Abstract
Catharanthus roseus cell suspension cultures were employed for the biotransformation of (-)-caryophyllene oxide (1), and four metabolites, 15-hydroxycaryophyllene oxide (2), 4β ,5α- dihydroxycaryophyll-8(13)-ene (3), 2β -hydroxycaryophyllene oxide (4), and 2-hydroxy-4,5- epoxycaryophyllan-13-ol (5) were obtained. Metabolites 4 and 5 were found to be new compounds, and their structures were deduced by different spectroscopic techniques.
Keywords : (-)-Caryophyllene Oxide; Biotransformation; Catharanthus roseus; Cell Suspension Cultures
Received: 2005-8-8
Published Online: 2014-6-2
Published in Print: 2006-2-1
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