shear-waves (SWS) is proportional to stiffness[2],and it can be used to calculate tissue elasticity. These ultrasound based techniques, such as point shear-wave elastography (pSWE) combine shear-wave imaging with conventional B-mode scans. These rely on acoustic radiation force impulse (ARFI) technology to generate shear-waves around a...

We prospectively enrolled 10 healthy volunteers as control group and 32 patients with known liver fibrosis into our study (Table 1). All pSWE was performed by two different observers on the same occasion. The observers were blinded from each other's measurements and from the patients' prior elastography results. Results of previoustransient elastography(TE) measurements were used as reference to assign METAVIR fibrosis stage to patients. Thresholds were obtained from published literature [4]. Basic clinical information (weight, height, age, gender, BMI), etiology of CLD, grade of fibrosis,...

The demographic and physiologic variables were compared with MANOVA test between the groups. There was no significant difference in average (µ) weight (µ=77kg, 95% CI = 70 - 85 vs.µ=69kg, 95% CI = 59 - 80 ) or height (µ=169cm, 95% CI = 163 - 174 vs.µ=173cm95% CI =163 - 183) or position of the measurement box from skin surface (µ=4.37cm, 95% CI = 4.14 - 4.59 vs.µ=4.05cm, 95% CI = 3.74 - 4.37) between patients and control subjects respectively. The median age andBMI were...

We found good inter-observer agreement using the S-Shearwave method. S-Shearwave also proved to be an accurate method for diagnosing liver fibrosis. Nearly identical cutoffs for the normal range were also calculated for both observers.

Correspondence to: Pal Novak Kaposi MD, PhD, Department of Radiology, Semmelweis University, Üllői út 78/a, Budapest, Hungary H-1083,[email protected]

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