Document Type : Original Article

Authors

1 Department of Emergency Medicine, Kerman University of Medical Sciences, Kerman, Iran

2 Department of Biology, Kerman Branch of Islamic Azad University, Kerman, Iran

Abstract

Objective: Most previous retrospective studies failed to show a consistent association between pre-hospital time intervals and mortality in trauma patients, bringing the recommendation of “transport fast to increase survival” under question. The aim of this study was to evaluate the association of response time, scene time, and transport time with 24-hour in-hospital mortality.
Methods: In this cross-sectional study data were collected In the emergency department (ED). Time intervals were obtained from emergency medical service (EMS) central system. All traumatized patients presented to an urban academic hospital by EMS with Emergency Severity Index (ESI) levels 1 or 2 were included in the study. Exclusion criteria were age under 16 or above 65, being transported from outside of the city, severe underlying medical illness, life threatening intoxications, and randomized trauma score (RTS) of more than 10. Patients were followed in the hospital for 24-hour mortality.
Results: A total of 2884 patients were enrolled in the study. Response time, scene time, transport time, and total out of hospital time were all associated with mortality in univariate analysis (P = 0.02, 0.01, <0.001, and 0.001, respectively). In multivariate regression analysis, transport time was associated with 24-hour mortality (P < 0.001, OR [95% CI]: 1.20 [1.16-1.24]).
Conclusion: Although time intervals in most previous studies did not show association with mortality, there is no recommendation such as “pre-hospital time intervals in traumatized patients should not be limited,” since limiting time intervals for taking a traumatized patient to the hospital still seems to be prudent. Our findings support the recommendation of decreasing the transportation and total out of hospital time in the present condition in Kerman city EMS system.
 

Keywords

Main Subjects

1. Hartl R, Gerber LM, Iacono L, Ni Q, Lyons K, Ghajar J. Direct transport within an organized state trauma system reduces mortality in patients with severe traumatic brain injury. J Trauma 2006; 60(6): 1250-6.
2. Nirula R, Maier R, Moore E, Sperry J, Gentillelo L. Scoop and run to the trauma center or stay and play at the local hospital: hospital transfer’s effect on mortality. J Trauma 2010; 69(3): 595-9. doi: 10.1097/TA.0b013e3181ee6e32.
3. Lerner EB, Moscati RM. The golden hour: scientific fact or medical “urban legend”? Acad Emerg Med 2001; 8(7): 758-60.
4. Petri RW, Dyer A, Lumpkin J. The effect of pre-hospital transport time on the mortality from trauma patients. Prehosp Disaster Med 1995; 10(1): 24-9.
5. Pepe PE, Wyatt CH, Bickel WH, Bailey ML, Mattox KL. The relationship between total pre-hospital time and outcome in hypotensive victims of penetrating injuries. Ann Emerg Med 1987; 16(3): 293-7.
6. Feero S, Hedges JR, Simmons E, Irwin L. Does out of hospital EMS time affect trauma survival? Am J Emerg Med 1995; 13(2): 133-5.
7. Carr BG, Caplan JM, Pryor JP, Branas CC. A meta-analysis of pre-hospital care times for trauma. Prehosp Emerg Care 2006; 10(2): 198-206.
8. Sloan EP, Callahan EP, Duda J, Sheaf CM, Robin AP, Barret JA. The effect of urban trauma system hospital bypass on pre-hospital transport times and level 1 trauma patient survival. Ann Emerg Med 1989; 18(11): 1146-50.
9. Ramanujam P, Castillo E, Patel E, Vilke G, Wilson MP, Dunford JV. Prehospital transport time intervals for acute stroke patients. J Emerg Med 2009; 37(1): 40-5. doi: 10.1016/j.jemermed.2007.11.092.
10. Seymour CW, Rea TD, Kahn JM, Walky AJ, Yealy DM, Angus DC. Severe sepsis in pre-hospital emergency care: Analysis of incidence, care, and outcome. Am J Respir Crit Care Med 2012; 186(12): 1264-71. doi: 10.1164/rccm.201204-0713OC.
11. Takahashi M, Kohsaka S, Miyata H, Yoshikawa T, Takagi A, Harada K, et al. Association between prehospital time intervals and shor term outcome in acute heart failure patients. J Card Fail 2011; 17(9): 742-7. doi: 10.1016/j.cardfail.2011.05.005.
12. Gilboy N, Tanabe P, Travers D, Rosenau AM. Emergency Severity Index (ESI): a triage tool for emergency department care, version 4. Implementation handbook 2012 edition. USA: Agency for Healthcare Research and Quality; 2011.
http://www.ahrq.gov/sites/default/files/wysiwyg/professionals/systems/hospital/esi/esihandbk.pdf.
13. Barfod C, Lauritzen MM, Danker JK, Sölétormos G, Forberg JL, Berlac PA, et al. Abnormal vital signs are strong predictors for intensive care unit admission and in-hospital mortality in adults triaged in the emergency department - a prospective cohort study. Scand J Trauma Resusc Emerg Med 2012; 20: 28. doi: 10.1186/1757-7241-20-28.
14. Garbez R, Carrieri-Kohlman V, Stotts N, Chan G, Neighbor M. Factors influencing patients assignment to level 2 and level 3 within the 5 level ESI triage system. J Emerg Nurs 2011; 37(6): 526-32. doi: 10.1016/j.jen.2010.07.010
15. Chawda MN, Hildebrand F, Pape HC, Giannoudis PV. Predicting outcome after multiple trauma: which scoring system? Injury 2004; 35(4): 347-58.
16. Zargar M, Kalantar Motamedi SM, Karbakhsh M, Ghodsi SM, Rahimi-Movaghar V, Panahi F, et al. Trauma care system in Iran. Chin J Traumatol 2011; 14(3): 131-6.
17. Bursac Z, Gauss CH, Williams DK, Hosmer DW. Purposeful selection of variables in logistic regression.
Source Code Biol Med 2008; 3: 17. doi: 10.1186/1751-0473-3-17.
18. De Maio VJ, Stiell IG, Wells GA, Spaite DW. Optimal defibrillation response intervals for maximum out-of-hospital cardiac arrest survival rates. Ann Emerg Med 2003; 42(2): 242-50.
19. Studnek JR, Garvey L, Blackwell T, Vandeventer S, Ward SR. Association between prehospital time intervals and ST elevation myocardial infarction system performance. Circulation 2010; 122(15): 1464-9. doi: 10.1161/CIRCULATIONAHA.109.931154.
20. Spaite DW, Bobrow BJ, Vadeboncoeur TJ, Chikani V, Clark L, Mullins T, et al. The impact of prehospital transport interval on survival in out of hospital cardiac arrest: Implications for regionalization of post-resuscitation care. Resuscitation 2008; 79(1): 61-
6. doi: 10.1016/j.resuscitation.2008.05.006.
21. Gonzalez RP, Cummings GR, Phelan HA, Mulekar MS, Rodning CB. Does increased emergency medical services prehospital time affect patient mortality in rural motor vehicle crashes? A statewide analysis. Am J Surg 2009; 197(1): 30-4. doi: 10.1016/j.
amjsurg.2007.11.018.
22. Newgard CD, Schmicker RH, Hedges JR, Tricket JP, Davis DP, Bulger EM, et al. Emergency medical services and intervals in trauma: assessment of a “golden hour” in a north American prospective cohort. Ann Emerg Med 2010; 55(3): 235-46. doi:
10.1016/j.annemergmed.2009.07.024.