Abstract
A methodology for the ex ante evaluation of different processing options is proposed. Current processes for glucose oxidation and possible improvements using microreactor technology are investigated. As twofold prime research objectives, the oxidation with noble metal catalyst versus enzymatic oxidation and the oxidation under conventional process conditions versus under Novel Process Windows are explored. Operation and design of an active and stable catalyst, reactor performance, and work-up are included. This ex ante analysis gives information of the critical aspects of a process prior to technology development and facilitates the development of new process routes; especially valuable if step and paradigm changing routes are undertaken, with even no vague idea on their performance potential and with high technological risk. The methodology used for gluconic acid production will be transferred to other chemicals which have the potential in using microreactor technology and Novel Process Windows.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Röper, H.; Koch, H. Starch/Stärke 1988, 40, 453.
Vleeming, J. H. Deactivation of Carbon Supported Platinum Catalyst During Carbohydrate Oxidation. Ph.D. Thesis, Eindhoven University of technology, Eindhoven, 1997.
Biella, S.; et al. J. Catal. 2002, 206, 242–247.
Commoti, M.; et al. J. Catal. 2006, 244, 122–125.
Commoti, M.; et al. J. Mol. Catal. A Chem. 2006, 251, 89–92.
Znad, H.; et al. Process Biochem. 2004, 39, 1341–1345.
Ramachandran, S.; et al. Food Technol. Biotechnol. 2006, 44(2), 185–195.
Illg, T.; Löb, P.; Hessel, V. Bioorg. Med. Chem. 2010, 18(11), 3707–3719.
Hessel, V.; Hardt, S.; Löwe, H. Chemical Micro Process Engineering–Fundamentals, Modelling and Reactions; Wiley-VCH: Weinheim, 2004.
Hessel, V.; Knobloch, C.; Löwe, H. Recent Patents Chem. Eng. 2008, 1, 1–16.
Roberge, D.; Ducry, L.; Bieler, N.; Cretton, P.; Zimmermann, B. Chem. Eng. Technol. 2005, 28(3), 318–323.
Ehrfeld, W.; Hessel, V.; Lowe, H. Microreactors: New Technology for Modern Chemistry; Wiley-VCH: Weinheim, 2000.
Jensen, K. F. Chem. Eng. Sci. 2001, 56, 293–303.
Pennemann, H.; et al. Chem. Eng. Sci. 2004, 59, 4789–4794.
POLYCAT. EU large-scale project, modern polymer-based catalysts and microflow conditions as key elements of innovations in fine chemical synthesis; 2010.
Wang, S. Anal. Biochem. 2010, 405, 230–235.
Gangwal, V. Platinum Catalyzed Alcohol Oxidation: Kinetics, Reaction Engineering and Process Design. Ph.D. Thesis, Eindhoven University of technology, Eindhoven, 2005.
Besson, M.; Gallezot, P. Catal. Today 2000, 57, 127–141.
Swarts, J. Chem. Eng. J. 2010, 162, 301–306.
Miyazaki, M.; et al. Biotechnol. Genet. Eng. Rev. 2008, 25, 405–428.
European roadmap for process intensification, http://www.senternovem.nl/mmfiles/Report%2520%2527European%2520Roadmap%2520for%2520Process%2520Intensification%2527_tcm24-258503_tcm24-271299.pdf, last accessed: Apr 2011.
Huebschmann, S.; Kralisch, D.; Hessel, V.; Krtschil, U.; Kompter, C. Chem. Eng. Technol. 2009, 32(11), 1757–1765.
Hessel, V. Chem. Eng. Technol. 2009, 32(11), 1655–1681.
Hessel, V.; Kralisch, D.; Krtschil, U. Energy Environ. Sci. 2008, 1(4), 467–478.
Kralisch, D.; Kreisel, G. Chem. Eng. Sci. 2007, 62(4), 1094.
Kralisch, D. Application of LCA in Process Development. In Green Chemistry Metrics: Measuring and Monitoring Sustainable Processes; Lapkin, A., Constable, D. J. C., Eds.; John Wiley, Chichester, UK, 2009.
Krtschil, U.; Hessel, V.; Kralisch, D.; Kreisel, G.; Küpper, M.; Schenk, R. Chimia 2006, 60(9), 611–617.
Hessel, V.; Cortese, B.; de Croon, M. H. J. M. Chem. Eng. Sci. DOI:10.1016/j.ces.2010.08.018.
Malat, T.; Baiker, A. Catal. Today 1995, 24, 143–150.
Dijkgraaf, P. J. M. Oxidation of Glucose to Glucaric Acid by Pt/C Catalyst. Ph.D. Thesis, Eindhoven University of Technology, Eindhoven, 1989.
Gogová, Z.; Hanika, J. Chem. Eng. J. 2009, 150, 223–230.
Matveeva, V.; et al. Top Catal. 2009, 52, 387–393.
Önal, Y.; Schimpf, S.; Claus, P. J. Catal. 2004, 223, 122–133.
Odebunmi, E. O.; Owalude, S. O. J. Appl. Sci. Environ. Manag. 2007, 11(4), 95–100.
Beltrame, P. J. Catal. 2004, 228, 282–287.
Klein, J.; et al. Biochem. Eng. J. 2002, 10, 197–205.
Doneva, T.; Vassilief, C.; Donev, R. Biotechnol. Lett. 1999, 21, 1107–1111.
Blandino, A.; Macias, M.; Cantero, D. Process Biochem. 2001, 36, 601–606.
Bankar, S. B.; et al. Biotechnol. Adv. 2009, 27, 489–501.
Godjevargova, T.; Dayal, R.; Turmanova, S. Macromol. Biosci. 2004, 4, 950–956.
Hestekin, J. A.; et al. J. Appl. Electrochem. 2002, 32, 1049–1052.
Giorno, L.; Drioli, E. TIBTECH 2000, 18, 339–349.
Bao, J.; et al. Biochem. Eng. J. 2004, 22, 33–41.
Miron, J.; et al. Enzym. Microb. Technol. 2004, 34, 513–522.
Astruc, D. Nanoparticles and Catalysis; Wiley-VCH: Weinheim, 2008; p 412.
Dworkin, M.; et al. (2006) The Prokaryotes: A Handbook of the Biology of Bacteria: Symbiotic Associations, Biotechnology, Applied Microbiology; Springer Science and Business Media, 2006; Vol. 1.
Sulman, E.; et al. J. Mol. Catal. A Chem. 2007, 278, 112–119.
Rahman, M.; Heikkilä, A. M.; Hurme, M. J. Loss Prev. Proc. Ind. 2005, 18, 327.
IMM Falling film microreactor, technical data, http://www.immmainz.de/fileadmin/IMM-upload/Flyer-Katalog_etc/Catalogue09_FFMR.pdf, last accessed: Mar 2011.
Zanfir, M. Ind. Eng. Chem. Res. 2005, 44, 1742–1751.
Ehrich, H.; Linke, D.; Morgenschweis, K.; Baerns, M.; Jaehnisch, K. Chimia 2002, 56, 647–653.
Yeong, K. K.; et al. Catal. Today 2003, 81, 641–651.
Jaehnisch, K.; Baerns, M.; Hessel, V.; Ehrfeld, W.; Haverkamp, V.; Loewe, H.; Wille, C.; Guber, A. J. Fluor. Chem. 2000, 105, 117–128.
Vankayala, B. K.; et al. Int. J. Chem. React. Eng. 2007, 5, Article A91.
Commenge, J. M.; et al. Chem. Eng. Sci. 2006, 61, 597–604.
Commenge, J. M.; et al. Chem. Eng. Sci. 2011, 66, 1212–1218.
van Male, P.; et al. Int. J. Heat Mass Tran. 2004, 47, 87–99.
Ullmann’s Encyclopedia of Industrial Chemistry; Wiley-VCH: Weinheim, 2007; Electronic Release.
Tonkovich, A. Trans IChemE A Chem. Eng. Res. Des. 2005, 83(A6): 634–639.
Losey, M. W.; Schmidt, M. A.; Jensen, K. F. Ind. Eng. Chem. Res. 2001, 40, 2555–2562.
Al Dahhan, Larachi, Dudukovic, Laurent. Ind. Eng. Chem. Res. 1997, 36(8), 3292–3314.
White, R.; et al. Chem. Soc. Rev. 2009, 38, 481–494.
Sheldon, R. Adv. Synth. Catal. 2007, 349, 1289–1307.
Krenkova, J.; Foret, F. Electrophoresis 2004, 25, 3550–3563.
Matosevic, S. Biotechnol. Prog. 2010, 26(1), 118–126.
Urban, P. L.; et al. Biotechnol. Adv. 2006, 24, 42–57.
Schilke, K. Biotechnol. Prog. 2010, 26(6), 1597–1605.
Thomsen, M. Biotechnol. J. 2009, 4, 98–107.
Ji, X.; et al. Talanta 2010, 82, 1170–1174.
Matsuura, S.; et al. Chem. Eng. J. 2010.
Mugo, M.; et al. J. Mol. Catal. B Enzym. 2010, 67, 202–207.
Miyazaki, M.; et al. Chem. Eng. J. 2004, 101, 277–284.
Mohr, X.; et al. Lab Chip 2010, 10, 1929–1936.
Baiker, A. Chem. Rev. 1999, 99, 453–473.
Kayrak-Talay, D.; Akman, U.; Hortac, O. J. Supercrit. Fluids 2007, 42, 273–281.
CheManager, www.chemanager-online.com, last accessed: Jun 2011.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dencic, I., Meuldijk, J., de Croon, M. et al. From a Review of Noble Metal versus Enzyme Catalysts for Glucose Oxidation Under Conventional Conditions Towards a Process Design Analysis for Continuous-flow Operation. J Flow Chem 1, 13–23 (2011). https://doi.org/10.1556/jfchem.2011.00005
Published:
Issue Date:
DOI: https://doi.org/10.1556/jfchem.2011.00005