Clinical Studies on the Cardiac Performance by Means of Transseptal Left Heart Catheterization II. Left Ventricular Function in High Output Heart Diseases, Especially in Hyperthyroidism

Hideo UEDA; Yasuro SUGISHITA; Atsuo NAKANISHI; Iwao ITO; Hisakazu YASUDA; Masaya SUGIURA; Yutaka TAKABATAKE; Keiji UEDA; Tadashi KOIDE; Katsuhiko OZEKI

doi:10.1536/ihj.6.396

Clinical Studies on the Cardiac Performance by Means of Transseptal Left Heart Catheterization

II. Left Ventricular Function in High Output Heart Diseases, Especially in Hyperthyroidism

Hideo UEDA, Yasuro SUGISHITA, Atsuo NAKANISHI, Iwao ITO, Hisakazu YASUDA, Masaya SUGIURA, Yutaka TAKABATAKE, Keiji UEDA, Tadashi KOIDE, Katsuhiko OZEKI

Author information

Hideo UEDA
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Yasuro SUGISHITA
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Atsuo NAKANISHI
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Iwao ITO
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Hisakazu YASUDA
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Masaya SUGIURA
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Yutaka TAKABATAKE
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Keiji UEDA
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Tadashi KOIDE
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Katsuhiko OZEKI
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

JOURNAL FREE ACCESS

1965 Volume 6 Issue 5 Pages 396-406

DOI https://doi.org/10.1536/ihj.6.396

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Abstract

In the resting state of 6 cases of hyperthyroidism and 2 cases of anemia, and before and after infusion of 6% PVP 5 ml./Kg. body weight in 3 normal and 3 hypertensive cases, the left ventricular performance was studied by the transseptal left heart catheterization using radioisotope dilution method and compared with those of normal and low output failure. Thus following results were obtained;
In hyperthyroidism, with the increase of heart rate, stroke volume was increased, which may be caused by the acceleration of left ventricular function shown by the change of CSR and MSER, and by the increase of blood inflow shown by increase of LVEDV.
The high output state in induced hypervolemia is due to the increase of blood inflow, but the left ventricular function is rather depressed.
In conclusion, thyrotoxic heart is not only accelerated by thyroid hor-mone but also overloaded by increased venous return.

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