Abstract
Background:
Uterine artery Doppler pulsatility index (UtA-PI) may be different in pregnancies with egg donation (ICSI-ED) as compared to conceptions with autologous intra-cytoplasmatic sperm injection (autologous ICSI) and to spontaneous conceptions (SC).
Methods:
One hundred and ninety-four pregnant women with different modes of conception (MC) were prospectively evaluated: 53 ICSI-ED, 36 autologous ICSI and 105 SC. To evaluate the effects of different MC on PI, multivariable linear regression (MLR) models predicting UtA-PI were fitted after adjustment for maternal age, body mass index, race, parity, smoking status and gestational age.
Results:
In the first trimester, at MLR, autologous ICSI was not associated with a significantly different UtA-PI [estimate (EST) 0.01; 95% confidence interval (CI) −0.19, 0.2; P=0.9] when compared to SC. Conversely, MC by ICSI-ED was associated with lower first trimester UtA-PI (EST −0.32; CI −0.55, −0.08; P=0.01) when compared to SC. At MLR, MC by autologous ICSI and by ICSI-ED were not associated with significant differences in the second and third trimester UtA-PI when compared to SC.
Conclusion:
ICSI-ED conception presented lower UtA-PI when compared to SC at 11+0–13+6 weeks but not at later assessments. Correction of UtA-PI measurement specifying the origin of oocyte may be useful in first trimester screening.
Acknowledgments
We acknowledge physicians, biologists and midwifes in Prenatal Diagnosis and Infertility Units of San Raffaele Hospital for their voluntary cooperation, which made possible this non-funded research.
Author’s statement
Conflict of interest: Authors state no conflict of interest.
Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.
Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.
References
[1] Pijnenborg R, Vercruysse L, Hanssens M. The uterine spiral arteries in human pregnancy: facts and controversies. Placenta. 2006;27:939–58.10.1016/j.placenta.2005.12.006Search in Google Scholar PubMed
[2] Hypertension in pregnancy. Obstet Gynecol. 2013;122: 1122–31.10.1097/01.AOG.0000437382.03963.88Search in Google Scholar PubMed
[3] McDonald SD, Han Z, Mulla S, Murphy KE, Beyene J, Ohlsson A. Preterm birth and low birth weight among in vitro fertilization singletons: a systematic review and meta-analyses. Eur J Obstet Gynecol Reprod Biol. 2009;146:138–48.10.1016/j.ejogrb.2009.05.035Search in Google Scholar PubMed
[4] van der Hoorn MLP, Lashley EELO, Bianchi DW, Claas FHJ, Schonkeren CMC, Scherjon SA. Clinical and immunologic aspects of egg donation pregnancies: a systematic review. Hum Reprod Update. 2010;16:704–12.10.1093/humupd/dmq017Search in Google Scholar PubMed
[5] Akolekar R, Syngelaki A, Sarquis R, Zvanca M, Nicolaides KH. Prediction of early, intermediate and late pre-eclampsia from maternal factors, biophysical and biochemical markers at 11–13 weeks. Prenat Diagn. 2011;31:66–74.10.1002/pd.2660Search in Google Scholar PubMed
[6] Cetin I, Huppertz B, Burton G, Cuckle H, Gonen R, Lapaire O, et al. Pregenesys pre-eclampsia markers consensus meeting: what do we require from markers, risk assessment and model systems to tailor preventive strategies? Placenta. 2011;32:S4–16.10.1016/j.placenta.2010.11.022Search in Google Scholar PubMed
[7] Bujold E, Roberge S, Lacasse Y, Bureau M, Audibert F, Marcoux S, et al. Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy. Obstet Gynecol. 2010;116:402–14.10.1097/AOG.0b013e3181e9322aSearch in Google Scholar PubMed
[8] Roberge S, Villa P, Nicolaides K, Giguère Y, Vainio M, Bakthi A, et al. Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysis. Fetal Diagn Ther. 2012;31:141–6.10.1097/01.ogx.0000421448.89490.b7Search in Google Scholar
[9] O’Gorman N, Wright D, Rolnik DL, Nicolaides KH, Poon LC. Study protocol for the randomised controlled trial: combined multimarker screening and randomised patient treatment with ASpirin for evidence based PREeclampsia prevention (ASPRE). BMJ Open 2016;6:e011801.10.1136/bmjopen-2016-011801Search in Google Scholar PubMed PubMed Central
[10] Prefumo F, Fratelli N, Soares SC, Thilaganathan B. Uterine artery Doppler velocimetry at 11–14 weeks in singleton pregnancies conceived by assisted reproductive technology. Ultrasound Obstet Gynecol. 2007;29:141–5.10.1002/uog.3842Search in Google Scholar PubMed
[11] Carbone IF, Cruz JJ, Sarquis R, Akolekar R, Nicolaides KH. Assisted conception and placental perfusion assessed by uterine artery Doppler at 11-13 weeks’ gestation. Hum Reprod. 2011;26:1659–64.10.1093/humrep/der117Search in Google Scholar PubMed
[12] Tayyar A, Guerra L, Wright A, Wright D, Nicolaides KH. Uterine artery pulsatility index in the three trimesters of pregnancy: effects of maternal characteristics and medical history. Ultrasound Obstet Gynecol. 2015;45:689–97.10.1002/uog.14789Search in Google Scholar PubMed
[13] Pilalis A, Souka AP, Antsaklis P, Basayiannis K, Benardis P, Haidopoulos D, et al. Screening for pre-eclampsia and small for gestational age fetuses at the 11–14 weeks scan by uterine artery Dopplers. Acta Obstet Gynecol Scand. 2007;86:530–4.10.1080/00016340601155056Search in Google Scholar PubMed
[14] Plasencia W, Maiz N, Poon L, Yu C, Nicolaides KH. Uterine artery Doppler at 11+0 to 13+6 weeks and 21+0 to 24+6 weeks in the prediction of pre-eclampsia. Ultrasound Obstet Gynecol. 2008;32:138–46.10.1002/uog.5402Search in Google Scholar PubMed
[15] Pilalis A, Souka AP, Antsaklis P, Daskalakis G, Papantoniou N, Mesogitis S, et al. Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11–14 weeks’ gestation. Ultrasound Obstet Gynecol. 2007;29:135–140.10.1002/uog.3881Search in Google Scholar PubMed
[16] Gómez O, Figueras F, Fernández S, Bennasar M, Martínez JM, Puerto B, et al. Reference ranges for uterine artery mean pulsatility index at 11–41 weeks of gestation. Ultrasound Obstet Gynecol. 2008;32:128–32.10.1002/uog.5315Search in Google Scholar PubMed
[17] R Core Team: R: A language and environment for statistical computing [Internet]. Available from: http://www.R-project.org/.Search in Google Scholar
[18] Rizzo G, Aiello E, Pietrolucci ME, Arduini D. Placental volume and uterine artery Doppler evaluation at 11+0 to 13+6 weeks of gestation in pregnancies conceived with in vitro fertilization: comparison between autologous and donor oocyte recipients. Ultrasound Obstet Gynecol. 2015;47:726–31.10.1002/uog.14918Search in Google Scholar PubMed
[19] Klatsky PC, Delaney SS, Caughey AB, Tran ND, Schattman GL, Rosenwaks Z. The role of embryonic origin in preeclampsia. Obstet Gynecol. 2010;116:1387–92.10.1097/AOG.0b013e3181fb8e59Search in Google Scholar PubMed
[20] Bonagura TW, Babischkin JS, Aberdeen GW, Pepe GJ, Albrecht ED. Prematurely elevating estradiol in early baboon pregnancy suppresses uterine artery remodeling and expression of extravillous placental vascular endothelial growth factor and α1β1 and α5β1 integrins. Endocrinology. 2012;153:2897–906.10.1210/en.2012-1141Search in Google Scholar PubMed PubMed Central
[21] Thilaganathan B. Association of higher maternal blood pressure with lower infant birthweight. Hypertension. 2016;67:499–500.10.1161/HYPERTENSIONAHA.115.06880Search in Google Scholar PubMed
[22] Cavoretto P, Dallagiovanna C, Vigano P, Somigliana E, Persico N, Papaleo E, et al. First trimester combined screening test in pregnancies derived from blastocyst transfer. Eur J Obstet Gynecol. 2016;198:50–5.10.1016/j.ejogrb.2015.12.026Search in Google Scholar PubMed
[23] Savasi VM, Mandia L, Laoreti A, Ghisoni L, Duca P, Cetin I. First trimester placental markers in oocyte donation pregnancies. Placenta. 2015;36:921–5.10.1016/j.placenta.2015.06.009Search in Google Scholar PubMed
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