Abstract
The advancement of research in colloidal systems has led to the increased application of this technology in more effective and targeted drug delivery. Nanotechnology enables control over functionality parameters and allows innovations in biodegradable, biocompatible, and stimuli-responsive delivery systems. The first closed bilayer phospholipid system, the liposome system, has been making steady progress over five decades of extensive research and has been efficient in achieving many desirable parameters such as remote drug loading, size-controlling measures, longer circulation half-lives, and triggered release. Liposome-mediated drug delivery has been successful in overcoming obstacles to cellular and tissue uptake of drugs with improved biodistribution in vitro and in vivo. These colloidal nanovehicles have moved on from a mere concept to clinical applications in various drug delivery systems for antifungal, antibiotic, and anticancer drugs.
About the authors
Sumaira Naeem received her master’s degree from University of the Punjab, Lahore, Pakistan in 2007. She is a lecturer in chemistry at the University of Gujrat, Gujrat, Pakistan. She joined the Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia as a doctoral candidate in 2013 after getting study leave from the University of Gujrat. Her research interests include development and in vitro evaluation of targetable anticancer phospholipid drug carriers, red blood cell mimicking using phospholipid liposomes, and its applications in drug delivery.
Geetha Viswanathan received her doctorate in cell and molecular biology from the Centre for Cellular and Molecular Biology, Hyderabad (degree awarded from the Jawaharlal Nehru University) India. She then joined the pharmaceutical industry as a research scientist and was later awarded a post-doctoral fellowship at the Indian Institute of Technology, Madras, India. She is currently a post-doctoral fellow at the Department of Pharmacy, University of Malaya. Her research interests include various aspects of cancer cell biology signaling and anticancer therapeutics, drug delivery using various nanocarriers, and characterization.
Misni Bin Misran received his doctorate in chemistry from East Anglia University, UK. Currently, he is a professor at the Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia. His research interests include colloids, surfactants, emulsions, microemulsions, liposomes, aerosols, nanoparticles, and sole gels. He is also active in commercialization and innovation, consultancy projects, and is currently supervising many PhD candidates. He is also a member of a number of professional and learned societies.
Acknowledgments
The authors would like to acknowledge and express their sincere gratitude to the Ministry of Education, Malaysia, for the High Impact Research (Grant No. UM-MOHE: UM.C/625/1/HIR/MOHE//SC/09), University of Malaya Research Grant (FL001F- 13 BIO) and (RP022C-16SUS), Fundamental Grant Research Scheme (FP013-2015A), Post Graduate Research Fund (PG094-2014A) and Post Graduate Research Fund (PG123- 2012B). The authors would also like to acknowledge University of Gujrat, Pakistan. The authors are also grateful and acknowledge University of Malaya Bright Sparks Unit for supporting this work.
Conflict of interest statement: The authors declare that they have no conflict of interest regarding the publication of this study.
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