Abstract
Prevalence studies suggest that Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) are the most common dementing illnesses in the elderly. The aim of this narrative review was to provide data on sleep-related behaviors in AD and DLB. This paper contains arguments, with a clinical approach, on both circadian rhythm changes and dissociated states of wakefulness and sleep in these two conditions.
About the authors
Alberto Raggi studied Medicine at the University of Bologna. He served his residency in Psychiatry at the University of Modena and in Neurology at the University of Florence and is board certified in both specialties. He has worked as a staff neurologist for some public hospitals (Borgomanero, Faenza, Piacenza), the Neurology and Neurorehabilitation Unit of the San Raffaele Turro Hospital in Milan and the Department of Neurology of the Oasi Institute for Research on Mental Retardation and Brain Aging in Troina. He works at the Neurology Unit of the Morgagni–Pierantoni public Hospital of Forlì since 2012. His main research focus is in behavioural neurology. He has authored publications in both international and national scientific journals. He has served as occasional reviewer for several neuroscience journals.
Walter Neri received his MD at the University of Bologna in 1977 where he also received the specialization in Neurology in 1981. He has practiced Neurology at the Morgagni-Pierantoni public hospital of Forlì to date. He has been Chief of the Neurophysiology Laboratory for many years and he is the Director of the Unit of Neurology since 2000. Dr. Neri is involved in both clinical neurology and neurophysiology, with a large spectrum of interests including neuroimmunology, peripheral neuropathy, neurodegenerative and cerebrovascular disorders. He is the author of publications in both international and national scientific journals.
Raffaele Ferri has been involved in the scientific study of the neurophysiological aspects of Alzheimer’s disease and other dementias and is the Head of a clinical unit specifically devoted to the diagnosis and treatment of these conditions. His specific areas of interest cover also the description, analysis and understanding of various aspects of human sleep and sleep disorders such restless legs syndrome, narcolepsy, and REM sleep behavior disorder. He has published over 300 papers in international peer-reviewed scientific journals, in addition to book chapters. Currently Scientific Secretary of the European Restless Legs Syndrome Study Group and member-at-large of the International Restless Legs Syndrome Study Group, Dr. Ferri is also Associate Editor for the journal Sleep, Action Editor for the International Journal of Psychophysiology, Academic Editor for PlosONE, and is member of the editorial board of Clinical Neurophysiology, Sleep Medicine, and Sleep Medicine Reviews.
Acknowledgments
This work was partially supported by the Italian Ministry of Health (‘Ricerca Corrente’).
Conflict of interest statement: None.
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