Abstract

This study investigated the inhibitory effect and mechanism of curcumol on growth of human hepatocellular carcinoma (HCC) HepG2 xenografts in nude mice. Curcumol was isolated from from zedoary turmeric oil. The HepG2 xenograft model in nude mice was established. Forty modeled nude mice were divided into model, cisplatin, curcumol and cisplatin+curcumol groups. The latter three groups were treated with 2 mg/kg cisplatin, 100 mg/kg curcumol and 2 mg/kg cisplatin combined with 100 mg/kg curcumol, respectively, once every two days, for total seven times. After treatment, compared with cisplatin group, in cisplatin+curcumol group the tumor weight and tumor inhibition rate were obviously increased, the apoptosis rate of HepG2 cells was obviously increased, the expression levels of Caspase-3 and B-cell lymphoma-2 associated X proteins in xenograft tumor were significantly increased, and the expression level of B-cell lymphoma-2 protein was significantly decreased. In addition, the thymus index and spleen index of animal had no significant difference between cisplatin group and cisplatin+curcumol group. In conclusion, the additional use of curcumol can obviously increase the inhibitory effect of cisplatin on growth of HCC HepG2 xenografts in nude mice. The mechanism may be related to the enhanced promotion of apoptosis of tumor.

Keywords:
curcumol; hepatocellular carcinoma; HepG2; xenografts; apoptosis

Retracted Article

The editorial board of Food Science and Technology, announces the formal retraction of the following article:

Tian, Y., Pang, X., Wang, F. (2022). Isolation of curcumol from zedoary turmeric oil and its inhibitory effect on growth of human hepatocellular carcinoma xenografts in nude mice. Food Sci. Technol, Campinas, 42, e46621. https://doi.org/10.1590/fst.46621

This decision was made based on the fact that the article has a serious mistake in the contents. In preparing the work, due to author’s honest mistake, the data of thymus index were placed in the text. These data should be removed.

Prof. Dr. Adriano Gomes da Cruz, Editor-in-chief

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