Abstract
Hematopoietic stem cell (HSC) plasticity and its clinical application have been studied profoundly in the past few years. Recent investigations indicate that HSC and other bone marrow stem cells can develop into other tissues. Because of the high morbidity and mortality of myocardial infarction and other heart disorders, myocardial regeneration is a good example of the clinical application of HSC plasticity in regenerative medicine. Preclinical studies in animals suggest that the use of this kind of treatment can reconstruct heart blood vessels, muscle, and function. Some clinical study results have been reported in the past 2 years. In 2003, reports of myocardial regeneration treatment increased significantly. Other studies include observations on the cell surface markers of transplanted cells and treatment efficacy. Some investigations, such as HSC testing, have focused on clinical applications using HSC plasticity and bone marrow transplantation to treat different types of disorders. In this review, we focus on the clinical application of bone marrow cells for myocardial regeneration.
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References
Herzong EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells.Blood. 2003;102:3483–3493.
Triology stem cell page. Lightworker Web site. Available at: http:// www.lightworker.com/triology/library_stem_cell.shtml. Accessed February 2,2004.
Graf T. Differentiation plasticity of hematopoietic cells.Blood. 2002;99:3089–3101.
Mertelsmann R. Plasticity of bone marrow-derived stem cells.J Hematother Stem Cell Res. 2000;9:957–960.
Krause DS. Plasticity of marrow-derived stem cells.Gene Ther. 2002;9:754–758.
Goodell MA, Jackson KA, Majka SM, et al. Stem cell plasticity in muscle and bone marrow.Ann N Y Acad Sci. 2001;938:208–218; discussion 218-220.
Hirschi KK, Goodell MA. Hematopoietic, vascular and cardiac fates of bone marrowderived stem cells.Gene Ther. 2002;9:648–652.
Tse WT, Egalka MC. Stem cell plasticity and blood and marrow transplantation: a clinical strategy.J Cell Biochem Suppl. 2002;38:96–103.
Jensen GS, Drapeau C. The use of in situ bone marrow stem cells for the treatment of various degenerative diseases.Med Hypotheses. 2002;59:422–428.
Tisdale JF, Dunbar CE. Plasticity and hematopoiesis: Circe’s transforming potion?Curr Opin Hematol. 2002;9:268–273.
Horwitz EM. Stem cell plasticity: a new image of the bone marrow stem cell.Curr Opin Pediatr. 2003;15:32–37.
Keller R. Stem cells on the way to restorative medicine.Immunol Lett. 2002;83:1–12.
Quesenberry PJ, Colvin GA, Lambert JF, et al. The new stem cell biology.Trans Am Clin Climatol Assoc. 2002;113:182–206; discussion 206-207.
Sanchez-Ramos JR. Neural cells derived from adult bone marrow and umbilical cord blood.J Neurosci Res. 2002;69:880–893.
Frisen J. Stem cell plasticity?Neuron. 2002;35:415–418.
Quesenberry P, Habibian H, Dooner M, et al. Physical and physiological plasticity of hematopoietic stem cells.Blood Cells Mol Dis. 2001;27:934–937.
Triffitt JT. Stem cells and the philosopher’s stone.J Cell Biochem Suppl. 2002;38:13–19.
Poulsom R, Alison MR, Forbes SJ, Wright NA. Adult stem cell plasticity.J Pathol. 2002;197:441–456.
Theise ND. New principles of cell plasticity.C R Biol. 2002;325: 1039–1043.
Devine SM, Cobbs C, Jennings M, Bartholomew A, Hoffman R. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into non-human primates.Blood. 2003; 101:2999–3001.
Koc ON, Day J, Nieder M, Gerson SL, Lazarus HM, Krivit W. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH).Bone Marrow Transplant. 2002;30:215–222.
Gojo S, Kyo S. Regenerative potential of mesodermal stem cells for the heart [in Japanese].Nippon Geka Gakkai Zasshi. 2002;103: 616–622.
Pelled G, Aslan H, Gazit Z, Gazit D. Mesenchymal stem cells for bone gene therapy and tissue engineering.Curr Pharm Des. 2002; 8:1917–1928.
Devine SM, Peter S, Martin BJ, Barry F, McIntosh KR. Mesenchymal stem cells: stealth and suppression.Cancer J. 2001; 7(suppl 2):S76-S82.
Fukuda K. Generation of cardiomyocytes from mesenchymal stem cells [in Japanese].Tanpakushitsu Kakusan Koso. 2000;45(suppl):2078–2084.
Raeburn CD, Zimmerman MA, Arya J, Banerjee A, Harken AH. Stem cells and myocardial repair.J Am Coll Surg. 2002;195:686–693.
Kessler PD, Byrne BJ. Myoblast cell grafting into heart muscle: cellular biology and potential applications.Annu Rev Physiol. 1999; 61:219–242.
Hagege AA, Menasche P. Cellular cardiomyoplasty: a new hope in heart failure?Heart. 2000;84:465–466.
El Oakley RM, Ooi OC, Bongso A, Yacoub MH. Myocyte transplantation for myocardial repair: a few good cells can mend a broken heart.Ann Thorac Surg. 2001;71:1724–1733.
Menasche P. Cell therapy of heart failure.C R Biol. 2002;325:731–738.
Menasche P. Cell transplantation for the treatment of heart failure.Semin Thorac Cardiovasc Surg. 2002;14:157–166.
Menasche P. Myoblast transplantation for the treatment of heart failure.Minerva Cardioangiol. 2002;50:565–568.
Hughes S. Cardiac stem cells.J Pathol. 2002;197:468–478.
Orlic D, Kajstura J, Chimenti S, Bodine DM, Leri A, Anversa P. Bone marrow stem cells regenerate infarcted myocardium.Pediatr Transplant. 2003;7(suppl):86–88.
Al Attar N, Razak AB, Scorsin M. Cellular transplantation: new horizons in the surgical management of heart failure.J R Coll Surg Edinb. 2002;47:749–752.
Scorsin M, Souza LC. Cellular transplantation for the treatment of heart failure: state of the art.Arq Bras Cardiol. 2001;77:103–106.
Gulbins H, Meiser BM, Reichenspurner H, Reichart B. Cell transplantation: a potential therapy for cardiac repair in the future?Heart Surg Forum 2002;5:E28-E34.
Li Q, Gao W, Chen G. Stem cell transplantation for repairment of injured myocardium [in Chinese].Zhonghua Yi Xue Za Zhi. 2001; 81:1401–1403.
Boheler KR, Czyz J, Tweedie D, Yang HT, Anisimov SV, Wobus AM. Differentiation of pluripotent embryonic stem cells into cardiomyocytes.Circ Res. 2002;91:189–201.
Makino S, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro.J Clin Invest. 1999;103: 697–705.
Yau TM, Tomita S, Weisel RD, et al. Beneficial effect of autologous cell transplantation on infarcted heart function: comparison between bone marrow stromal cells and heart cells.Ann Thorac Surg. 2003;75:169–176; discussion 176–177.
Orlic D. Stem cell repair in ischemic heart disease: an experimental model.Int J Hematol. 2002;76(suppl 1):144–145.
Orlic D, Kajstura J, Chimenti S, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival.Proc Natl Acad Sci U S A. 2001;98:10344–10349.
Fuchs S, Baffour R, Zhou YF, et al. Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia.J Am Coll Cardiol. 2001;37:1726–1732.
Hamano K, Li TS, Kobayashi T, et al. Therapeutic angiogenesis induced by local autologous bone marrow cell implantation.Ann Thorac Surg. 2002;73:1210–1215.
Orlic D, Kajstura J, Chimenti S, Bodine DM, Leri A, Anversa P. Transplanted adult bone marrow cells repair myocardial infarcts in mice.Ann N Y Acad Sci. 2001;938:221–229; discussion 229–230.
Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium.Nature. 2001;410:701–705.
Jackson KA, Majka SM, Wang H, et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells.J Clin Invest. 2001;107:1395–1402.
Orlic D. Adult BM stem cells regenerate mouse myocardium.Cytotherapy. 2002;4:521–525.
Dengler TJ, Katus HA. Stem cell therapy for the infarcted heart (“cellular cardiomyoplasty”).Herz. 2002;27:598–610.
Muller-Ehmsen J, Kedes LH, Schwinger RH, Kloner RA. Cellular cardiomyoplasty: a novel approach to treat heart disease.Congest Heart Fail. 2002;8:220–227.
Penn MS, Francis GS, Ellis SG, Young JB, McCarthy PM, Topol EJ. Autologous cell transplantation for the treatment of damaged myocardium.Prog Cardiovasc Dis. 2002;45:21–32.
Kocher AA, Schuster MD, Szabolcs MJ, et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function.Nat Med. 2001;7:430–436.
Malouf NN, Coleman WB, Grisham JW, et al. Adult-derived stem cells from the liver become myocytes in the heart in vivo.Am J Pathol. 2001;158:1929–1935.
Tomita S, Li RK, Weisel RD, et al. Autologous transplantation of bone marrow cells improves damaged heart function.Circulation. 1999;100(suppl):II-247–256.
Condorelli G, Borello U, De Angelis L, et al. Cardiomyocytes induce endothelial cells to trasns-differentiate into cardiac muscle: implications for myocardium regeneration.Proc Natl Acad Sci U S A. 2001;98:10733–10738.
Min JY, Yang U, Converso KL, et al. Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats.J Appl Physiol. 2002;92:288–296.
Quaini F, Urbanek K, Beltrami AP, et al. Chimerism of the transplanted heart.N Engl J Med. 2002;346:5–15.
Orlic D, Arai AE, Sheikh FH, et al. Cytokine myobilized CD34+ cells do not benefit rhesus monkeys following induced myocardial infarction [abstract]. Paper presented at: American Society of Hematology 44th Annual Meeting; December 6-10,2002; Philadelphia, Pa.
Hamano K, Li TS, Kobayashi T, et al. Therapeutic angiogenesis induced by local autologous bone marrow cell implantation.Ann Thorac Surg. 2002;73:1210–1215.
Strauer BE, Brehm M, Zeus T, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans.Circulation. 2002;106:1913–1918.
Strauer BE, Brehm M, Zeus T, et al. Intracoronary, human autologous stem cell transplantation for myocardial regeneration following myocardial infarction [in German].Dtsch Med Wochenschr. 2001;126:932–938.
Coalition of Americans for Research Ethics. DoNoHarm Web site. Available at: http://www.stemcellresearch.org/stemcellreport/ scr-2001fall.htm. Accessed February 2,2004.
Stamm C, Westphal B, Kleine HD, et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration.Lancet. 2003;361:45–46.
Tse HF, Kwong YL, Chan JK, Lo G, Ho CL, Lau CP. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation.Lancet. 2003;361:47–49.
Laham RJ, Oettgen P. Bone marrow transplantation for the heart: fact or fiction?Lancet. 2003;361:11–12.
Self-mended heart: boy’s own blood used for first-of-its-kind stem cell transplant. ABC News Web site. Available at: http://abcnews. go.com/sections/GMA/Living/GMA030306Stem_cell_heart.html. Accessed February 2,2004.
UPI Web site. Available at: http://www.upi.com/view.cfm?StoryID= 20030305-053917-3903r. Accessed February 2,2004.
Wang FS, Dorfener M, Hamaguchi Y, Hirai K. Preliminary investigation of CD34 negative hematopoietic stem cells on the automated hematology analyzer [abstract].Blood. 2002;100:147b.
Rosenthal N, Tsao L. Helping the heart to heal with stem cells.Nat Med. 2001;7:412–413.
Mezey E, Key S, Vogelsang G, Szalayova I, Lange GD, Crain B. Transplanted bone marrow generates new neurons in human brains.Proc NatlAcad Sci U S A. 2003;100:1364–1369.
Hirschi KK, Goodell MA. Hematopoietic, vascular and cardiac fates of bone marrow-derived stem cells.Gene Ther. 2002;9:648–652.
Vogel G. Can old cells learn new tricks?Science. 2000;287:1418–1419.
Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow.Nature. 2002;418:41–49.
Savitz SL, Malhotra S, Gupta G, Rosenbaum DM. Cell transplants offer promise for stroke recovery.J Cardiovasc Nurs. 2003;18:57–61.
Perry TE, Kaushal S, Sutherland FW. Thoracic Surgery Directors Association Award: bone marrow as a cell source for tissue engineering heart valves.Ann Thorac Surg. 2003;75:761–767; discussion 767.
Stay of Execution Back-up Documentation page. Americans to Ban Cloning Web site. Available at: http://www.cloninginformation. org/prps/abc-stay_of_execution2.htm. Accessed February 2,2004.
Tateishi-Yuyama E, Matsubara H, Murohara T, et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial.Lancet. 2002;360:427–435.
Conference synopsis: hematopoietic stem cell therapy in autoimmune diseases, October 2001.Biol Blood Marrow Transplant. 2002; 8:407–411.
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Wang, Fs., Trester, C. Bone Marrow Cells and Myocardial Regeneration. Int J Hematol 79, 322–327 (2004). https://doi.org/10.1532/IJH97.03091
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DOI: https://doi.org/10.1532/IJH97.03091