Abstract
The use of various NMR techniques allows to demonstrate the aggregation processes of β-glycyrrhizic acid (GA) in water/methanol (4:1, v:v) mixture with solution pH≤5. The micelle formation was monitored by measuring T2 relaxation and diffusion of GA. The model of gelation from micelles was suggested. It was shown that NMR chemical shifts of the protons of GA glucuronic moiety are sensitive to solution pH and not sensitive to GA concentration changes. At the same time the protons of triterpene moiety are sensitive to the nearest environment during the GA aggregation, and micelles are formed by hydrophobic interaction between the triterpene moieties of GA.
Dedicated to: Kev Salikhov on the occasion of his 80th birthday.
Acknowledgements
This publication is supported by grant 15-04-02538 from the Russian Foundation for Basic Research.
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