Abstract
A new phenolic sesquiterpene, dysoxyphenol (1), and the known sesquiterpene, 7R,10S-2-hydroxycalamenene (2), were isolated from the acetone extract of Dysoxylum densiflorum seeds. The structures of these compounds were determined based on physical, Nuclear Magnetic Resonance, and mass spectral data. Both compounds were evaluated for their antibacterial and antifungal properties against seven pathogenic bacteria and two wood-rotting fungi, respectively. The results showed that both compounds have significant antibacterial properties only against Bacillus subtilis (Minimum Inhibitory Concentration 28 μM), while in the antifungal evaluation compound 1 was found to be more active than compound 2. Therefore, compound 1 has promising antifungal properties that can be developed further for finding new antifungal agents.
Acknowledgements
The authors are grateful for the financial support from the Grant of Riset KK A, Institut Teknologi Bandung, 2018. They thank the Herbarium Bogoriense, Bogor, Indonesia, for identification of the plant specimen.
Conflict of interest statement: The authors declare no conflict of interest relating to the article.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/znc-2019-0072).
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