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3D models of the bone marrow in health and disease: yesterday, today, and tomorrow

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Abstract

The complex interaction between hematopoietic stem cells (HSCs) and their microenvironment in the human bone marrow ensures a life-long blood production by balancing stem cell maintenance and differentiation. This so-called HSC niche can be disturbed by malignant diseases. Investigating their consequences on hematopoiesis requires a deep understanding of how the niches function in health and disease. To facilitate this, biomimetic models of the bone marrow are needed to analyze HSC maintenance and hematopoiesis under steady state and diseased conditions. Here, 3D bone marrow models, their fabrication methods (including 3D bioprinting), and implementations recapturing bone marrow functions in health and diseases are presented.

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Acknowledgments

We thank the publishers Elsevier, Taylor and Francis Ltd., BioMed Central, Springer Nature, John Wiley and Sons for the permission to reprint published data shown in Figs. 3(a)[47], 3 (b)[49], 3(c)[50], Figs. 4(a), 4(b)[124], 4(c)[121], 4(d), 4(e)[125]. This project has received funding from the European Research Council (ERC) under the European Union’ s Horizon 2020 research and innovation programme (grant agreement No 757490). C.L.-T. and A.R. acknowledge funding from the BMBFNanoMatFutur programme (FKZ 13N12968)andthepro-gramme BioInterfaces in Technology and Medicine (BIFTM) by the Helmholtz Association.

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  1. Karlsruhe Institute of Technology (KIT), Institute of Functional Interfaces, 76344, Eggenstein-Leopoldshafen, Germany

    Annamarija Raic, Toufik Naolou, Anna Mohra, Chandralekha Chatterjee & Cornelia Lee-Thedieck

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Raic, A., Naolou, T., Mohra, A. et al. 3D models of the bone marrow in health and disease: yesterday, today, and tomorrow. MRS Communications 9, 37–52 (2019). https://doi.org/10.1557/mrc.2018.203

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