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Expression of Human Tumor-Associated Antigen RCAS1 in Adult T-Cell Leukemia/Lymphoma

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Abstract

In human cancer, RCAS1 (the receptor-binding cancer antigen expressed on SiSo cells) on the surface of various kinds of tumor cells reportedly induces the apoptosis of T-cells and natural killer cells, resulting in evasion of the immune system. In the present study, an immunohistochemical analysis of RCAS1 expression was performed with lymph node specimens obtained from patients with adult T-cell leukemia/lymphoma (ATLL). Positive staining was seen in 15 (75%) of 20 cases and in all cases of patients with short survival times. In the cases of B-cell lymphomas, positive staining was seen in only 1 (13%) of 8 cases. These findings indicate that expression of RCAS1 may be associated with the evasion from immune surveillance of cells infected with human T-lymphotropic virus type I, resulting in the development of overt leukemia/lymphoma. Determination of RCAS1 expression may be useful for predicting the prognosis of patients with ATLL.

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Authors and Affiliations

  1. Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi-ku, 812-8582, Fukuoka, Japan

    Koichiro Muta, Yasunobu Abe, Ilseung Choi, Takamitsu Matsushima & Hajime Nawataa

  2. Department of Pathology, School of Medicine, Fukuoka University, Maidashi 3-1-1, Higashi-ku, 812-8582, Fukuoka, Japan

    Koichi Ohshima & Masahiro Kikuchi

  3. Department of Hematology, National Hospital Kyushu Cancer Center, Maidashi 3-1-1, Higashi-ku, 812-8582, Fukuoka, Japan

    Naokuni Uike

  4. Department of Molecular Immunology and Clinical Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi 3-1-1, Higashi-ku, 812-8582, Fukuoka, Japan

    Junji Nishimura, Manabu Nakashima & Takeshi Watanabe

Authors
  1. Koichiro Muta
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  2. Koichi Ohshima
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  3. Yasunobu Abe
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  4. Naokuni Uike
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  5. Ilseung Choi
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  6. Takamitsu Matsushima
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  7. Junji Nishimura
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  8. Masahiro Kikuchi
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  9. Manabu Nakashima
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  10. Takeshi Watanabe
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  11. Hajime Nawataa
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Correspondence to Koichiro Muta.

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Muta, K., Ohshima, K., Abe, Y. et al. Expression of Human Tumor-Associated Antigen RCAS1 in Adult T-Cell Leukemia/Lymphoma. Int J Hematol 79, 340–344 (2004). https://doi.org/10.1532/IJH97.03109

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  • DOI: https://doi.org/10.1532/IJH97.03109

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