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Effectiveness and Limitation of Gamma Knife Radiosurgery for Relapsed Central Nervous System Lymphoma: A Retrospective Analysis in One Institution

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Abstract

We describe 6 patients with relapsed central nervous system lymphoma (CNSL) treated with Gamma Knife radiosurgery (GKR). The histologic diagnosis in all 6 patients was diffuse large B-cell lymphoma without human immunodeficiency virus infection. Two patients had intracranial relapse of primary CNSL, and the remaining 4 had CNS relapse of systemic lymphoma. All patients were treated with GKR without severe adverse effects, and all but 1 patient received subsequent chemotherapy shortly after GKR. Four patients showed a complete response, and the remaining 2 patients had a partial response or stable disease. Although the neurologic symptoms disappeared or improved markedly in all patients, all of the diseases recurred or progressed 3 to 13 months after the first GKR. A second GKR was eventually performed in 4 patients. The median overall survival and progression-free survival times after the first GKR were 17 and 11 months, respectively. In our experience, GKR seems to be a useful procedure for the treatment of relapsed CNSL, because it facilitates excellent local control in a short-term treatment period without severe complications, although the efficacy period is not long enough.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan

    Yosuke Matsumoto, Shigeo Horiike, Yoshiko Fujimoto, Daisuke Shimizu, Kenichi Nomura, Yutaka Kobayashi, Chihiro Shimazaki & Masafumi Taniwaki

  2. Department of Molecular Laboratory Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan

    Daisuke Shimizu & Masafumi Taniwaki

  3. Research Institute for Neurological Diseases and Geriatrics Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan

    Yuriko Kudo-Nakata

  4. Department of Neurosurgery, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan

    Satoshi Kimura

  5. Gamma Knife Center, Rakusai Shimizu Hospital, Kyoto, Japan

    Manabu Sato

  6. Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan

    Hiroto Kaneko

Authors
  1. Yosuke Matsumoto
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  2. Shigeo Horiike
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  3. Yoshiko Fujimoto
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  4. Daisuke Shimizu
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  5. Yuriko Kudo-Nakata
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  6. Satoshi Kimura
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  7. Manabu Sato
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  8. Kenichi Nomura
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  9. Hiroto Kaneko
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  11. Chihiro Shimazaki
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  12. Masafumi Taniwaki
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Correspondence to Yosuke Matsumoto.

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Matsumoto, Y., Horiike, S., Fujimoto, Y. et al. Effectiveness and Limitation of Gamma Knife Radiosurgery for Relapsed Central Nervous System Lymphoma: A Retrospective Analysis in One Institution. Int J Hematol 85, 333–337 (2007). https://doi.org/10.1532/IJH97.06205

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  • DOI: https://doi.org/10.1532/IJH97.06205

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