Abstract
Reactive plasmacytosis is a transient expansion of plasma cell progenitors and precursors. This rare condition has been reported to occur mainly in infections and tumors. We describe a case of acute hepatitis A presenting with marked peripheral blood plasmacytosis. Plasma cells made up 27.5% of the mononuclear cells and had the immunophenotype CD10-CD19+CD20-CD21-CD23-CD34-CD38++HLA-DR+. Although the level of interleukin 6 was not increased, the presence of activated T-cells with an inverted CD4/CD8 ratio and high levels of soluble interleukin 2 receptor and neopterin indicated a marked immune response to acute hepatitis A. The patient’s plasma cells had almost disappeared from the blood by hospital day 16. This report may represent the first described case of reactive peripheral blood plasmacytosis in acute hepatitis A.
References
Jego G, Robillard N, Puthier D, et al. Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells.Blood. 1999;94:701–712.
Pellat-Deceunynck C, Jego G, Robillard N, Accard F, Amiot M,Bataille R. Reactive plasmacytoses, a model for studying the biology of human plasma cell progenitors and precursors.Hematol J. 2000;1:362–366.
Koff RS.Hepatitis A.Lancet. 1998;351:1643–1649.
Tone Y, Wada T, Shibata F, et al. Somatic revertant mosaicism in a patient with leukocyte adhesion deficiency type 1.Blood. 2007;109:1182–1184.
Calame KL, Lin KI, Tunyaplin C. Regulatory mechanisms that determine the development and function of plasma cells.Annu Rev Immunol. 2003;21:205–230.
Harada Y, Kawano MM, Huang N, et al. Identification of early plasma cells in peripheral blood and their clinical significance.BrJ Haematol. 1996;92:184–191.
Poje EJ, Soori GS, Weisenburger DD. Systemic polyclonal B-immunoblastic proliferation with marked peripheral blood and bone marrow plasmacytosis.Am J Clin Pathol. 1992;98:222–226.
Shtalrid M, Shvidel L, Vorst E. Polyclonal reactive peripheral blood plasmacytosis mimicking plasma cell leukemia in a patient with staphylococcal sepsis.Leuk Lymphoma. 2003;44:379–380.
Komiya I, Saito Y, Kuriya S. Peripheral blood plasmacytosis in a patient with infectious mononucleosis-like illness.Eur J Haematol. 1991;46:61–62.
Koduri PR, Naides SJ. Transient blood plasmacytosis in par-vovirus B19 infection: a report of two cases.Ann Hematol. 1996;72:49–51.
Gawoski JM, Ooi WW.Dengue fever mimicking plasma cell leukemia.Arch Pathol Lab Med. 2003;127:1026–1027.
Jego G, Bataille R, Pellat-Deceunynck C. Interleukin-6 is a growth factor for nonmalignant human plasmablasts.Blood. 2001;97:1817–1822.
Torre D, Zeroli C, Giola M, et al. Serum levels of interleukin-1 alpha, interleukin-1 beta, interleukin-6, and tumor necrosis factor in patients with acute viral hepatitis.Clin Infect Dis. 1994;18:194–198.
Lauta VM. A review of the cytokine network in multiple myeloma: diagnostic, prognostic, and therapeutic implications.Cancer. 2003;97:2440–2452.
Paul SR, Bennett F, Calvetti JA, et al. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.Proc Natl Acad Sci USA. 1990;87:7512–7516.
Miguel-Garcia A, Orero T, Matutes E, et al. bcl-2 expression in plasma cells from neoplastic gammopathies and reactive plasmacytosis: a comparative study.Haematologica. 1998;83:298–304.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Wada, T., Maeba, H., Ikawa, Y. et al. Reactive Peripheral Blood Plasmacytosis in a Patient with Acute Hepatitis A. Int J Hematol 85, 191–194 (2007). https://doi.org/10.1532/IJH97.06200
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1532/IJH97.06200