The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis1,2
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- 1
Our work was supported by grants from the National Institutes of Health [U54: CA148967 (J.B. and G.A.-B.) and R01: CA87637 (J.B.)], Charles and Marjorie Holloway Foundation (J.B.), Sussman Family Fund (J.B.), Lerner Foundation (J.B.), AstraZeneca (J.B.), Breast Cancer Alliance (J.B.), Manhasset Women's Coalition Against Breast Cancer (J.B.), NYS Women's Bowling Association (J.B.), American Hellenic Educational Progressive Association 5th District (E.B. and D.L.), Department of Defense (Postdoctoral Award W81XWH-10-1-1013) and Fondazione Carisbo di Bologna (P.S.), Children's Cancer and Blood Foundation (D.L.), The Manning Foundation (D.L.), The Hartwell Foundation (D.L.), Pediatric Oncology Experimental Therapeutics Investigators Consortium (D.L.), Stavros S. Niarchos Foundation (D.L.), Champalimaud Foundation (D.L.), The Nancy C. and Daniel P. Paduano Foundation (D.L.), The Mary Kay Foundation (D.L.), The Malcolm Hewitt Wiener Foundation (D.L.), The George Best Costacos Foundation (D.L.), National Cancer Institute [R01CA 098234-01 and U54-CA143836 PSOC training grant (D.L.)], Susan G. Komen for the Cure (D.L.), and The Beth C. Tortolani Foundation (J.B. and D.L.). J.B. has consulted for Roche, Medimmune, and Bristol-Myers Squibb and has received research support from AstraZeneca. No potential conflicts of interest were disclosed by the other authors.
- 2
This article refers to supplementary materials, which are designated by Table W1 and Figures W1 to W4 and are available online at www.neoplasia.com.
- 3
These authors contributed equally to the manuscript.