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Viscoelastic Properties of Healthy Human Artery Measured in Saline Solution by AFM-Based Indentation Technique

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Abstract

Using an Atomic Force Microscope with an attachment for indentation, we have measured local, in vitro mechanical properties of healthy femoral artery tissue held in saline solution. The elastic modulus (34.3 kPa) and viscoelastic response (τɛ = 16.9 s and τσ = 29.3 s) of the unstretched, intimal vessel wall have been determined using Sneddon theory and a three element model (standard linear solid) for viscoelastic materials. The procedures necessary to employ the indenting attachment to detect elastic moduli in the kPa range in liquid are described.

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Authors and Affiliations

  1. Lawrence Livermore National Laboratory, Livermore, CA, 94550, USA

    E. Lilleodden, W. Siekhaus, J. Kinney & M. Balooch

  2. University of California, Berkeley, CA, 94720, USA

    A. Lundkvist & L. Pruitt

Authors
  1. A. Lundkvist
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  2. E. Lilleodden
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  3. W. Siekhaus
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  4. J. Kinney
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  5. L. Pruitt
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  6. M. Balooch
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Correspondence to M. Balooch.

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Lundkvist, A., Lilleodden, E., Siekhaus, W. et al. Viscoelastic Properties of Healthy Human Artery Measured in Saline Solution by AFM-Based Indentation Technique. MRS Online Proceedings Library 436, 353–358 (1996). https://doi.org/10.1557/PROC-436-353

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  • DOI: https://doi.org/10.1557/PROC-436-353

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