A new polyketide, TMC-151 A monoacetate (1), along with a known analogue, TMC-151 F (2), was isolated from ethyl acetate extracts of the fermentation broth of Bionectria ochroleuca isolated in Taiwan. Their structures were elucidated on the basis of spectroscopic analysis. The antiproliferative activities of 1 and 2 were evaluated against MT-2 (human leukemia), A498 (human renal carcinoma), NPC-tw01 (human nasopharyngeal carcinoma), H-226 and A549 (non-small cell lung cancer) cell lines, and their IC50 values ranged from 18.3 to 40.2 μM.
Received: 2006-5-22
Published Online: 2014-6-2
Published in Print: 2007-4-1
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