Abstract
A new cementitious calcium phosphate biomaterial, SuperBone®, was implanted in both a rabbit femoral canal model and a canine humeral plug model. New Zealand White rabbits were implanted with cement through a novel surgical approach where cement was introduced by injection. In the canine model, a uniform gap of 3 mm around a fiber metal porous implant was filled by the cement. Undecalcified light and backscattered electron histological evaluations indicate the cement is highly biocompatible and is replaced by new bone in concert with cell-mediated resorption. Unlike the acrylic bone cement positive controls, no evidence of fibrous tissue was found around the cement.
Similar content being viewed by others
References
Bauer, T.W.; Geesink, R.C.T.; Zimmerman, R.; McMahon, J.T. Hydroxyapatite-coated femoral stems. J. Bone Jt. Surg. 73-A:1439–1452; 1991.
Brown, W.E.; Chow, L.C. Dental restorative cement pastes. US patent 4,518,430. May 21, 1985.
Charnley, J. Cement-bone interface. Low frictional arthroplasty of the hip. Theory and practice. Berline: Springer-Verlag; 1979:25–40.
Constantz, B.R. In situ calcium phosphate minerals. US patent 4,880,610. November 12, 1989.
Dawson, K.; Faman, I.; Constantz, B.R.; Young, S.W. Solid-state phosphorus-31 nuclear magnetic resonance differentiation of bone mineral and synthetic apatite used to fill bone defects. Investigative Radiology. vol.26, no. 11. p.946–950. November 1991.
Gerhart, T.N.; Renshaw, A.A.; Miller, R.L.; Noecker, R.J.; Hayes, W.C. In-vivo histologic and biomechanical characterization of a biodegradable particulate composite bone cement. J. Biomed. Mater. Res. 23:1–16; 1989.
Goldring, S.R.; Schiller, A.L.; Roelke, M.; Rourke, C.M.; O’Neill, D.A.; Harris, W.H. The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis. J. Bone Jt. Surg. 65-A:575–584:1983.
Herman, J.H.; Sowder, W.G.; Anderson, D.; Appel, A.M.; Hopson, C.N. Polymethylmethacrylate-induced release of bone-resorbing factors. J. Bone Jt. Surg. 71-A:1530–1541; 1989.
Jasty, M.J.; Maloney, W.J.; Bragdon, C.R.; Haire, T.; Harris, W.H. Histomorphological studies of the long-term skeletal responses to well fixed cemented femoral components. J. Bone Jt. Surg. 72-A:1220–1229;1990.
Mirtchi, A.A.; Lemaitre, J.; Terao, N. Calcium phosphate cements: study of the B-tricalcium phosphate-monocalcium phosphate system. Biomaterials. 10:475–480; 1989.
Nishimura, N.; Yamamuro, T.; Taguchi, Y.; Ikenaga, M.; Nakamura, T.; Kokubo, T.; Yoshihara, S. A new bioactive bone cement: Its histological and mechanical characterization. J. of Applied Biomaterials. vol.2, no.4, 219–229; 1991.
Saha, S.; Pal, S. Mechanical properties of bone cement: a review. J. Biomed. Mater. Res. 18-435–462; 1984.
Sih, G.C.; Berman, A.T. Fracture toughness concept applied to methylmethacrylate. J. Biomed. Mater. Res. 14:311–324; 1980.
Young, S.W.; Dahlen, B.D.; Muller, H.H.; Rubin, D.L.; Constantz, B.R. Fracture and bone defect treatment using fibrous calcium phosphate and resorbable calcium phosphate cement (abstr.) In: Book of Abstracts, Society for Magnetic Resonance Imaging 8th Annual Meeting, Washington, DC, 1990;24.
Young, S.W.; Dahlen, B.D.; Muller, H.H.; Gunasekaran, S.; Rubin, D.L.; Constantz, B.R. MR and radiographic imaging of resorbable injectable synthetic bone in vivo. in preparation.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Constantz, B.R., Young, S.W., Kienapfel, H. et al. Calcium Phosphate Cement in a Rabbit Femoral Canal Model and a Canine Humeral Plug Model: A Pilot Investigation. MRS Online Proceedings Library 252, 79–85 (1991). https://doi.org/10.1557/PROC-252-79
Published:
Issue Date:
DOI: https://doi.org/10.1557/PROC-252-79